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The map label for this gene is czcD [H]

Identifier: 169627288

GI number: 169627288

Start: 185913

End: 186887

Strand: Reverse

Name: czcD [H]

Synonym: MAB_0183c

Alternate gene names: 169627288

Gene position: 186887-185913 (Counterclockwise)

Preceding gene: 169627289

Following gene: 169627287

Centisome position: 3.69

GC content: 65.74

Gene sequence:

>975_bases
ATGGCAGCGGACGCACACGAGCACGGCTCCGGGCACTCCCATGGTCACGGCGTGAACGCCGACGCCGATCGGAAATGGCT
GACCATCGCCTTGATCCTGATCGGCGGATTCATGGCCATCGAGGTCGTCATCGGCATCATCGCCCAATCGCTGGCGTTGA
TCTCCGACGCCGGGCATATGCTGACCGACGCGGCATCGATCGTATTGGCGCTCATCGCCATTCGCCTCTCGTCGCGTCCG
GCGCGGGGTAGCTATACGTTCGGCCTCAAGCGCGCCGAGATCCTGTCGGCACAGGCCAACGGCGTGACGCTGTTCCTACT
GGCCGCCTTCTTCATCTACGAGGGCATCCGCCGGCTGATCACTCCCCCGGAGGTCTCAGGCCTGCTGGTGTTCATCACCG
CACTGGCCGGAATCGCCGTCAACGTGGCAGCCACGTGGTGCATCAGCAAGGCCAACCGTTCCAGCCTCAACGTCGAGGGC
GCCTTCCAGCACATCCTCAACGACCTCTACGCATTCATCGCCACCGCCGTCGCCGGCGCCGTGGTGTGGCTCACCGGCTT
CACCCGCGCGGATGCCATCGCCGCACTTGTCGTGGCCGCGCTGATGCTCAAGGCGGGCTGGGGCCTGGTCCGCGAATCGG
GACGGATCTTCTTGGAAGCCGCGCCTGTAGGCCTAGACCCCGGCACCATCGGAACCCAGCTCGCGGCGGTGCACGCGGTG
GCCGAGGTGCACGATCTCCACATCTGGCAGATCACCTCCGGCCAGCCGGCGCTGTCGGCCCACATATTGGTGGCGCCCAA
TGCGGACTGCCACGGAATACGGCGTGAGATCGAGGAGTTGCTCCATACGCAGTACGACATCGACCACACCACCTTGCAGG
TCGACCACGAGGGCACCGAGGCCTCGACGCATTGCTTCGATCCCCACGGAGAGCCGTACCGCGCGGATGGCAGCGCCTTG
CCGGGCAAGGGGTAG

Upstream 100 bases:

>100_bases
AGCATCTGTGATTCACACTTCGGACAGGTCAAGGGCTGAACGTTTGTCATGACAAATGCTAGCATGCATATGTTTGCATG
AATCGTAAGAAGGAGCGGAC

Downstream 100 bases:

>100_bases
GCATCTGATACCAGCAGTAGCGGGCCATGGAGGTCACGATGGGAGAGCCAGCGACTCGCGCCGACGCGTTTCTGCGGGCG
GCCACCATCGCCTTTGTGAT

Product: putative cation transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAADAHEHGSGHSHGHGVNADADRKWLTIALILIGGFMAIEVVIGIIAQSLALISDAGHMLTDAASIVLALIAIRLSSRP
ARGSYTFGLKRAEILSAQANGVTLFLLAAFFIYEGIRRLITPPEVSGLLVFITALAGIAVNVAATWCISKANRSSLNVEG
AFQHILNDLYAFIATAVAGAVVWLTGFTRADAIAALVVAALMLKAGWGLVRESGRIFLEAAPVGLDPGTIGTQLAAVHAV
AEVHDLHIWQITSGQPALSAHILVAPNADCHGIRREIEELLHTQYDIDHTTLQVDHEGTEASTHCFDPHGEPYRADGSAL
PGKG

Sequences:

