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The map label for this gene is mrpD [H]

Identifier: 169627737

GI number: 169627737

Start: 633222

End: 634823

Strand: Reverse

Name: mrpD [H]

Synonym: MAB_0634c

Alternate gene names: 169627737

Gene position: 634823-633222 (Counterclockwise)

Preceding gene: 169627738

Following gene: 169627736

Centisome position: 12.53

GC content: 64.42

Gene sequence:

>1602_bases
ATGAGCACCATGTCTGTTCTGACGCCGCTGCCCGTCCTGGTGCCGACCACCGCCGCGGCACTAACCCTCATCGCCGGCAG
ACGCCCCCGGTTGCAGCTGTTGATCACGGTCACCGCGTTGACCACGGTGCTCGGAGTCTGTACCGCGTTGCTATACCTCA
CGGACCGCGACGGCACCTTCGCCCTAGCCGTCGGCGGCTGGGGGCCCACCGAAGAGAAGCTGGGGCCACTCGGAATAACC
CTTGTGGTGGATCGCCTTTCGGCGCTGATGCTGGTGGTTTCGGCCATCGTGCTGCTGGCGGTGGTGCTGTACGCGGCCGC
TCAGGGTATCCGTGACGGCGACGAACGACAGCCGGTGTCGATCTTCATGCCCACCTACCTGGCGCTGTCGGCCGGAGTGT
GCAACGCCTTCCTCGCTGGCGATCTGTTCAACCTCTATGTCGGATTCGAGGTACTACTGGCCGCGAGCTTCGTGCTGTTG
ACCATCGGTGCCAGCGCCGACAGGGTGCGTGCGGGCATCTCGTATGTGATGGTCTCGATGATGTCCTCGGTGGTCTTCCT
GCTGGGCATCGCCTTCGTATATGCGGCGACCGGGACCCTGAATATGGCCGAAATCGCGCTCCGCGCAGACGGTATCCCAT
CGGGTACCCGAATGGCGATCTTCGCGGTGCTGCTGGTGGGCTTCGCCATCAAGGCTGCCGTGTTCCCGTTGTCCACCTGG
CTGCCCGACTCCTACCCCACCGCACCGGCACCGGTGACCGCGGTCTTCGCGGGGTTGCTCACCAAGGTGGGCGTATACGC
CATTATTCGCGCGCATTCCCTGCTGTTCCCCGGCGGCGGGCTCAACACCGTGCTGCTGGTGGCGGCGCTGCTCACCATGA
TCGTCGGCATCCTGGGTGCCATCGCGCAAAGTGATATCAAGCGATTGCTGTCCTTCACCCTGGTCAGCCACATCGGGTAC
ATGATCTTCGGCATCGCGCTGTCCAATGAACTTGGCATGTCGGGTGCCATTTACTACGTGGCACACCACATCATCGTGCA
AACCACCTTGTTCCTCGTGGTAGGCCTCATCGAACGCCAGGCGGGGGCATCGTCCCTGAATCGTCTGGGTGGACTCGCCG
CCGCGAGCCCGCTGCTTGCCTTCGTGTTCGTGGTTCCCGCCCTGAATCTGGGCGGCATTCCGCCGTTCTCGGGATTCATC
GGCAAGGTTGCGCTGTTAGAGGCCGGATCATTGCAGGGCTCGGTGCTGGCCTGGGCCCTCGTCGCCGGCGGCACTATCAC
CAGCCTGCTGACTCTGTACGCCGTGGCCCGAGTATGGACAAAGGCGTTCTGGCGCCCGCGATCCGACGCCCCGGAGGGAG
ATCTGGCCGCAGCCGCGCCCACAGCACTTCTCGACGATGCCGAGGATGTCGCGTTTGTGGATCGCGCAGATGTGGGCAGA
ATTCCGGCCGGCATGCTGGCCCCTACGCTGGGACTGATCGCGGTGGGGGTGGCGCTGACGATCTTCGCCGGGCCCATCAT
CGCGATCAGCGATCGCGCCGCGGCCGAGGTCCGTGATCGCACGGTATACATCAGCGCTGTCCTCGGGGGTGCACCGCGAT
GA

Upstream 100 bases:

>100_bases
AGCCGGTCACCGACGGCAAGGACGAACATCGGGACGTATCCGAGTCGCTCGACGAAGACTCACCCGCTGAACTCGACGCA
TTGCCCACGGGTGAGAAGTC

Downstream 100 bases:

