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The map label for this gene is sufS [H]

Identifier: 169627616

GI number: 169627616

Start: 513383

End: 514678

Strand: Direct

Name: sufS [H]

Synonym: MAB_0512

Alternate gene names: 169627616

Gene position: 513383-514678 (Clockwise)

Preceding gene: 169627611

Following gene: 169627617

Centisome position: 10.13

GC content: 66.74

Gene sequence:

>1296_bases
ATGTCAGTGTCCACACAAGCGGTGTCCGGGCAGCCATTCGCGCGGGTGGTCGGAGCCGACACCAAAGTTCCTTTGGCTCA
CGGAGGCTGGGTCAGATACGCAAACTTTGATTACGCTGCCAGCGCGCCCGCACTCTGCGATGTCGCGGACCGGGTCACCG
AACTGCTGCCGTATTACGCCAGCGTGCATCGCGGCGCGGGCTACGCCTCACGGGTCTGCACCCGGCTCTATGAGGGGGCG
CGGGAAACCGTCGGCCGTTTTGTCGGCGCCCGCGCCGACCACCACGTGATCTTTACCCGCAACACCACGGATTCGCTCAA
TCTGCTGGCGTCTGCGGTGCCAGGCGAGGTAGTTGTGCTCGATATAGAACACCACGCAAACCTGTTGACCTGGCAGCGAT
ATGGCGCCCGGGTAGTGGCGCACCGAACGACCGTGCCGGATACCGTTGCCGCGTTGGACGAGGAGCTGGCGCGCCGGCCG
ACCGCGCTGCTGGCCGTCACCGGCGCGTCCAACGTCACCGGTGAGGTACTTCCGCTCGGCGAACTCGCGGCGGCAGCCCA
CCGGAACGGAGCGCGGATCGCCGTCGACGGTGCGCAACTGGCTCCGCACCGACGAATTGACCTGGCAGCAGCCGGGATTG
ACTACTTGGCGTTCTCCGGGCACAAGCTGTACGCACCGTTCGGTGCAGGAGTCCTTGTGGGGCAAGCTGACTGGCTTGAC
ACGGCGCGGCCCTATCTGGCCGGTGGAGGCGCTGTCCGCAATGTGGATATCGATGAGGCGCAATGGTTCACCGGCCCGCA
GCGGCATGAGGCGGGTACGCCCAATGTGGTCGGGGTCGCAGCGATTGCTGCCGCGTGTGAGGCGCTGACCGTCCTCGGCG
ACCTAGGTCACGCCGAGGACGCGCTCACCGTGCAACTGCGTGATGGGCTCGAGGCGATTGAAGGCGTTGATACGCTGCGT
ATTTGGGAGGGCGATCGCGACGTACTGGGCATCGTGTCTTTTACGGTCGCCGGGTATGCGCCGTCGGTTGTCGCCGCCTA
CCTGTCAGCCGAGCACGGTATCGGGCTGCGTGACGGACGATTCTGCGCGCACCCGCTGTTGGCCAGACTCGGCGCGCCGG
GTGGTGCGCTACGGGCGAGTATCGGGCTGGGCACCACGGCCGGCGACATCGCGCGCCTGCTCGGCGCGATCAACGAACTC
GTCCGGCGCGGACCGGGCTTGGCCTACATCGAGCGTGACGGTCAGATCGGACCGGTGGACGATCCGCGCCCGCTCCCGGA
TTTCCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
CTCCACCACGGTGGGGTGCTCCAGGTGACGACCTGGCCGCGCTCAACCGTGCGTGGCAAGCGTGGACTCGCCGGGCGGGT
CCGGTGAGATGGGATGTCAC

Downstream 100 bases:

>100_bases
ATCCGCAATCCACATATCCGTAACTATTAATACGTGGTACTTTCAGTTCGACACATAACGGGTCGGACTGACAAGGACGT
CTAATGACTAGTGCGCGTGT

Product: aminotransferase/cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSVSTQAVSGQPFARVVGADTKVPLAHGGWVRYANFDYAASAPALCDVADRVTELLPYYASVHRGAGYASRVCTRLYEGA
RETVGRFVGARADHHVIFTRNTTDSLNLLASAVPGEVVVLDIEHHANLLTWQRYGARVVAHRTTVPDTVAALDEELARRP
TALLAVTGASNVTGEVLPLGELAAAAHRNGARIAVDGAQLAPHRRIDLAAAGIDYLAFSGHKLYAPFGAGVLVGQADWLD
TARPYLAGGGAVRNVDIDEAQWFTGPQRHEAGTPNVVGVAAIAAACEALTVLGDLGHAEDALTVQLRDGLEAIEGVDTLR
IWEGDRDVLGIVSFTVAGYAPSVVAAYLSAEHGIGLRDGRFCAHPLLARLGAPGGALRASIGLGTTAGDIARLLGAINEL
VRRGPGLAYIERDGQIGPVDDPRPLPDFLAA

Sequences:

