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The map label for this gene is tauD [C]

Identifier: 169627191

GI number: 169627191

Start: 82086

End: 83018

Strand: Direct

Name: tauD [C]

Synonym: MAB_0086

Alternate gene names: 169627191

Gene position: 82086-83018 (Clockwise)

Preceding gene: 169627189

Following gene: 169627196

Centisome position: 1.62

GC content: 62.92

Gene sequence:

>933_bases
ATGAGCAGCGATTTGCGGGTCGTGAAGCTGGGCGAGAACATCGGCGCCCGTATCGACGGAGTGCGCCTCGGGGAGGTGGA
CACCGCAACCGCGAGTGCCATCAATGAGGCGATGTTGGAGCACAAGGTGGTCTTCTTTCGTGGGCAACACCATGTGGACG
ACGAGGTGCAATTCGCGTTTGCGAAGAGCATGGGCATACCCACGACTCCGCATCCGACGCTGACTTCGAGTGACGTCAAG
GTGCTCCCGATCGACTCAGAGGAGGGCGGCCGCGCCAACCAGTGGCACACCGACGTGACCTTCGTGGACCGCATCCCCAA
GGCCTCCATTCTGCGTGCGGTCGAGCTGCCGCCCTACGGCGGAACCACCACGTGGACGTCGACGGTCGCCGCGTACCGAC
AGCTGCCCAAGCCGCTGCAGGATCTGGCGGACAACCTGTGGGCCATGCACAACAATCAATTCGATTACACCCAGGTCGAT
CCCGCCAAGGTGGCCGAGTTGTTGGCCAAGGCTGGATCCGGCTCGAAGTACGTCCGTGAGTTTGGTGCGACACATTTCGA
GACGCACCACCCGGTGGTCCGGGTGCACCCGGAGACGGGCGAGAAGGCGCTGCTGCTGGGCAACTTCGTCAAGCGGATCT
TGGATGTGAGTGCCAGCGAGTCGCAGGCGCTGTTCCGGATGTTCCAGGATCGGGTTACCTGGCTGGAGAACACTATTCGA
TGGAGCTGGGAGCTCGGCGACGTGGCCATGTGGGACAACCGCGCTACCCAGCACTACGCCATCTCTGATTACGGTGATCA
GCCACGCCGCATGCACCGCGTCACGCTGGCCGGTGACGTTCCGGTGGGGGTCAATGGTGAGAGCAGCCGGGTGATCGCCG
GCGATGCCAGCGACTACTCGGTGATCGACAATCCGAAGCGGTTGGTGGCCTAG

Upstream 100 bases:

>100_bases
TGGCGTCCGTTGCCTCCGGTGTAGTCATGTGTGTACAGTAGCGGATGACCAAAGTGTAGTCAGTTGACTACACCGGATTA
TCGGACGGAAGGAACGGGTC

Downstream 100 bases:

>100_bases
CGTTGTCGGCGAGCAGACACGTATTGCGCGCCCATCCAGAGGTTGTTGTCATGCGTGTCTGCTCGCGCGTGGGGCGCTAG
GTCTGGCGCTTACCCACGAG

Product: putative taurine dioxygenase

Products: Aminoacetaldehyde; CO2; H+; Sulfite; Succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSSDLRVVKLGENIGARIDGVRLGEVDTATASAINEAMLEHKVVFFRGQHHVDDEVQFAFAKSMGIPTTPHPTLTSSDVK
VLPIDSEEGGRANQWHTDVTFVDRIPKASILRAVELPPYGGTTTWTSTVAAYRQLPKPLQDLADNLWAMHNNQFDYTQVD
PAKVAELLAKAGSGSKYVREFGATHFETHHPVVRVHPETGEKALLLGNFVKRILDVSASESQALFRMFQDRVTWLENTIR
WSWELGDVAMWDNRATQHYAISDYGDQPRRMHRVTLAGDVPVGVNGESSRVIAGDASDYSVIDNPKRLVA

Sequences:

>Translated_310_residues
MSSDLRVVKLGENIGARIDGVRLGEVDTATASAINEAMLEHKVVFFRGQHHVDDEVQFAFAKSMGIPTTPHPTLTSSDVK
VLPIDSEEGGRANQWHTDVTFVDRIPKASILRAVELPPYGGTTTWTSTVAAYRQLPKPLQDLADNLWAMHNNQFDYTQVD
PAKVAELLAKAGSGSKYVREFGATHFETHHPVVRVHPETGEKALLLGNFVKRILDVSASESQALFRMFQDRVTWLENTIR
WSWELGDVAMWDNRATQHYAISDYGDQPRRMHRVTLAGDVPVGVNGESSRVIAGDASDYSVIDNPKRLVA
>Mature_309_residues
SSDLRVVKLGENIGARIDGVRLGEVDTATASAINEAMLEHKVVFFRGQHHVDDEVQFAFAKSMGIPTTPHPTLTSSDVKV
LPIDSEEGGRANQWHTDVTFVDRIPKASILRAVELPPYGGTTTWTSTVAAYRQLPKPLQDLADNLWAMHNNQFDYTQVDP
AKVAELLAKAGSGSKYVREFGATHFETHHPVVRVHPETGEKALLLGNFVKRILDVSASESQALFRMFQDRVTWLENTIRW
SWELGDVAMWDNRATQHYAISDYGDQPRRMHRVTLAGDVPVGVNGESSRVIAGDASDYSVIDNPKRLVA

Specific function: Catalyzes The Conversion Of Taurine And Alpha Ketoglutarate To Sulfite, Aminoacetaldehyde And Succinate. Required For The Utilization Of Taurine (2-Aminoethanesulfonic Acid) As An Alternative Sulfur Source. Pentane-Sulfonic Acid, 3- (N-Morpholino)Propanes

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tfdA dioxygenase family [H]

Homologues:

Organism=Escherichia coli, GI1786565, Length=287, Percent_Identity=37.9790940766551, Blast_Score=168, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6322971, Length=296, Percent_Identity=29.0540540540541, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: 1.14.11.17 [C]

Molecular weight: Translated: 34430; Mature: 34299

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDLRVVKLGENIGARIDGVRLGEVDTATASAINEAMLEHKVVFFRGQHHVDDEVQFAF
CCCCCEEEEECCCCCCEECCEEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHH
AKSMGIPTTPHPTLTSSDVKVLPIDSEEGGRANQWHTDVTFVDRIPKASILRAVELPPYG
HHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCHHHHHHEEECCCCC
GTTTWTSTVAAYRQLPKPLQDLADNLWAMHNNQFDYTQVDPAKVAELLAKAGSGSKYVRE
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHH
FGATHFETHHPVVRVHPETGEKALLLGNFVKRILDVSASESQALFRMFQDRVTWLENTIR
HCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEE
WSWELGDVAMWDNRATQHYAISDYGDQPRRMHRVTLAGDVPVGVNGESSRVIAGDASDYS
EEEEECCEEEECCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCC
VIDNPKRLVA
CCCCCHHHCC
>Mature Secondary Structure 
SSDLRVVKLGENIGARIDGVRLGEVDTATASAINEAMLEHKVVFFRGQHHVDDEVQFAF
CCCCEEEEECCCCCCEECCEEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHH
AKSMGIPTTPHPTLTSSDVKVLPIDSEEGGRANQWHTDVTFVDRIPKASILRAVELPPYG
HHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCHHHHHHEEECCCCC
GTTTWTSTVAAYRQLPKPLQDLADNLWAMHNNQFDYTQVDPAKVAELLAKAGSGSKYVRE
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHH
FGATHFETHHPVVRVHPETGEKALLLGNFVKRILDVSASESQALFRMFQDRVTWLENTIR
HCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEE
WSWELGDVAMWDNRATQHYAISDYGDQPRRMHRVTLAGDVPVGVNGESSRVIAGDASDYS
EEEEECCEEEECCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCC
VIDNPKRLVA
CCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Ascorbate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; O2; Taurine [C]

Specific reaction: 2-Oxoglutarate + O2 + Taurine --> Aminoacetaldehyde + CO2 + H+ + Sulfite + Succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]