Click here to switch to the map view.

The map label for this gene is hmuU [H]

Identifier: 169627653

GI number: 169627653

Start: 551313

End: 552365

Strand: Reverse

Name: hmuU [H]

Synonym: MAB_0549c

Alternate gene names: 169627653

Gene position: 552365-551313 (Counterclockwise)

Preceding gene: 169627656

Following gene: 169627652

Centisome position: 10.9

GC content: 68.47

Gene sequence:

>1053_bases
ATGCCCACAGCACAGCACACACGGTCCCTGATCCTTGCGGTGCTCGGCGGACTGGCGGCGCTGGTGCTACTGACGGTGAC
CGCACTCGCCTTCGGCACCGCCGACGTGCCCTGGCGCGACTGTCTGCATTTCTTGTGGGCCGGCGCGAGCGGAGGCTCGG
TGCCCGCCGTCGACGCCGCGAACTATCGGATCGTGGTCGAATCCAGGCTGCCGCGGGTGCTGCTGGCGGTCCTTGTCGGC
GCCGGACTCAGCGTGGTGGGCGTGATCGTGCAGGCAATGGTCCGCAACGCCCTCGCCGATCCGTACGTTCTCGGAATCTC
CTCGGGCGCCTCGGTGGGCGCGACCGCAGTGGTTGTCTACGGCGTGCTCGGTACCCTGGGCACCTATGCGCTCTCATTGT
CGGCGTCCCTGGGCGCGCTCGCCGCTACCGCCGTCGTCTACCAGATCGCGCGCACACCACAGGGATTGGTACCACTGCGA
CTGGTCCTGGTAGGCACAGCGGTCGGTTACGGGTTGTCCGCGGTGACCACGGTCCTGGTGTTCTTGGCCCCGAACGGAGA
GGCCGCCCGCAGCGTCATGTTCTGGCTGCTGGGCAGCCTGGGCGCGTCGTCCTGGGACAAGGTACCGGTGGCACTTGCCG
CGACCGTGATCGGAATCCTCTGCGCTGGCGGGCTTGCCCGCCAGCTCAACGCCCTTGCCATGGGCGACGAGGTGAGCGCG
TCGCTGGGCCTGGACGCCGGGCGATTCCGGGTGGCACTGTTCATCTTGTCGGCCGCGATGACAGGATGCTTTGTATCCAT
CTGTGGCGCGGTCGGATTCGTGGGTTTGGTCATTCCGCATGCCGCGCGGCTGCTGGTCGGCGCGGATCATCGCCGTGTCT
TGATCGTGGCGCCGGTGCTGGGCGCGTGCTTTCTGGTGGCCGCTGACCTTGTCGCGCGGACCGCGATTCCGCCGCAGGAA
CTTCCGCTCGGTGCGATCACGGCCGCGGTCGGGGTTCCGGTCTTCGTCGGATTGATGCGCCGCCGCGCGATGTCCGCGGG
GGCGGTCGGCTGA

Upstream 100 bases:

>100_bases
GTGCGGTCATTCGCCGGTGCCGAGGGACCGCCTGGCGGATAGCGCTCTTTCGCGTATCCGTCATGTCTTGGTGCGGCAAC
CCGACGACGCAGGAATGTCG

Downstream 100 bases:

>100_bases
TGGATGTCACCTTTCGGAACGTGTCCGTCAGCATCGCCGGCGCGCAGATCATTTCGGATATCCATCTGAATGTCGCGGCC
GGCGGGTTCGTCGGCATTGT

Product: putative heme/hemin ABC transporter, permease protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MPTAQHTRSLILAVLGGLAALVLLTVTALAFGTADVPWRDCLHFLWAGASGGSVPAVDAANYRIVVESRLPRVLLAVLVG
AGLSVVGVIVQAMVRNALADPYVLGISSGASVGATAVVVYGVLGTLGTYALSLSASLGALAATAVVYQIARTPQGLVPLR
LVLVGTAVGYGLSAVTTVLVFLAPNGEAARSVMFWLLGSLGASSWDKVPVALAATVIGILCAGGLARQLNALAMGDEVSA
SLGLDAGRFRVALFILSAAMTGCFVSICGAVGFVGLVIPHAARLLVGADHRRVLIVAPVLGACFLVAADLVARTAIPPQE
LPLGAITAAVGVPVFVGLMRRRAMSAGAVG

