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The map label for this gene is pat

Identifier: 169627325

GI number: 169627325

Start: 232161

End: 233204

Strand: Reverse

Name: pat

Synonym: MAB_0220c

Alternate gene names: 169627325

Gene position: 233204-232161 (Counterclockwise)

Preceding gene: 169627326

Following gene: 169627323

Centisome position: 4.6

GC content: 67.15

Gene sequence:

>1044_bases
GTGCCCGCACGACTTCGCCCCGAACTGACCGAACTACCGGCCTACACACCGGGCCGAAACGTCCCCGGCGCCATCAAGCT
CGCCAGTAATGAGACCGTGCAGGAGCCGCTGCCGAGCGTGCGGGCCGCCCTCGCCGAGGCGGGGTCGCTGATCAATCGGT
ACCCCGATAATGGCTACGCCGAGCTGCGCTCGCACCTGGCCAAGCACGTCGACATGCCGCCCGAGCACATCGCGGTGGGG
TGCGGGTCGGTGAGCCTATGCCAGCAGCTGGTCCAGATCACCGCAACGGTGGGCGACGAGGTGCTGTTCGGCTGGCGGTC
CTTTGAGACCTATCCGTTGGTGGTGCGGGTCGCGGGGGCGACTCCGGTGCAGGTACCGCTGGTCGACCACACCTATGACC
TCGCCGCCATGGCGGCCGCCGTAACCGACGTCACCCGGCTGATCTTCGTCTGCAACCCCAACAACCCGACCGGCACCGTG
GTGCGGCCCGCCGAACTGCGGCGGTTCGTCGAGTCGGTGCCGCCGCATATCCTGATCGCGATCGACGAGGCCTACGTCGA
GTACGTACGCGAGGACTTCACCGACAGCCTCGCACTGGTGCGTGAGCACCCCAATGTCGTTGTCTTACGCACCTTCTCAA
AGGCATACGGCCTGGCGGGGCTGCGAGTCGGCTACGCGGTCGGCGATCCCGATGTGATCACCACACTGGGCAAGGTGTAC
GTACCGTTCAGCGCGTCGAGCCTGGCGCAAGCTGCCGCGGTGGCTTCCCTCGGCGCCGCCGAAGAGCTGCTCGCGCGCAC
CAATGACGTTGTCACCGAACGCGCCCGGGTGACCAGTGCGCTGCGGGAAGCCGGCTATCAGGTGCCGCCGTCGCAGGCGA
ACTTCGTGTGGTTGCCGCTGGGCGAGCGCTCCACCGAATTCGCGCAAGCCTCCGCCGAGGCCCGAATCATTGTGCGCCCC
TTTGGAACCGATGGCGTCCGGGTGACCATCGGAGCACCGATGGAAAACGACGCGTTCCTGAAGTTCTCGCGCGCCTGGCG
CTAG

Upstream 100 bases:

>100_bases
GGATCCCGAACCGCCGAGGGCACAGAGTACAGGGCCGCGCGCCCCAAAGGCAAAGCCGTTGGTCGTCATCGGGCCCCACG
TGCCCCGATAGTCTGGTCAC

Downstream 100 bases:

>100_bases
CTCACCCGCGACAGTTCCGCGGCCGGGGCCCATTCGACCGTCAATTCCACGACGTCATGTGCACCGGGATGTACCAGCGC
CAAGGGGGTCAACGGCCCGT

Product: putative aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MPARLRPELTELPAYTPGRNVPGAIKLASNETVQEPLPSVRAALAEAGSLINRYPDNGYAELRSHLAKHVDMPPEHIAVG
CGSVSLCQQLVQITATVGDEVLFGWRSFETYPLVVRVAGATPVQVPLVDHTYDLAAMAAAVTDVTRLIFVCNPNNPTGTV
VRPAELRRFVESVPPHILIAIDEAYVEYVREDFTDSLALVREHPNVVVLRTFSKAYGLAGLRVGYAVGDPDVITTLGKVY
VPFSASSLAQAAAVASLGAAEELLARTNDVVTERARVTSALREAGYQVPPSQANFVWLPLGERSTEFAQASAEARIIVRP
FGTDGVRVTIGAPMENDAFLKFSRAWR

Sequences:

>Translated_347_residues
MPARLRPELTELPAYTPGRNVPGAIKLASNETVQEPLPSVRAALAEAGSLINRYPDNGYAELRSHLAKHVDMPPEHIAVG
CGSVSLCQQLVQITATVGDEVLFGWRSFETYPLVVRVAGATPVQVPLVDHTYDLAAMAAAVTDVTRLIFVCNPNNPTGTV
VRPAELRRFVESVPPHILIAIDEAYVEYVREDFTDSLALVREHPNVVVLRTFSKAYGLAGLRVGYAVGDPDVITTLGKVY
VPFSASSLAQAAAVASLGAAEELLARTNDVVTERARVTSALREAGYQVPPSQANFVWLPLGERSTEFAQASAEARIIVRP
FGTDGVRVTIGAPMENDAFLKFSRAWR
>Mature_346_residues
PARLRPELTELPAYTPGRNVPGAIKLASNETVQEPLPSVRAALAEAGSLINRYPDNGYAELRSHLAKHVDMPPEHIAVGC
GSVSLCQQLVQITATVGDEVLFGWRSFETYPLVVRVAGATPVQVPLVDHTYDLAAMAAAVTDVTRLIFVCNPNNPTGTVV
RPAELRRFVESVPPHILIAIDEAYVEYVREDFTDSLALVREHPNVVVLRTFSKAYGLAGLRVGYAVGDPDVITTLGKVYV
PFSASSLAQAAAVASLGAAEELLARTNDVVTERARVTSALREAGYQVPPSQANFVWLPLGERSTEFAQASAEARIIVRPF
GTDGVRVTIGAPMENDAFLKFSRAWR

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Escherichia coli, GI1788332, Length=310, Percent_Identity=28.3870967741935, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786816, Length=216, Percent_Identity=27.3148148148148, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788722, Length=276, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=169, Percent_Identity=28.4023668639053, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=169, Percent_Identity=28.4023668639053, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=377, Percent_Identity=23.6074270557029, Blast_Score=96, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PATR_MYCA9 (B1MFC0)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001700974.1
- ProteinModelPortal:   B1MFC0
- SMR:   B1MFC0
- EnsemblBacteria:   EBMYCT00000007152
- GeneID:   5962763
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_0220c
- GeneTree:   EBGT00070000031717
- HOGENOM:   HBG646350
- OMA:   YAFELRT
- ProtClustDB:   PRK03321
- BioCyc:   MABS561007:MAB_0220C-MONOMER
- HAMAP:   MF_01513
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.9

Molecular weight: Translated: 37500; Mature: 37369

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARLRPELTELPAYTPGRNVPGAIKLASNETVQEPLPSVRAALAEAGSLINRYPDNGYA
CCCCCCCCHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELRSHLAKHVDMPPEHIAVGCGSVSLCQQLVQITATVGDEVLFGWRSFETYPLVVRVAGA
HHHHHHHHHCCCCHHHEEECCCHHHHHHHHHHHHHHCCHHHEECHHCCCCCEEEEEEECC
TPVQVPLVDHTYDLAAMAAAVTDVTRLIFVCNPNNPTGTVVRPAELRRFVESVPPHILIA
CCEEEEEECCCHHHHHHHHHHHHHEEEEEEECCCCCCCCEECHHHHHHHHHHCCCEEEEE
IDEAYVEYVREDFTDSLALVREHPNVVVLRTFSKAYGLAGLRVGYAVGDPDVITTLGKVY
ECHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCCEEEEEECCCCHHHHHHHHEE
VPFSASSLAQAAAVASLGAAEELLARTNDVVTERARVTSALREAGYQVPPSQANFVWLPL
ECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
GERSTEFAQASAEARIIVRPFGTDGVRVTIGAPMENDAFLKFSRAWR
CCCCHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCCCEEEECCCCC
>Mature Secondary Structure 
PARLRPELTELPAYTPGRNVPGAIKLASNETVQEPLPSVRAALAEAGSLINRYPDNGYA
CCCCCCCHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELRSHLAKHVDMPPEHIAVGCGSVSLCQQLVQITATVGDEVLFGWRSFETYPLVVRVAGA
HHHHHHHHHCCCCHHHEEECCCHHHHHHHHHHHHHHCCHHHEECHHCCCCCEEEEEEECC
TPVQVPLVDHTYDLAAMAAAVTDVTRLIFVCNPNNPTGTVVRPAELRRFVESVPPHILIA
CCEEEEEECCCHHHHHHHHHHHHHEEEEEEECCCCCCCCEECHHHHHHHHHHCCCEEEEE
IDEAYVEYVREDFTDSLALVREHPNVVVLRTFSKAYGLAGLRVGYAVGDPDVITTLGKVY
ECHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCCEEEEEECCCCHHHHHHHHEE
VPFSASSLAQAAAVASLGAAEELLARTNDVVTERARVTSALREAGYQVPPSQANFVWLPL
ECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
GERSTEFAQASAEARIIVRPFGTDGVRVTIGAPMENDAFLKFSRAWR
CCCCHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA