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The map label for this gene is ddn [H]

Identifier: 169627260

GI number: 169627260

Start: 151479

End: 151937

Strand: Direct

Name: ddn [H]

Synonym: MAB_0155

Alternate gene names: 169627260

Gene position: 151479-151937 (Clockwise)

Preceding gene: 169627259

Following gene: 169627262

Centisome position: 2.99

GC content: 61.0

Gene sequence:

>459_bases
ATGACCGAAGGCGTGACCTCGGATACTTACCGCGAACTTTCCGAAAGCGGTGTGCAGAAACACAATAACCGGATGATACG
GCTACTCCGGGAGAACGGCGGCAAGCTACCCGGTGTGCCCGACGACGAGATGCCGGTGCTGATTGTGACCATCACCGGCG
CGAAGTCGGGGATCCAGCGGCTGACACCCTTGGGGTACTTCGAACATCGGGGCCGTCGCTTCGTCGTGGGATCCAACGGG
GGACAGGAACGGCCGCCGTCGTGGATCTTCAACGTGCGCGCCAATCCAGAGGTGACCGTCGAGGTGGTGCCTAACGTCTA
CGCCGCCGTGGCGCGTGAACTGAATTCGGAAGAGCGCCACAGGATGTTCCAGGCACTCGCGGCCAAGTACGCATTCTTCG
GCGACTACCAATCGCGTATCACCAGGGTGATCCCGATGTTCGAACTGGTGCCGTGCTAG

Upstream 100 bases:

>100_bases
CCGAGTCCGATGCGGCTTCCGAGTTGCGCCAGCGGGTACGTACCGTCCGCTAGGCGGGATATACGGGTTCGGCCCGCTGA
GTTCGCGCTAGCGTCGGGGC

Downstream 100 bases:

>100_bases
CCCAGCTTTCTGGACCGCAGCTCATGGCCCTTGGAGGTCAGACAGCGCCCATTCTCCAGGTTCCACTCCCAACCGTGCAG
ATTGCAGGTGAGATTTTTCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTEGVTSDTYRELSESGVQKHNNRMIRLLRENGGKLPGVPDDEMPVLIVTITGAKSGIQRLTPLGYFEHRGRRFVVGSNG
GQERPPSWIFNVRANPEVTVEVVPNVYAAVARELNSEERHRMFQALAAKYAFFGDYQSRITRVIPMFELVPC

Sequences:

>Translated_152_residues
MTEGVTSDTYRELSESGVQKHNNRMIRLLRENGGKLPGVPDDEMPVLIVTITGAKSGIQRLTPLGYFEHRGRRFVVGSNG
GQERPPSWIFNVRANPEVTVEVVPNVYAAVARELNSEERHRMFQALAAKYAFFGDYQSRITRVIPMFELVPC
>Mature_151_residues
TEGVTSDTYRELSESGVQKHNNRMIRLLRENGGKLPGVPDDEMPVLIVTITGAKSGIQRLTPLGYFEHRGRRFVVGSNGG
QERPPSWIFNVRANPEVTVEVVPNVYAAVARELNSEERHRMFQALAAKYAFFGDYQSRITRVIPMFELVPC

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 17137; Mature: 17006

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEGVTSDTYRELSESGVQKHNNRMIRLLRENGGKLPGVPDDEMPVLIVTITGAKSGIQR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHH
LTPLGYFEHRGRRFVVGSNGGQERPPSWIFNVRANPEVTVEVVPNVYAAVARELNSEERH
CCCCCHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHCCCHHHH
RMFQALAAKYAFFGDYQSRITRVIPMFELVPC
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEGVTSDTYRELSESGVQKHNNRMIRLLRENGGKLPGVPDDEMPVLIVTITGAKSGIQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHH
LTPLGYFEHRGRRFVVGSNGGQERPPSWIFNVRANPEVTVEVVPNVYAAVARELNSEERH
CCCCCHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHCCCHHHH
RMFQALAAKYAFFGDYQSRITRVIPMFELVPC
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]