Sequences:

>Translated_350_residues
MPTAQHTRSLILAVLGGLAALVLLTVTALAFGTADVPWRDCLHFLWAGASGGSVPAVDAANYRIVVESRLPRVLLAVLVG
AGLSVVGVIVQAMVRNALADPYVLGISSGASVGATAVVVYGVLGTLGTYALSLSASLGALAATAVVYQIARTPQGLVPLR
LVLVGTAVGYGLSAVTTVLVFLAPNGEAARSVMFWLLGSLGASSWDKVPVALAATVIGILCAGGLARQLNALAMGDEVSA
SLGLDAGRFRVALFILSAAMTGCFVSICGAVGFVGLVIPHAARLLVGADHRRVLIVAPVLGACFLVAADLVARTAIPPQE
LPLGAITAAVGVPVFVGLMRRRAMSAGAVG
>Mature_349_residues
PTAQHTRSLILAVLGGLAALVLLTVTALAFGTADVPWRDCLHFLWAGASGGSVPAVDAANYRIVVESRLPRVLLAVLVGA
GLSVVGVIVQAMVRNALADPYVLGISSGASVGATAVVVYGVLGTLGTYALSLSASLGALAATAVVYQIARTPQGLVPLRL
VLVGTAVGYGLSAVTTVLVFLAPNGEAARSVMFWLLGSLGASSWDKVPVALAATVIGILCAGGLARQLNALAMGDEVSAS
LGLDAGRFRVALFILSAAMTGCFVSICGAVGFVGLVIPHAARLLVGADHRRVLIVAPVLGACFLVAADLVARTAIPPQEL
PLGAITAAVGVPVFVGLMRRRAMSAGAVG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=314, Percent_Identity=35.9872611464968, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788004, Length=280, Percent_Identity=38.9285714285714, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1790741, Length=296, Percent_Identity=34.4594594594595, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786805, Length=287, Percent_Identity=33.7979094076655, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786804, Length=269, Percent_Identity=34.5724907063197, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786347, Length=348, Percent_Identity=30.4597701149425, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35202; Mature: 35071

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAQHTRSLILAVLGGLAALVLLTVTALAFGTADVPWRDCLHFLWAGASGGSVPAVDAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
NYRIVVESRLPRVLLAVLVGAGLSVVGVIVQAMVRNALADPYVLGISSGASVGATAVVVY
CEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
GVLGTLGTYALSLSASLGALAATAVVYQIARTPQGLVPLRLVLVGTAVGYGLSAVTTVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
FLAPNGEAARSVMFWLLGSLGASSWDKVPVALAATVIGILCAGGLARQLNALAMGDEVSA
HCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHH
SLGLDAGRFRVALFILSAAMTGCFVSICGAVGFVGLVIPHAARLLVGADHRRVLIVAPVL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHH
GACFLVAADLVARTAIPPQELPLGAITAAVGVPVFVGLMRRRAMSAGAVG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PTAQHTRSLILAVLGGLAALVLLTVTALAFGTADVPWRDCLHFLWAGASGGSVPAVDAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
NYRIVVESRLPRVLLAVLVGAGLSVVGVIVQAMVRNALADPYVLGISSGASVGATAVVVY
CEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
GVLGTLGTYALSLSASLGALAATAVVYQIARTPQGLVPLRLVLVGTAVGYGLSAVTTVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
FLAPNGEAARSVMFWLLGSLGASSWDKVPVALAATVIGILCAGGLARQLNALAMGDEVSA
HCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHH
SLGLDAGRFRVALFILSAAMTGCFVSICGAVGFVGLVIPHAARLLVGADHRRVLIVAPVL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHH
GACFLVAADLVARTAIPPQELPLGAITAAVGVPVFVGLMRRRAMSAGAVG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]