>100_bases
AGCGACTGGCGCGGTACGGGCCACGTGAAATCGTGCTGCGTGCCTGGACATTGGTGTGGCTCATGCTGGTGTGGACGATG
CTCTGGGGCAACTTCTCGGT

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MSTMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLGVCTALLYLTDRDGTFALAVGGWGPTEEKLGPLGIT
LVVDRLSALMLVVSAIVLLAVVLYAAAQGIRDGDERQPVSIFMPTYLALSAGVCNAFLAGDLFNLYVGFEVLLAASFVLL
TIGASADRVRAGISYVMVSMMSSVVFLLGIAFVYAATGTLNMAEIALRADGIPSGTRMAIFAVLLVGFAIKAAVFPLSTW
LPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLNTVLLVAALLTMIVGILGAIAQSDIKRLLSFTLVSHIGY
MIFGIALSNELGMSGAIYYVAHHIIVQTTLFLVVGLIERQAGASSLNRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFI
GKVALLEAGSLQGSVLAWALVAGGTITSLLTLYAVARVWTKAFWRPRSDAPEGDLAAAAPTALLDDAEDVAFVDRADVGR
IPAGMLAPTLGLIAVGVALTIFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR

Sequences:

>Translated_533_residues
MSTMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLGVCTALLYLTDRDGTFALAVGGWGPTEEKLGPLGIT
LVVDRLSALMLVVSAIVLLAVVLYAAAQGIRDGDERQPVSIFMPTYLALSAGVCNAFLAGDLFNLYVGFEVLLAASFVLL
TIGASADRVRAGISYVMVSMMSSVVFLLGIAFVYAATGTLNMAEIALRADGIPSGTRMAIFAVLLVGFAIKAAVFPLSTW
LPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLNTVLLVAALLTMIVGILGAIAQSDIKRLLSFTLVSHIGY
MIFGIALSNELGMSGAIYYVAHHIIVQTTLFLVVGLIERQAGASSLNRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFI
GKVALLEAGSLQGSVLAWALVAGGTITSLLTLYAVARVWTKAFWRPRSDAPEGDLAAAAPTALLDDAEDVAFVDRADVGR
IPAGMLAPTLGLIAVGVALTIFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR
>Mature_532_residues
STMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLGVCTALLYLTDRDGTFALAVGGWGPTEEKLGPLGITL
VVDRLSALMLVVSAIVLLAVVLYAAAQGIRDGDERQPVSIFMPTYLALSAGVCNAFLAGDLFNLYVGFEVLLAASFVLLT
IGASADRVRAGISYVMVSMMSSVVFLLGIAFVYAATGTLNMAEIALRADGIPSGTRMAIFAVLLVGFAIKAAVFPLSTWL
PDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLNTVLLVAALLTMIVGILGAIAQSDIKRLLSFTLVSHIGYM
IFGIALSNELGMSGAIYYVAHHIIVQTTLFLVVGLIERQAGASSLNRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIG
KVALLEAGSLQGSVLAWALVAGGTITSLLTLYAVARVWTKAFWRPRSDAPEGDLAAAAPTALLDDAEDVAFVDRADVGRI
PAGMLAPTLGLIAVGVALTIFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=381, Percent_Identity=23.8845144356955, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI251831116, Length=304, Percent_Identity=22.3684210526316, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788829, Length=397, Percent_Identity=30.2267002518892, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI1788827, Length=340, Percent_Identity=26.7647058823529, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI145693160, Length=330, Percent_Identity=32.7272727272727, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788613, Length=355, Percent_Identity=28.4507042253521, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788831, Length=282, Percent_Identity=28.0141843971631, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788614, Length=365, Percent_Identity=30.1369863013699, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI2367154, Length=386, Percent_Identity=25.6476683937824, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 55130; Mature: 54999

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLGVCTALLYLTDRDGTF
CCCCHHHCCCCHHHCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHEECCCCEE
ALAVGGWGPTEEKLGPLGITLVVDRLSALMLVVSAIVLLAVVLYAAAQGIRDGDERQPVS
EEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
IFMPTYLALSAGVCNAFLAGDLFNLYVGFEVLLAASFVLLTIGASADRVRAGISYVMVSM
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MSSVVFLLGIAFVYAATGTLNMAEIALRADGIPSGTRMAIFAVLLVGFAIKAAVFPLSTW
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGLNTVLLVAALLTMIVGILGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IAQSDIKRLLSFTLVSHIGYMIFGIALSNELGMSGAIYYVAHHIIVQTTLFLVVGLIERQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGASSLNRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKVALLEAGSLQGSVLAWAL
CCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
VAGGTITSLLTLYAVARVWTKAFWRPRSDAPEGDLAAAAPTALLDDAEDVAFVDRADVGR
HHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHCCCCHHHEECCCCCCC
IPAGMLAPTLGLIAVGVALTIFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR
CCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCEEEEEEECCCCCC
>Mature Secondary Structure 
STMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLGVCTALLYLTDRDGTF
CCCHHHCCCCHHHCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHEECCCCEE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CCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]