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The map label for this gene is fabG [C]

Identifier: 169627484

GI number: 169627484

Start: 376186

End: 377064

Strand: Direct

Name: fabG [C]

Synonym: MAB_0380

Alternate gene names: 169627484

Gene position: 376186-377064 (Clockwise)

Preceding gene: 169627483

Following gene: 169627485

Centisome position: 7.42

GC content: 66.67

Gene sequence:

>879_bases
ATGGGACAACTTGACGGGCGGGTGGCGGTCATCACCGGTGCCGGGCGCGGCATCGGTCGTGAGCACGCCCTGCTCTTCGC
CAAGGAAGGTGCTTCGGTGGTCGTCAACGACCTCGGTGGCGCCAATGACGGCTCCGGCTCGGATGCCGGGCCCGCACAGG
AAGTGGTGGACGAGATCACCGCGGCGGGAGGCAAAGCCGTTGCGAATACCGACAACATCTCCACGTGGGCCGGCGCCTCG
AACCTGGTGAACCAGGCCGTCGAGACCTTCGGGCAGCTGGATGCCGTGGTGAACAACGCGGGCATCCTCCGTGACGGTTT
CATCGCCGGCCTTGAGGAAGAACAGTGGGACGCGGTTATCCAGGTCCACCTCAAGGGGCATTTCGCGGTGCTACGCCACG
CCGCCGAATACTGGAAGGGGCAGGCCAAGGCCGGCGCCGATATCAAGGCCACCGTGGTGAACACGGCATCGGACTCCGGT
GTGACGCTGCCGAACCCGGGCCAGGGCAACTATGGTGCCGCCAAGGCGGGCATCGCGGCCCTGTCCTGTGTCGCGGCCGC
CGAACTGGAGCGCTACGGCGTCAAGGTGAATGCCATTGCGCCGGTTGCCCGCACCCGCCTCACGCTGGCGACCCCCGGTA
TGGGTGCCATCTTCGCGGCTCCGGTGGAGGAGGGGGCGTTCGATATGTTCAGCCCCGCGAACATATCCCCGCTGGTGGCA
TACCTGAGTACCGAGAAGAACCCGTGGACCGGGCAGGTCTTCAAGGTCACGGGCGGTTCGATCCAGCGGCTCAAGGGCTG
GTCGGTCACCGACACCGCCGAGACCGACGGGCCGTGGAGCATCGACCTGGTGCGCGACAGCATCGAGCCCTGGAAGTAG

Upstream 100 bases:

>100_bases
GAGACCAACGTCGGCGAGGACCTCGTCATCAAAAACGGCCACGCCGTTATCGCCTGAGACATCGCAGCTGAGACATCGCA
TAAGGAGAGGGAAATACATC

Downstream 100 bases:

>100_bases
CCAGTCGGTAGCGAATAGCCCTCCGCGCGCGGAGGGCTATTCGGCGTTTCGGGGCGTGCCCAGCGCAGCTCGCACCTAGA
TTCGGTGATATGCGGAACAT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MGQLDGRVAVITGAGRGIGREHALLFAKEGASVVVNDLGGANDGSGSDAGPAQEVVDEITAAGGKAVANTDNISTWAGAS
NLVNQAVETFGQLDAVVNNAGILRDGFIAGLEEEQWDAVIQVHLKGHFAVLRHAAEYWKGQAKAGADIKATVVNTASDSG
VTLPNPGQGNYGAAKAGIAALSCVAAAELERYGVKVNAIAPVARTRLTLATPGMGAIFAAPVEEGAFDMFSPANISPLVA
YLSTEKNPWTGQVFKVTGGSIQRLKGWSVTDTAETDGPWSIDLVRDSIEPWK

Sequences:

