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The map label for this gene is folK [H]

Identifier: 169627641

GI number: 169627641

Start: 538584

End: 539102

Strand: Direct

Name: folK [H]

Synonym: MAB_0537

Alternate gene names: 169627641

Gene position: 538584-539102 (Clockwise)

Preceding gene: 169627640

Following gene: 169627642

Centisome position: 10.63

GC content: 68.21

Gene sequence:

>519_bases
GTGCGTGCCGTGCTTTCGATCGGCTCCAATGTCGGTGACAGGCTCGCGCACCTGCAATCGGTGGTGGACGCACTGGGCTC
GGACGTGGTCGGCGTCTCGCCGGTGTATCAGACCGCTCCGTGGGGGCATGTTCCGCAGCCGGACTTCTTCAACGCAATCG
TCGTCGCCGACGGACGCGAGCCCCTGGAGTGGCTTGCGGTGGCGCACCGCCTGGAGCAGTCGGCGCAGCGATTGCGCGAC
GAGCGTTGGGGTCCAAGGACTCTCGACGTTGATGTGATCAGCTGTCGTCGCCATGATGCTGGTGAGGTCCTTTCCGATGA
CCCGGATCTCACGCTGCCGCATCCGCGTGCGCATCTGCGGGCCTTCGTGCTGGTGCCGTGGCTGGCGCTGGAGCCCGGCG
CGGTACTCACCGTCGACGGTGTGGTGCGCCCGGTGGCCGACCTGCTGTCCGGACTCGACGCGGCCGAACGCGAGGGTGTG
CGGCGGATGGATGCCGCCCTGACCGGTCCGGTGACGTAG

Upstream 100 bases:

>100_bases
CGGTGGTGCATAAGCCGAACGCGCCGATTCCGTTGACGTTCGGCGATGTGGCGGTGGTGGCCCGTCGCTCCCGGCGATCT
CGGTCCGGGGCGCGGTAGCG

Downstream 100 bases:

>100_bases
TGGGAACCACCCGCTTCCGCGATCTGCTGGTCGCGGGCGTCGTCACGGCGATCTTTTGCTATTTCTTTGTTTCGGCGGCT
TACGGATCCCTGCCGCCGAT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (FolK)

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MRAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDFFNAIVVADGREPLEWLAVAHRLEQSAQRLRD
ERWGPRTLDVDVISCRRHDAGEVLSDDPDLTLPHPRAHLRAFVLVPWLALEPGAVLTVDGVVRPVADLLSGLDAAEREGV
RRMDAALTGPVT

Sequences:

>Translated_172_residues
MRAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDFFNAIVVADGREPLEWLAVAHRLEQSAQRLRD
ERWGPRTLDVDVISCRRHDAGEVLSDDPDLTLPHPRAHLRAFVLVPWLALEPGAVLTVDGVVRPVADLLSGLDAAEREGV
RRMDAALTGPVT
>Mature_172_residues
MRAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDFFNAIVVADGREPLEWLAVAHRLEQSAQRLRD
ERWGPRTLDVDVISCRRHDAGEVLSDDPDLTLPHPRAHLRAFVLVPWLALEPGAVLTVDGVVRPVADLLSGLDAAEREGV
RRMDAALTGPVT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=149, Percent_Identity=34.8993288590604, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=32.5925925925926, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18638; Mature: 18638

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDFFNAIVVADGRE
CCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCC
PLEWLAVAHRLEQSAQRLRDERWGPRTLDVDVISCRRHDAGEVLSDDPDLTLPHPRAHLR
HHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
AFVLVPWLALEPGAVLTVDGVVRPVADLLSGLDAAEREGVRRMDAALTGPVT
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDFFNAIVVADGRE
CCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCC
PLEWLAVAHRLEQSAQRLRDERWGPRTLDVDVISCRRHDAGEVLSDDPDLTLPHPRAHLR
HHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
AFVLVPWLALEPGAVLTVDGVVRPVADLLSGLDAAEREGVRRMDAALTGPVT
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]