>Translated_431_residues
MSVSTQAVSGQPFARVVGADTKVPLAHGGWVRYANFDYAASAPALCDVADRVTELLPYYASVHRGAGYASRVCTRLYEGA
RETVGRFVGARADHHVIFTRNTTDSLNLLASAVPGEVVVLDIEHHANLLTWQRYGARVVAHRTTVPDTVAALDEELARRP
TALLAVTGASNVTGEVLPLGELAAAAHRNGARIAVDGAQLAPHRRIDLAAAGIDYLAFSGHKLYAPFGAGVLVGQADWLD
TARPYLAGGGAVRNVDIDEAQWFTGPQRHEAGTPNVVGVAAIAAACEALTVLGDLGHAEDALTVQLRDGLEAIEGVDTLR
IWEGDRDVLGIVSFTVAGYAPSVVAAYLSAEHGIGLRDGRFCAHPLLARLGAPGGALRASIGLGTTAGDIARLLGAINEL
VRRGPGLAYIERDGQIGPVDDPRPLPDFLAA
>Mature_430_residues
SVSTQAVSGQPFARVVGADTKVPLAHGGWVRYANFDYAASAPALCDVADRVTELLPYYASVHRGAGYASRVCTRLYEGAR
ETVGRFVGARADHHVIFTRNTTDSLNLLASAVPGEVVVLDIEHHANLLTWQRYGARVVAHRTTVPDTVAALDEELARRPT
ALLAVTGASNVTGEVLPLGELAAAAHRNGARIAVDGAQLAPHRRIDLAAAGIDYLAFSGHKLYAPFGAGVLVGQADWLDT
ARPYLAGGGAVRNVDIDEAQWFTGPQRHEAGTPNVVGVAAIAAACEALTVLGDLGHAEDALTVQLRDGLEAIEGVDTLRI
WEGDRDVLGIVSFTVAGYAPSVVAAYLSAEHGIGLRDGRFCAHPLLARLGAPGGALRASIGLGTTAGDIARLLGAINELV
RRGPGLAYIERDGQIGPVDDPRPLPDFLAA

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI156713448, Length=434, Percent_Identity=23.963133640553, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787970, Length=389, Percent_Identity=33.4190231362468, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1789175, Length=355, Percent_Identity=37.4647887323944, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319831, Length=187, Percent_Identity=27.807486631016, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 45149; Mature: 45018

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSTQAVSGQPFARVVGADTKVPLAHGGWVRYANFDYAASAPALCDVADRVTELLPYYA
CCCCCCCCCCCCHHHEECCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
SVHRGAGYASRVCTRLYEGARETVGRFVGARADHHVIFTRNTTDSLNLLASAVPGEVVVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEE
DIEHHANLLTWQRYGARVVAHRTTVPDTVAALDEELARRPTALLAVTGASNVTGEVLPLG
EECCCCCEEEHHHHCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEHH
ELAAAAHRNGARIAVDGAQLAPHRRIDLAAAGIDYLAFSGHKLYAPFGAGVLVGQADWLD
HHHHHHCCCCCEEEECCHHCCCCCCEEEECCCCHHEEECCCEEECCCCCCEEEECCHHHH
TARPYLAGGGAVRNVDIDEAQWFTGPQRHEAGTPNVVGVAAIAAACEALTVLGDLGHAED
CCCCHHCCCCEEEECCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
ALTVQLRDGLEAIEGVDTLRIWEGDRDVLGIVSFTVAGYAPSVVAAYLSAEHGIGLRDGR
EEEEEEHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
FCAHPLLARLGAPGGALRASIGLGTTAGDIARLLGAINELVRRGPGLAYIERDGQIGPVD
HHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
DPRPLPDFLAA
CCCCCHHHHCC
>Mature Secondary Structure 
SVSTQAVSGQPFARVVGADTKVPLAHGGWVRYANFDYAASAPALCDVADRVTELLPYYA
CCCCCCCCCCCHHHEECCCCCCEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
SVHRGAGYASRVCTRLYEGARETVGRFVGARADHHVIFTRNTTDSLNLLASAVPGEVVVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEE
DIEHHANLLTWQRYGARVVAHRTTVPDTVAALDEELARRPTALLAVTGASNVTGEVLPLG
EECCCCCEEEHHHHCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEHH
ELAAAAHRNGARIAVDGAQLAPHRRIDLAAAGIDYLAFSGHKLYAPFGAGVLVGQADWLD
HHHHHHCCCCCEEEECCHHCCCCCCEEEECCCCHHEEECCCEEECCCCCCEEEECCHHHH
TARPYLAGGGAVRNVDIDEAQWFTGPQRHEAGTPNVVGVAAIAAACEALTVLGDLGHAED
CCCCHHCCCCEEEECCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
ALTVQLRDGLEAIEGVDTLRIWEGDRDVLGIVSFTVAGYAPSVVAAYLSAEHGIGLRDGR
EEEEEEHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
FCAHPLLARLGAPGGALRASIGLGTTAGDIARLLGAINELVRRGPGLAYIERDGQIGPVD
HHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
DPRPLPDFLAA
CCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA