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The map label for this gene is btuE [H]

Identifier: 169627795

GI number: 169627795

Start: 696619

End: 697107

Strand: Direct

Name: btuE [H]

Synonym: MAB_0693

Alternate gene names: 169627795

Gene position: 696619-697107 (Clockwise)

Preceding gene: 169627793

Following gene: 169627796

Centisome position: 13.75

GC content: 62.37

Gene sequence:

>489_bases
ATGACCGATCTCGCGTCCATCCCGTTGACCGCCCTGGACGGCTCGGCGCTGTCACTTGCCGATTTCGGCGATAACGCCGT
CCTGGTGGTCAACGTCGCGTCCAAGTGCGGTCTCACCCCGCAGTACGCGGCTCTGGAGAAGCTGGCCTCCGACTACGCCG
ACCGTGGTCTGACCGTGCTCGGAGTTCCCTGTAACCAATTCATGGGGCAGGAACCGGGCACGGCGGAGGAAATTCGGGAG
TTCTGCTCGTCCACCTATGGGGTGAGTTTCCCGCTGCTGGAGAAGGCCGATGTGAACGGTGACAATCGGCATCCGCTGTA
CGCGGAGCTCATCAAGACCGCCGATGCGGAGGGTACCGCGGGTGATGTGCAGTGGAACTTCGAGAAATTCTTGATCGCGC
GGGATGGTTCGGTGGTCAATAGATTCCGGCCGACAACAGTGCCGGACGCGCCCGAGGTGATCGCGGCCATCGAGAAGGAG
CTGGGCTAG

Upstream 100 bases:

>100_bases
GGCCCGAGGAGAATTCGTCCTCCTCGCTCATACATGACCTCCCGCAACTTTGCTTGGTGTGCAAACAGTCAACCATCGCA
GCCCCGGTACCGTGGGAGGC

Downstream 100 bases:

>100_bases
CGCCCGGAGCGTTCTTTTCGATGCGGGGTGTCTGACACCTTGCGTACATCTGACGTTGCCACACTAGCGGCATGGCAGGA
CAGCTGCTGGTATCGGTGTC

Product: glutathione peroxidase

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MTDLASIPLTALDGSALSLADFGDNAVLVVNVASKCGLTPQYAALEKLASDYADRGLTVLGVPCNQFMGQEPGTAEEIRE
FCSSTYGVSFPLLEKADVNGDNRHPLYAELIKTADAEGTAGDVQWNFEKFLIARDGSVVNRFRPTTVPDAPEVIAAIEKE
LG

Sequences:

>Translated_162_residues
MTDLASIPLTALDGSALSLADFGDNAVLVVNVASKCGLTPQYAALEKLASDYADRGLTVLGVPCNQFMGQEPGTAEEIRE
FCSSTYGVSFPLLEKADVNGDNRHPLYAELIKTADAEGTAGDVQWNFEKFLIARDGSVVNRFRPTTVPDAPEVIAAIEKE
LG
>Mature_161_residues
TDLASIPLTALDGSALSLADFGDNAVLVVNVASKCGLTPQYAALEKLASDYADRGLTVLGVPCNQFMGQEPGTAEEIREF
CSSTYGVSFPLLEKADVNGDNRHPLYAELIKTADAEGTAGDVQWNFEKFLIARDGSVVNRFRPTTVPDAPEVIAAIEKEL
G

Specific function: Not essential for B12 transport; however, it is an auxiliary component of the transport system [H]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=160, Percent_Identity=39.375, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI75709200, Length=152, Percent_Identity=40.7894736842105, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI90903240, Length=152, Percent_Identity=40.7894736842105, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI90903238, Length=121, Percent_Identity=41.3223140495868, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI192455698, Length=133, Percent_Identity=34.5864661654135, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4557629, Length=164, Percent_Identity=35.3658536585366, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI6006001, Length=156, Percent_Identity=37.1794871794872, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI33186887, Length=151, Percent_Identity=37.0860927152318, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI41406084, Length=172, Percent_Identity=33.7209302325581, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI32967607, Length=167, Percent_Identity=34.7305389221557, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1788003, Length=166, Percent_Identity=47.5903614457831, Blast_Score=169, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17506887, Length=153, Percent_Identity=38.562091503268, Blast_Score=119, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17535473, Length=164, Percent_Identity=37.8048780487805, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71993584, Length=148, Percent_Identity=37.8378378378378, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17550320, Length=176, Percent_Identity=35.2272727272727, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193209493, Length=174, Percent_Identity=34.4827586206897, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI193210707, Length=145, Percent_Identity=40.6896551724138, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319721, Length=138, Percent_Identity=48.5507246376812, Blast_Score=142, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322228, Length=162, Percent_Identity=41.9753086419753, Blast_Score=142, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322826, Length=148, Percent_Identity=38.5135135135135, Blast_Score=124, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24656772, Length=151, Percent_Identity=41.7218543046358, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24656767, Length=151, Percent_Identity=41.7218543046358, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24656777, Length=151, Percent_Identity=41.7218543046358, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI85726443, Length=147, Percent_Identity=36.0544217687075, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: NA

Molecular weight: Translated: 17268; Mature: 17136

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLASIPLTALDGSALSLADFGDNAVLVVNVASKCGLTPQYAALEKLASDYADRGLTVL
CCCCCCCCEEECCCCEEEEEECCCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHCCCEEE
GVPCNQFMGQEPGTAEEIREFCSSTYGVSFPLLEKADVNGDNRHPLYAELIKTADAEGTA
ECCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
GDVQWNFEKFLIARDGSVVNRFRPTTVPDAPEVIAAIEKELG
CCEEECCEEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TDLASIPLTALDGSALSLADFGDNAVLVVNVASKCGLTPQYAALEKLASDYADRGLTVL
CCCCCCCEEECCCCEEEEEECCCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHCCCEEE
GVPCNQFMGQEPGTAEEIREFCSSTYGVSFPLLEKADVNGDNRHPLYAELIKTADAEGTA
ECCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
GDVQWNFEKFLIARDGSVVNRFRPTTVPDAPEVIAAIEKELG
CCEEECCEEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3528129; 9097039; 9278503 [H]