>Translated_324_residues
MAADAHEHGSGHSHGHGVNADADRKWLTIALILIGGFMAIEVVIGIIAQSLALISDAGHMLTDAASIVLALIAIRLSSRP
ARGSYTFGLKRAEILSAQANGVTLFLLAAFFIYEGIRRLITPPEVSGLLVFITALAGIAVNVAATWCISKANRSSLNVEG
AFQHILNDLYAFIATAVAGAVVWLTGFTRADAIAALVVAALMLKAGWGLVRESGRIFLEAAPVGLDPGTIGTQLAAVHAV
AEVHDLHIWQITSGQPALSAHILVAPNADCHGIRREIEELLHTQYDIDHTTLQVDHEGTEASTHCFDPHGEPYRADGSAL
PGKG
>Mature_323_residues
AADAHEHGSGHSHGHGVNADADRKWLTIALILIGGFMAIEVVIGIIAQSLALISDAGHMLTDAASIVLALIAIRLSSRPA
RGSYTFGLKRAEILSAQANGVTLFLLAAFFIYEGIRRLITPPEVSGLLVFITALAGIAVNVAATWCISKANRSSLNVEGA
FQHILNDLYAFIATAVAGAVVWLTGFTRADAIAALVVAALMLKAGWGLVRESGRIFLEAAPVGLDPGTIGTQLAAVHAVA
EVHDLHIWQITSGQPALSAHILVAPNADCHGIRREIEELLHTQYDIDHTTLQVDHEGTEASTHCFDPHGEPYRADGSALP
GKG

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=304, Percent_Identity=29.6052631578947, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI21359890, Length=308, Percent_Identity=30.5194805194805, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI289803013, Length=316, Percent_Identity=29.746835443038, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI289803009, Length=316, Percent_Identity=29.746835443038, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI289803007, Length=316, Percent_Identity=29.746835443038, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI289803003, Length=316, Percent_Identity=29.746835443038, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI64762489, Length=316, Percent_Identity=29.746835443038, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI21361112, Length=315, Percent_Identity=27.3015873015873, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI20070323, Length=318, Percent_Identity=23.2704402515723, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=25.462962962963, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI222080086, Length=123, Percent_Identity=31.7073170731707, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40255009, Length=123, Percent_Identity=31.7073170731707, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI52351208, Length=118, Percent_Identity=37.2881355932203, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI52352803, Length=122, Percent_Identity=39.344262295082, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786966, Length=279, Percent_Identity=33.6917562724014, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI193210990, Length=322, Percent_Identity=28.8819875776398, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17555794, Length=324, Percent_Identity=28.3950617283951, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17555796, Length=291, Percent_Identity=28.8659793814433, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32564488, Length=305, Percent_Identity=24.2622950819672, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324892, Length=116, Percent_Identity=39.6551724137931, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=137, Percent_Identity=37.2262773722628, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583858, Length=371, Percent_Identity=25.6064690026954, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24584409, Length=141, Percent_Identity=38.2978723404255, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28574430, Length=132, Percent_Identity=37.8787878787879, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645863, Length=114, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585900, Length=144, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585898, Length=144, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585896, Length=144, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921672, Length=144, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34167; Mature: 34035

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADAHEHGSGHSHGHGVNADADRKWLTIALILIGGFMAIEVVIGIIAQSLALISDAGHM
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LTDAASIVLALIAIRLSSRPARGSYTFGLKRAEILSAQANGVTLFLLAAFFIYEGIRRLI
HHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
TPPEVSGLLVFITALAGIAVNVAATWCISKANRSSLNVEGAFQHILNDLYAFIATAVAGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVWLTGFTRADAIAALVVAALMLKAGWGLVRESGRIFLEAAPVGLDPGTIGTQLAAVHAV
HHHHHCCHHHHHHHHHHHHHHHHHHCCHHEECCCEEEEEECCCCCCCCCHHHHHHHHHHH
AEVHDLHIWQITSGQPALSAHILVAPNADCHGIRREIEELLHTQYDIDHTTLQVDHEGTE
HHHHHEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
ASTHCFDPHGEPYRADGSALPGKG
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AADAHEHGSGHSHGHGVNADADRKWLTIALILIGGFMAIEVVIGIIAQSLALISDAGHM
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LTDAASIVLALIAIRLSSRPARGSYTFGLKRAEILSAQANGVTLFLLAAFFIYEGIRRLI
HHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
TPPEVSGLLVFITALAGIAVNVAATWCISKANRSSLNVEGAFQHILNDLYAFIATAVAGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVWLTGFTRADAIAALVVAALMLKAGWGLVRESGRIFLEAAPVGLDPGTIGTQLAAVHAV
HHHHHCCHHHHHHHHHHHHHHHHHHCCHHEECCCEEEEEECCCCCCCCCHHHHHHHHHHH
AEVHDLHIWQITSGQPALSAHILVAPNADCHGIRREIEELLHTQYDIDHTTLQVDHEGTE
HHHHHEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
ASTHCFDPHGEPYRADGSALPGKG
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]