Click here to switch to the map view.

The map label for this gene is purC

Identifier: 169627791

GI number: 169627791

Start: 691317

End: 692210

Strand: Direct

Name: purC

Synonym: MAB_0689

Alternate gene names: 169627791

Gene position: 691317-692210 (Clockwise)

Preceding gene: 169627789

Following gene: 169627792

Centisome position: 13.64

GC content: 61.86

Gene sequence:

>894_bases
ATGCGTCCTTCGCTGTCCGATTACCAGCATGTGGCCAGCGGCAAGGTCCGTGAGCTGTATCGCGTCGACGACGAACACCT
GCTGTTCGTTGCCACCGACCGGATTTCCGCATTCGATTTCGTCCTGGATACCCCGATACCCGATAAGGGACGCATCCTCA
CCGCGATGAGCGTGTTCTTCTTCGGACTGCTGACCGTGCCGAACCATCTGGCCGGTCCGCCCGACGATCCGCGCATTCCC
GAGGAAGTGTTGGGCCGGGCATTACTGGTGCGCCGCCTCGACATGCTTCCCGTGGAATGTGTGGCACGCGGTTATCTCAC
GGGGTCCGGGCTGCTGGATTATCAGCGCACCGGTGCGGTGTGTGGACATGTGTTGCCGCAGGGACTGGGGGAAGCCAGCC
GCCTGGACCCACCGTTGTTCACCCCGGCGACCAAAGCCGACATCGGCGAGCACGATATGAATGTCGACTTCGCCGCTGTG
GTCGGTCTGGTCGGCGCTGTGCGTGCCAACCAGCTGCGTGACGAGACCATCAAGATCTACACGCGCGCCGCGGCGCACGC
CTTGCACAAGGGAATCATCCTGGCCGACACCAAATTCGAATTCGGCGTCGATATCGAGGGCAATTTGGTGCTTGCCGACG
AAGTGTTCACGCCTGACTCGTCCCGGTACTGGGATGCCGCCCACTATCAGCCCGGGGTGGTTCAGGACAGCTTCGACAAG
CAGTTCGTCCGCAATTGGCTTACCGGCCCCGAATCGGGATGGGATCGTGCGTCGGATACTCCGCCGCCGCCGTTGCCAGA
TGAGGTGGCAGTGGCCACGCGGGAACGTTATATCGAGGCCTATGAGCGCATTTCAGGGCTGAGCTTCTCTGATTGGATTG
GCCCGTCGGCGTGA

Upstream 100 bases:

>100_bases
TGGTCCAGGTCGCGACCGCTATATCGCTGAACAGCTGGGCGAGCAACCGTCCCGGTCGGGTCGAGTAGGGCAGGAATCGC
ATGAATCGTAGGATGGCACG

Downstream 100 bases:

>100_bases
GCGGGCCGGTACGCCCGCCCGTCGCGAACCGTATCGACACTCTCCGCGAGTATCACGGGGACACCTTCGTCGATCCGTAT
GAATGGATGCGTGAAAAGGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRPSLSDYQHVASGKVRELYRVDDEHLLFVATDRISAFDFVLDTPIPDKGRILTAMSVFFFGLLTVPNHLAGPPDDPRIP
EEVLGRALLVRRLDMLPVECVARGYLTGSGLLDYQRTGAVCGHVLPQGLGEASRLDPPLFTPATKADIGEHDMNVDFAAV
VGLVGAVRANQLRDETIKIYTRAAAHALHKGIILADTKFEFGVDIEGNLVLADEVFTPDSSRYWDAAHYQPGVVQDSFDK
QFVRNWLTGPESGWDRASDTPPPPLPDEVAVATRERYIEAYERISGLSFSDWIGPSA

Sequences:

>Translated_297_residues
MRPSLSDYQHVASGKVRELYRVDDEHLLFVATDRISAFDFVLDTPIPDKGRILTAMSVFFFGLLTVPNHLAGPPDDPRIP
EEVLGRALLVRRLDMLPVECVARGYLTGSGLLDYQRTGAVCGHVLPQGLGEASRLDPPLFTPATKADIGEHDMNVDFAAV
VGLVGAVRANQLRDETIKIYTRAAAHALHKGIILADTKFEFGVDIEGNLVLADEVFTPDSSRYWDAAHYQPGVVQDSFDK
QFVRNWLTGPESGWDRASDTPPPPLPDEVAVATRERYIEAYERISGLSFSDWIGPSA
>Mature_297_residues
MRPSLSDYQHVASGKVRELYRVDDEHLLFVATDRISAFDFVLDTPIPDKGRILTAMSVFFFGLLTVPNHLAGPPDDPRIP
EEVLGRALLVRRLDMLPVECVARGYLTGSGLLDYQRTGAVCGHVLPQGLGEASRLDPPLFTPATKADIGEHDMNVDFAAV
VGLVGAVRANQLRDETIKIYTRAAAHALHKGIILADTKFEFGVDIEGNLVLADEVFTPDSSRYWDAAHYQPGVVQDSFDK
QFVRNWLTGPESGWDRASDTPPPPLPDEVAVATRERYIEAYERISGLSFSDWIGPSA

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Escherichia coli, GI1788820, Length=239, Percent_Identity=29.2887029288703, Blast_Score=68, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319326, Length=296, Percent_Identity=42.9054054054054, Blast_Score=246, Evalue=4e-66,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_MYCA9 (B1MHW4)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001701440.1
- ProteinModelPortal:   B1MHW4
- SMR:   B1MHW4
- EnsemblBacteria:   EBMYCT00000005503
- GeneID:   5963224
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_0689
- GeneTree:   EBGT00050000017539
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- BioCyc:   MABS561007:MAB_0689-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 32730; Mature: 32730

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPSLSDYQHVASGKVRELYRVDDEHLLFVATDRISAFDFVLDTPIPDKGRILTAMSVFF
CCCCHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHEECCCCCCCCHHHHHHHHHH
FGLLTVPNHLAGPPDDPRIPEEVLGRALLVRRLDMLPVECVARGYLTGSGLLDYQRTGAV
HHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHH
CGHVLPQGLGEASRLDPPLFTPATKADIGEHDMNVDFAAVVGLVGAVRANQLRDETIKIY
HHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TRAAAHALHKGIILADTKFEFGVDIEGNLVLADEVFTPDSSRYWDAAHYQPGVVQDSFDK
HHHHHHHHHCCEEEEECCEEECCCCCCCEEEECCEECCCCCCCCCCCCCCCCCCCCHHHH
QFVRNWLTGPESGWDRASDTPPPPLPDEVAVATRERYIEAYERISGLSFSDWIGPSA
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC
>Mature Secondary Structure
MRPSLSDYQHVASGKVRELYRVDDEHLLFVATDRISAFDFVLDTPIPDKGRILTAMSVFF
CCCCHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHEECCCCCCCCHHHHHHHHHH
FGLLTVPNHLAGPPDDPRIPEEVLGRALLVRRLDMLPVECVARGYLTGSGLLDYQRTGAV
HHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHH
CGHVLPQGLGEASRLDPPLFTPATKADIGEHDMNVDFAAVVGLVGAVRANQLRDETIKIY
HHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TRAAAHALHKGIILADTKFEFGVDIEGNLVLADEVFTPDSSRYWDAAHYQPGVVQDSFDK
HHHHHHHHHCCEEEEECCEEECCCCCCCEEEECCEECCCCCCCCCCCCCCCCCCCCHHHH
QFVRNWLTGPESGWDRASDTPPPPLPDEVAVATRERYIEAYERISGLSFSDWIGPSA
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA