Click here to switch to the map view.

The map label for this gene is ethA [H]

Identifier: 169627208

GI number: 169627208

Start: 103872

End: 105362

Strand: Direct

Name: ethA [H]

Synonym: MAB_0103

Alternate gene names: 169627208

Gene position: 103872-105362 (Clockwise)

Preceding gene: 169627207

Following gene: 169627209

Centisome position: 2.05

GC content: 61.17

Gene sequence:

>1491_bases
ATGTCCGAACACTTTGACGTGCTCATTGTCGGTGCAGGTATCTCCGGGATCAGTGCCGCGTGGCATATCCAGGATCGCTG
CCCGACCAAGACCTACGCGGTGCTTGAAGCCCGCGACGACATGGGCGGCACCTGGAACCTCTTCAAGTACCCGGGTATTC
GCTCCGACTCGGACATGTACACCTTGGGCTTCCGGTTCTCGCCGTGGAACGACAGCAGGACCCTGGCCGATGGTCCGTCG
ATCCTGGACTACGTGCACAAGACGGCGGCCAACGCCGGTATTGACGGGCACGTGCGGTACCGGCAGAAGGTTGTCGGCGC
TGCCTGGAACACCGAAACCCAGCAGTGGACCGTTGAGGTGGATCACGATGGCAAGACCATCGAATACACCTGTTCCTTCC
TGTTCTGCTGCAGTGGGTACTACGACTACGACCAGGGCTACTCTCCGGAGTTCCCCGGGGTGGCCGACTTCAAAGGCACC
GTGGTGCACCCGCAGCACTGGCCCGAAGACCTGGACTACAAGGGCAAGAAGGTGGTCGTGATCGGCTCCGGCGCCACCGC
CGTGACGCTGGTTCCGGCGATGGCGCCCGATACCGGCCACATCACCATGCTGCAGCGTTCGCCCACCTACATCATGTCGC
TGCCCAATGAGAACCCCATCATCAATGGCCTGCGAAAGATTCTGCCGCCCAAGGTGGCTTACCCGATTGCCCGCTGGATC
AATATCGGGCAGCTGATCTTCAGCTACCAAGCCAGCCGCAAGTTCCCGCGCGCCGCACGGCGAATCATCATGCAGCAGGC
CAAGCTTCAGCTGCCCAAGGGGTTCGACTACAAGACGCACTTCGGTCCCAAGTACAACCCCTGGGACGAGCGTTTGTGCG
TGGTGCCCAACGGCGACCTGTACAAGGCCATCCGTAAGGGCAAGGCCGATATCGTCACCGATCACATCGAGACGTTCGAC
GAGACGGGTATCAAGCTGAAGTCGGGCAAGCACCTTGACGCCGATATCATCATCACAGCAACGGGTTTGAACCTGAAGTT
CTTCAGCGGTGTAATTCCGACGGTGGATGGCGTGCCTGTGGATCTGCCCGCGCAGACCGTCTACAAGGGTGCGATGCTCA
CCGGCATCCCCAACATGGCGTTCACCATCGGCTACACCAACGCCTCCTGGACGCTCAAGGCCGACCTGGTGTCCGAGTAC
GTGAGCCGGCTGCTGAACTACATGGACGAGAACGGTTACGTCACAGCGGTTCCCGAGCTCGCCGACGAGACACTGGAGAA
GCAGCCGTTCATGGACTTCACCCCCGGCTACGTGTTGCGCGCGCTGGATGAGTTGCCCAAGCAGGGAAACAAGCACCCCT
GGCGTCTGAAGCAGAACTACGCCTACGACATCGGGATGATGCGGCGCAGCCGGGTCACCGAGGGTATGCGGTTCGGGCGG
AAGAAGACGGCGGCGGCGCCGGCATCTGAATCGGTGGCCGTCAACAGCTAG

Upstream 100 bases:

>100_bases
TGACCAGTGGCAACACGCCCAGGTCTTTACACAGTGTGATCGGGATCGCAAGGGTCTAACTTTACTTTTCTCGCTGATCC
GTAAGCGGTAGCATCGCGGC

Downstream 100 bases:

>100_bases
GTGACTGAACTCCACGAAGAAATTCGTGACGGGGTAGCGGTTCTCACGCTGCACGGACCGTCGACGCGGAACTCCTTCAC
GGTCGAGCTGGGTCGTCAAC

Product: monooxygenase EthA

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSEHFDVLIVGAGISGISAAWHIQDRCPTKTYAVLEARDDMGGTWNLFKYPGIRSDSDMYTLGFRFSPWNDSRTLADGPS
ILDYVHKTAANAGIDGHVRYRQKVVGAAWNTETQQWTVEVDHDGKTIEYTCSFLFCCSGYYDYDQGYSPEFPGVADFKGT
VVHPQHWPEDLDYKGKKVVVIGSGATAVTLVPAMAPDTGHITMLQRSPTYIMSLPNENPIINGLRKILPPKVAYPIARWI
NIGQLIFSYQASRKFPRAARRIIMQQAKLQLPKGFDYKTHFGPKYNPWDERLCVVPNGDLYKAIRKGKADIVTDHIETFD
ETGIKLKSGKHLDADIIITATGLNLKFFSGVIPTVDGVPVDLPAQTVYKGAMLTGIPNMAFTIGYTNASWTLKADLVSEY
VSRLLNYMDENGYVTAVPELADETLEKQPFMDFTPGYVLRALDELPKQGNKHPWRLKQNYAYDIGMMRRSRVTEGMRFGR
KKTAAAPASESVAVNS

Sequences:

>Translated_496_residues
MSEHFDVLIVGAGISGISAAWHIQDRCPTKTYAVLEARDDMGGTWNLFKYPGIRSDSDMYTLGFRFSPWNDSRTLADGPS
ILDYVHKTAANAGIDGHVRYRQKVVGAAWNTETQQWTVEVDHDGKTIEYTCSFLFCCSGYYDYDQGYSPEFPGVADFKGT
VVHPQHWPEDLDYKGKKVVVIGSGATAVTLVPAMAPDTGHITMLQRSPTYIMSLPNENPIINGLRKILPPKVAYPIARWI
NIGQLIFSYQASRKFPRAARRIIMQQAKLQLPKGFDYKTHFGPKYNPWDERLCVVPNGDLYKAIRKGKADIVTDHIETFD
ETGIKLKSGKHLDADIIITATGLNLKFFSGVIPTVDGVPVDLPAQTVYKGAMLTGIPNMAFTIGYTNASWTLKADLVSEY
VSRLLNYMDENGYVTAVPELADETLEKQPFMDFTPGYVLRALDELPKQGNKHPWRLKQNYAYDIGMMRRSRVTEGMRFGR
KKTAAAPASESVAVNS
>Mature_495_residues
SEHFDVLIVGAGISGISAAWHIQDRCPTKTYAVLEARDDMGGTWNLFKYPGIRSDSDMYTLGFRFSPWNDSRTLADGPSI
LDYVHKTAANAGIDGHVRYRQKVVGAAWNTETQQWTVEVDHDGKTIEYTCSFLFCCSGYYDYDQGYSPEFPGVADFKGTV
VHPQHWPEDLDYKGKKVVVIGSGATAVTLVPAMAPDTGHITMLQRSPTYIMSLPNENPIINGLRKILPPKVAYPIARWIN
IGQLIFSYQASRKFPRAARRIIMQQAKLQLPKGFDYKTHFGPKYNPWDERLCVVPNGDLYKAIRKGKADIVTDHIETFDE
TGIKLKSGKHLDADIIITATGLNLKFFSGVIPTVDGVPVDLPAQTVYKGAMLTGIPNMAFTIGYTNASWTLKADLVSEYV
SRLLNYMDENGYVTAVPELADETLEKQPFMDFTPGYVLRALDELPKQGNKHPWRLKQNYAYDIGMMRRSRVTEGMRFGRK
KTAAAPASESVAVNS

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503759, Length=226, Percent_Identity=23.8938053097345, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI50541965, Length=259, Percent_Identity=21.2355212355212, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI50541961, Length=259, Percent_Identity=21.2355212355212, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17541300, Length=227, Percent_Identity=24.6696035242291, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55423; Mature: 55292

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHFDVLIVGAGISGISAAWHIQDRCPTKTYAVLEARDDMGGTWNLFKYPGIRSDSDMY
CCCCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCEE
TLGFRFSPWNDSRTLADGPSILDYVHKTAANAGIDGHVRYRQKVVGAAWNTETQQWTVEV
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEE
DHDGKTIEYTCSFLFCCSGYYDYDQGYSPEFPGVADFKGTVVHPQHWPEDLDYKGKKVVV
CCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEE
IGSGATAVTLVPAMAPDTGHITMLQRSPTYIMSLPNENPIINGLRKILPPKVAYPIARWI
EECCCCEEEEEEECCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
NIGQLIFSYQASRKFPRAARRIIMQQAKLQLPKGFDYKTHFGPKYNPWDERLCVVPNGDL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCHH
YKAIRKGKADIVTDHIETFDETGIKLKSGKHLDADIIITATGLNLKFFSGVIPTVDGVPV
HHHHHCCCCCEEHHHHHHHHHCCEEEECCCCCCCEEEEEEECCCCHHHCCCCCCCCCCCC
DLPAQTVYKGAMLTGIPNMAFTIGYTNASWTLKADLVSEYVSRLLNYMDENGYVTAVPEL
CCCHHHHHCCHHEECCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCEEEECHHH
ADETLEKQPFMDFTPGYVLRALDELPKQGNKHPWRLKQNYAYDIGMMRRSRVTEGMRFGR
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCEEHHHHHHHHHHHHHHHCCC
KKTAAAPASESVAVNS
HHHCCCCCCCCEECCC
>Mature Secondary Structure 
SEHFDVLIVGAGISGISAAWHIQDRCPTKTYAVLEARDDMGGTWNLFKYPGIRSDSDMY
CCCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCEE
TLGFRFSPWNDSRTLADGPSILDYVHKTAANAGIDGHVRYRQKVVGAAWNTETQQWTVEV
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEE
DHDGKTIEYTCSFLFCCSGYYDYDQGYSPEFPGVADFKGTVVHPQHWPEDLDYKGKKVVV
CCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEE
IGSGATAVTLVPAMAPDTGHITMLQRSPTYIMSLPNENPIINGLRKILPPKVAYPIARWI
EECCCCEEEEEEECCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
NIGQLIFSYQASRKFPRAARRIIMQQAKLQLPKGFDYKTHFGPKYNPWDERLCVVPNGDL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCHH
YKAIRKGKADIVTDHIETFDETGIKLKSGKHLDADIIITATGLNLKFFSGVIPTVDGVPV
HHHHHCCCCCEEHHHHHHHHHCCEEEECCCCCCCEEEEEEECCCCHHHCCCCCCCCCCCC
DLPAQTVYKGAMLTGIPNMAFTIGYTNASWTLKADLVSEYVSRLLNYMDENGYVTAVPEL
CCCHHHHHCCHHEECCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCEEEECHHH
ADETLEKQPFMDFTPGYVLRALDELPKQGNKHPWRLKQNYAYDIGMMRRSRVTEGMRFGR
HHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCEEHHHHHHHHHHHHHHHCCC
KKTAAAPASESVAVNS
HHHCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]