>Translated_292_residues
MGQLDGRVAVITGAGRGIGREHALLFAKEGASVVVNDLGGANDGSGSDAGPAQEVVDEITAAGGKAVANTDNISTWAGAS
NLVNQAVETFGQLDAVVNNAGILRDGFIAGLEEEQWDAVIQVHLKGHFAVLRHAAEYWKGQAKAGADIKATVVNTASDSG
VTLPNPGQGNYGAAKAGIAALSCVAAAELERYGVKVNAIAPVARTRLTLATPGMGAIFAAPVEEGAFDMFSPANISPLVA
YLSTEKNPWTGQVFKVTGGSIQRLKGWSVTDTAETDGPWSIDLVRDSIEPWK
>Mature_291_residues
GQLDGRVAVITGAGRGIGREHALLFAKEGASVVVNDLGGANDGSGSDAGPAQEVVDEITAAGGKAVANTDNISTWAGASN
LVNQAVETFGQLDAVVNNAGILRDGFIAGLEEEQWDAVIQVHLKGHFAVLRHAAEYWKGQAKAGADIKATVVNTASDSGV
TLPNPGQGNYGAAKAGIAALSCVAAAELERYGVKVNAIAPVARTRLTLATPGMGAIFAAPVEEGAFDMFSPANISPLVAY
LSTEKNPWTGQVFKVTGGSIQRLKGWSVTDTAETDGPWSIDLVRDSIEPWK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=268, Percent_Identity=41.044776119403, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI15277342, Length=272, Percent_Identity=33.0882352941176, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1787335, Length=264, Percent_Identity=30.6818181818182, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1789208, Length=202, Percent_Identity=29.7029702970297, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082100, Length=201, Percent_Identity=29.3532338308458, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787905, Length=273, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367175, Length=205, Percent_Identity=33.6585365853659, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=28.1853281853282, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1786812, Length=192, Percent_Identity=30.7291666666667, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789378, Length=270, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790717, Length=212, Percent_Identity=30.6603773584906, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082160, Length=209, Percent_Identity=27.7511961722488, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789057, Length=273, Percent_Identity=27.4725274725275, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=266, Percent_Identity=38.7218045112782, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI25147288, Length=260, Percent_Identity=31.9230769230769, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=286, Percent_Identity=27.972027972028, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=284, Percent_Identity=28.169014084507, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=210, Percent_Identity=29.0476190476191, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=30.1158301158301, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=282, Percent_Identity=27.6595744680851, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531453, Length=208, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=208, Percent_Identity=28.3653846153846, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=288, Percent_Identity=28.125, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=262, Percent_Identity=26.7175572519084, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=206, Percent_Identity=29.126213592233, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=221, Percent_Identity=28.0542986425339, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=205, Percent_Identity=27.3170731707317, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=268, Percent_Identity=28.7313432835821, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=204, Percent_Identity=28.4313725490196, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=283, Percent_Identity=24.7349823321555, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=270, Percent_Identity=27.037037037037, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=294, Percent_Identity=25.1700680272109, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=203, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=208, Percent_Identity=24.0384615384615, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=208, Percent_Identity=26.4423076923077, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=261, Percent_Identity=39.8467432950192, Blast_Score=168, Evalue=8e-43,
Organism=Drosophila melanogaster, GI18859837, Length=287, Percent_Identity=38.6759581881533, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24639444, Length=267, Percent_Identity=31.8352059925094, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI23397609, Length=204, Percent_Identity=30.8823529411765, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644339, Length=197, Percent_Identity=28.4263959390863, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357041, Length=204, Percent_Identity=29.9019607843137, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28571526, Length=202, Percent_Identity=28.2178217821782, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21357673, Length=201, Percent_Identity=29.3532338308458, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30123; Mature: 29992

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQLDGRVAVITGAGRGIGREHALLFAKEGASVVVNDLGGANDGSGSDAGPAQEVVDEIT
CCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
AAGGKAVANTDNISTWAGASNLVNQAVETFGQLDAVVNNAGILRDGFIAGLEEEQWDAVI
HCCCCEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEECCHHCCCCCCCCCEEE
QVHLKGHFAVLRHAAEYWKGQAKAGADIKATVVNTASDSGVTLPNPGQGNYGAAKAGIAA
EEEECCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
LSCVAAAELERYGVKVNAIAPVARTRLTLATPGMGAIFAAPVEEGAFDMFSPANISPLVA
HHHHHHHHHHHHCEEEEEECCHHHCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCHHHH
YLSTEKNPWTGQVFKVTGGSIQRLKGWSVTDTAETDGPWSIDLVRDSIEPWK
EEECCCCCCCCEEEEECCCCEEHCCCCCCCCCCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
GQLDGRVAVITGAGRGIGREHALLFAKEGASVVVNDLGGANDGSGSDAGPAQEVVDEIT
CCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
AAGGKAVANTDNISTWAGASNLVNQAVETFGQLDAVVNNAGILRDGFIAGLEEEQWDAVI
HCCCCEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEECCHHCCCCCCCCCEEE
QVHLKGHFAVLRHAAEYWKGQAKAGADIKATVVNTASDSGVTLPNPGQGNYGAAKAGIAA
EEEECCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
LSCVAAAELERYGVKVNAIAPVARTRLTLATPGMGAIFAAPVEEGAFDMFSPANISPLVA
HHHHHHHHHHHHCEEEEEECCHHHCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCHHHH
YLSTEKNPWTGQVFKVTGGSIQRLKGWSVTDTAETDGPWSIDLVRDSIEPWK
EEECCCCCCCCEEEEECCCCEEHCCCCCCCCCCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]