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The map label for this gene is gloB [H]

Identifier: 169627518

GI number: 169627518

Start: 414855

End: 415640

Strand: Direct

Name: gloB [H]

Synonym: MAB_0414

Alternate gene names: 169627518

Gene position: 414855-415640 (Clockwise)

Preceding gene: 169627517

Following gene: 169627519

Centisome position: 8.19

GC content: 67.3

Gene sequence:

>786_bases
GTGCACCCCGCCTACGGGCAACTGCGGCCGGTCACCGAGACCGCCTCGGTGCTGCTGGCCAATAACCCGGGGATGATGAC
GCTTGAGGGCACCAACACCTGGGTGTTGCGTGCACCGGGCAGCGACGAGATCGTGATCGTCGATCCGGGCCCCGGAGTGG
CCACCGGTGATCCCGACGTGCACGTCGAGCAGCTCGCCAAGATCGGCAAGGTGGCCCTGGTACTGGTGAGCCACCGGCAT
TTCGATCACACCGGTGGTGTCGACCGGCTGGTCGAACTGACCGGCGCCCCGGCGCGTGCGGTGGATCCGGCATGGCTGCG
TGGCGACTCGGTGGCGCTGACAGACGGCGAGCGCATCGACGTCGCGGGGTTGTCGATCTCGGTGCTGGCCACGCCCGGGC
ACAGCGACGATTCGGTGTCCTTCGTTCTGGACGACGCGGTGCTGACGGCCGACACCATCCTGGGTCGGGGTACCACGGTG
ATCGCACAGGACGGCGGGGGTCTCGGTGACTACTTGGAATCTTTGAAACGCCTTGAGGGTCTGGGTAAGCGGACCGTGCT
GCCCGGCCACGGCCCGGAACTGAGCGATCTGTCGGCGGCATCGGCCGAATACCTGGCCCACCGCGAGCAGCGTTTGGACC
AGGTGCGCGCGGCGCTGGCGGCGCTGGGAGAAGACGCCTCGGCACGGCAGGTTGTCGAATTCGTGTACACCGATGTGGAC
CCGTCGCTGTGGGGTGCGGCCGAATGGTCGGTCCAGGCGCAACTGGACTACCTGCGTACTGTTTAG

Upstream 100 bases:

>100_bases
GCGTGCATGCGCGTTCGGCGGTTGGTGTTGCCGAGTTGCCGATCAACGCCCCCGTGGAAGTCGAGATCGTGGTGGAGGTC
CGAGAGGAAGTGTCCGCATA

Downstream 100 bases:

>100_bases
CCAGCGGTGAACTCGATTCCCCTTGCCCTCGCGGGCTCACTGAGCTGGGGCATCAGTGACTTCATCGGCGGGCATGCGAG
CAAGCGGCGGTCGACCCTGG

Product: beta-lactamase-like hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MHPAYGQLRPVTETASVLLANNPGMMTLEGTNTWVLRAPGSDEIVIVDPGPGVATGDPDVHVEQLAKIGKVALVLVSHRH
FDHTGGVDRLVELTGAPARAVDPAWLRGDSVALTDGERIDVAGLSISVLATPGHSDDSVSFVLDDAVLTADTILGRGTTV
IAQDGGGLGDYLESLKRLEGLGKRTVLPGHGPELSDLSAASAEYLAHREQRLDQVRAALAALGEDASARQVVEFVYTDVD
PSLWGAAEWSVQAQLDYLRTV

Sequences:

>Translated_261_residues
MHPAYGQLRPVTETASVLLANNPGMMTLEGTNTWVLRAPGSDEIVIVDPGPGVATGDPDVHVEQLAKIGKVALVLVSHRH
FDHTGGVDRLVELTGAPARAVDPAWLRGDSVALTDGERIDVAGLSISVLATPGHSDDSVSFVLDDAVLTADTILGRGTTV
IAQDGGGLGDYLESLKRLEGLGKRTVLPGHGPELSDLSAASAEYLAHREQRLDQVRAALAALGEDASARQVVEFVYTDVD
PSLWGAAEWSVQAQLDYLRTV
>Mature_261_residues
MHPAYGQLRPVTETASVLLANNPGMMTLEGTNTWVLRAPGSDEIVIVDPGPGVATGDPDVHVEQLAKIGKVALVLVSHRH
FDHTGGVDRLVELTGAPARAVDPAWLRGDSVALTDGERIDVAGLSISVLATPGHSDDSVSFVLDDAVLTADTILGRGTTV
IAQDGGGLGDYLESLKRLEGLGKRTVLPGHGPELSDLSAASAEYLAHREQRLDQVRAALAALGEDASARQVVEFVYTDVD
PSLWGAAEWSVQAQLDYLRTV

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI7705793, Length=252, Percent_Identity=29.7619047619048, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193205216, Length=256, Percent_Identity=29.6875, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17537503, Length=256, Percent_Identity=29.6875, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI20129357, Length=270, Percent_Identity=30.3703703703704, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 27524; Mature: 27524

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPAYGQLRPVTETASVLLANNPGMMTLEGTNTWVLRAPGSDEIVIVDPGPGVATGDPDV
CCCCCCCCEECCCCEEEEEECCCCEEEECCCCEEEEECCCCCCEEEECCCCCCCCCCCCC
HVEQLAKIGKVALVLVSHRHFDHTGGVDRLVELTGAPARAVDPAWLRGDSVALTDGERID
HHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCHHCCCCEEEECCCCEEE
VAGLSISVLATPGHSDDSVSFVLDDAVLTADTILGRGTTVIAQDGGGLGDYLESLKRLEG
EECCEEEEEECCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHC
LGKRTVLPGHGPELSDLSAASAEYLAHREQRLDQVRAALAALGEDASARQVVEFVYTDVD
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
PSLWGAAEWSVQAQLDYLRTV
CCCCCCCCEEHHHHHHHHHCC
>Mature Secondary Structure
MHPAYGQLRPVTETASVLLANNPGMMTLEGTNTWVLRAPGSDEIVIVDPGPGVATGDPDV
CCCCCCCCEECCCCEEEEEECCCCEEEECCCCEEEEECCCCCCEEEECCCCCCCCCCCCC
HVEQLAKIGKVALVLVSHRHFDHTGGVDRLVELTGAPARAVDPAWLRGDSVALTDGERID
HHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCHHCCCCEEEECCCCEEE
VAGLSISVLATPGHSDDSVSFVLDDAVLTADTILGRGTTVIAQDGGGLGDYLESLKRLEG
EECCEEEEEECCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHC
LGKRTVLPGHGPELSDLSAASAEYLAHREQRLDQVRAALAALGEDASARQVVEFVYTDVD
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
PSLWGAAEWSVQAQLDYLRTV
CCCCCCCCEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA