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The map label for this gene is cysM [C]

Identifier: 169627510

GI number: 169627510

Start: 406764

End: 407834

Strand: Reverse

Name: cysM [C]

Synonym: MAB_0406c

Alternate gene names: 169627510

Gene position: 407834-406764 (Counterclockwise)

Preceding gene: 169627511

Following gene: 169627509

Centisome position: 8.05

GC content: 64.15

Gene sequence:

>1071_bases
GTGAGCCGTGCATGGGCCGATAACGCGGTTCGATTGATCGAGGCCGACGCCCGTCGCAGTGCCGATACCCATCTGCTGCG
ATATCCGCTGCCCGCGGCATGGGCCGACACCGTGGATGTGCAGTTGTATCTCAAGGACGAGTCGACGCACATCACCGGCA
GCCTGAAACATCGTTTGGCGCGTTCACTTTTCCTGTACGCACTGTGCAACGGGTTCATCGGCGAGAACACCACCATCGTG
GAGGCCTCTTCCGGGTCGACGGCGGTCTCGGAGGCCTATTTCGCACAGCTGCTCGGGTTGCCGTTCATCGCGGTGATGAC
GGCCTCGACCAGCCCCAGTAAGATCGCATTGATCGAATCACAGGGTGGCCGTTGTCATTTCGTCGATGAAGCGCAACAGG
TGTACGCCGAGGCGCAGCGGCTCGCCGACGAGACCGGTGGCCACTATCTGGACCAGTTCACCAACGCCGAACGAGCCACC
GACTGGCGCGGCAACAACAACATCGCCGAGTCGATCTTTACCCAGATGCATCACGAAAAGCACCCGCTGCCAACGTGGAT
CGTGGTCGGCGCGGGCACCGGCGGCACCAGCGCAACCATCGGCCGCTACATCCGGTACCGGCGCTACCCCACTCAGTTAT
GCGTGGTGGATCCGGACAACTCCGCGTTCTATCCCTCGTATCTCGCCAGACGTGATGTGGTGACAGGGATTTCGTCGCGA
ATCGAGGGCATTGGCCGGCCCCGTGTCGAGCCGTCGTTCCTGCCGTCGGTGGTGGACCGCATGGAGCAGATACCCGACGC
CTACTCGGTGGCGCTCACCCGGCATGCCAGCGCGGTACTGGGCCGCCGGGTGGGTGCGTCGACGGGAACCAACCTGTGCG
GCGCGTTCCGGCTGATCTCGGAGATGGCCGCCACCGGCCTCGGCGGTTCGGTGGTGACGCTGCTGGCCGATAGCGGCGAC
CGATACGCCGACACCTATTTCAACGACGACTGGGTGACCGAGCAGGGGTTCGATCTGCTGGGGCCGTCGGTACGGCTGGC
CGAGTTCGAGGATGCCGGGCGCTGGGACTAG

Upstream 100 bases:

>100_bases
CCGGAGGCGACACTGCTGACCCTGGTTCCGGCTCGCACCAGCGGCCACGGGGCCGACGCCGAATCCGGCGATCGCTCGCC
CAGCGCCACCGTGCAGTGAC

Downstream 100 bases:

>100_bases
CCCGGGCGCCACGTTGCGTACGCGACGTGCGGCGTGTTTCCGTGCGCGACGCCGCACTCGACGGCAGGTCACAGGCCTGC
TGACCAACGCATTCGCGACC

Product: cysteine synthase/cystathionine beta-synthase family protein

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSRAWADNAVRLIEADARRSADTHLLRYPLPAAWADTVDVQLYLKDESTHITGSLKHRLARSLFLYALCNGFIGENTTIV
EASSGSTAVSEAYFAQLLGLPFIAVMTASTSPSKIALIESQGGRCHFVDEAQQVYAEAQRLADETGGHYLDQFTNAERAT
DWRGNNNIAESIFTQMHHEKHPLPTWIVVGAGTGGTSATIGRYIRYRRYPTQLCVVDPDNSAFYPSYLARRDVVTGISSR
IEGIGRPRVEPSFLPSVVDRMEQIPDAYSVALTRHASAVLGRRVGASTGTNLCGAFRLISEMAATGLGGSVVTLLADSGD
RYADTYFNDDWVTEQGFDLLGPSVRLAEFEDAGRWD

Sequences:

>Translated_356_residues
MSRAWADNAVRLIEADARRSADTHLLRYPLPAAWADTVDVQLYLKDESTHITGSLKHRLARSLFLYALCNGFIGENTTIV
EASSGSTAVSEAYFAQLLGLPFIAVMTASTSPSKIALIESQGGRCHFVDEAQQVYAEAQRLADETGGHYLDQFTNAERAT
DWRGNNNIAESIFTQMHHEKHPLPTWIVVGAGTGGTSATIGRYIRYRRYPTQLCVVDPDNSAFYPSYLARRDVVTGISSR
IEGIGRPRVEPSFLPSVVDRMEQIPDAYSVALTRHASAVLGRRVGASTGTNLCGAFRLISEMAATGLGGSVVTLLADSGD
RYADTYFNDDWVTEQGFDLLGPSVRLAEFEDAGRWD
>Mature_355_residues
SRAWADNAVRLIEADARRSADTHLLRYPLPAAWADTVDVQLYLKDESTHITGSLKHRLARSLFLYALCNGFIGENTTIVE
ASSGSTAVSEAYFAQLLGLPFIAVMTASTSPSKIALIESQGGRCHFVDEAQQVYAEAQRLADETGGHYLDQFTNAERATD
WRGNNNIAESIFTQMHHEKHPLPTWIVVGAGTGGTSATIGRYIRYRRYPTQLCVVDPDNSAFYPSYLARRDVVTGISSRI
EGIGRPRVEPSFLPSVVDRMEQIPDAYSVALTRHASAVLGRRVGASTGTNLCGAFRLISEMAATGLGGSVVTLLADSGDR
YADTYFNDDWVTEQGFDLLGPSVRLAEFEDAGRWD

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=308, Percent_Identity=25.974025974026, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI295821200, Length=308, Percent_Identity=25.974025974026, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4557415, Length=308, Percent_Identity=25.974025974026, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI2367138, Length=293, Percent_Identity=25.5972696245734, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71996324, Length=358, Percent_Identity=33.5195530726257, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17539800, Length=365, Percent_Identity=30.1369863013699, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17539640, Length=358, Percent_Identity=27.6536312849162, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321449, Length=317, Percent_Identity=24.6056782334385, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643623, Length=321, Percent_Identity=27.4143302180685, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI20129101, Length=321, Percent_Identity=27.4143302180685, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38979; Mature: 38848

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAWADNAVRLIEADARRSADTHLLRYPLPAAWADTVDVQLYLKDESTHITGSLKHRLA
CCCCCCCCCCEEEEHHHHCCCCCEEEECCCCCCCCCCEEEEEEEECCCCEEHHHHHHHHH
RSLFLYALCNGFIGENTTIVEASSGSTAVSEAYFAQLLGLPFIAVMTASTSPSKIALIES
HHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEC
QGGRCHFVDEAQQVYAEAQRLADETGGHYLDQFTNAERATDWRGNNNIAESIFTQMHHEK
CCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
HPLPTWIVVGAGTGGTSATIGRYIRYRRYPTQLCVVDPDNSAFYPSYLARRDVVTGISSR
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
IEGIGRPRVEPSFLPSVVDRMEQIPDAYSVALTRHASAVLGRRVGASTGTNLCGAFRLIS
HHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EMAATGLGGSVVTLLADSGDRYADTYFNDDWVTEQGFDLLGPSVRLAEFEDAGRWD
HHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCHHCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SRAWADNAVRLIEADARRSADTHLLRYPLPAAWADTVDVQLYLKDESTHITGSLKHRLA
CCCCCCCCCEEEEHHHHCCCCCEEEECCCCCCCCCCEEEEEEEECCCCEEHHHHHHHHH
RSLFLYALCNGFIGENTTIVEASSGSTAVSEAYFAQLLGLPFIAVMTASTSPSKIALIES
HHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEC
QGGRCHFVDEAQQVYAEAQRLADETGGHYLDQFTNAERATDWRGNNNIAESIFTQMHHEK
CCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
HPLPTWIVVGAGTGGTSATIGRYIRYRRYPTQLCVVDPDNSAFYPSYLARRDVVTGISSR
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
IEGIGRPRVEPSFLPSVVDRMEQIPDAYSVALTRHASAVLGRRVGASTGTNLCGAFRLIS
HHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EMAATGLGGSVVTLLADSGDRYADTYFNDDWVTEQGFDLLGPSVRLAEFEDAGRWD
HHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCHHCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]