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The map label for this gene is cynR [H]

Identifier: 169627160

GI number: 169627160

Start: 49640

End: 50524

Strand: Reverse

Name: cynR [H]

Synonym: MAB_0055c

Alternate gene names: 169627160

Gene position: 50524-49640 (Counterclockwise)

Preceding gene: 169627161

Following gene: 169627159

Centisome position: 1.0

GC content: 65.08

Gene sequence:

>885_bases
ATGGAACTGCGTCATATCCGGTATCTCCTCGCAGTAGCCGATCACGCCAATTTCACCCGCGCGGCCGAGTCATTGCACAT
CTCGCAACCGACGCTGTCCCAGCAGATCAAGCAGCTCGAACGCACGCTTGGAGTGATCCTGCTCGATCGTTCGGGTCGCG
CCGTTCGATTGACCGATGCCGGCGAGGCATACGCCCAGCACGCACGCCTGGCCCTGCGCGATCTGGATGCCGGAGAACGC
GCCGTGCACGATATGCACGATCTGTCGCGCGGGCATCTCCGCATCGCCATGACGCCCACGTTTACCGCCTATTTCATTGG
GCCACTGGTACATCGGTTCCACAGCGCGCATCCAGGTATCACCCTCACGGTGCGTGAGACAACGCAGGACCGCATCGAGG
CCGATCTGCTGGCCGACCGCCTGGATCTGGGTATCGCCTTCGCGGGACCACATCCCGCGGGCATCGACCACTGTGCGCTA
TTCACCGAGACTCTGCGCCTGGTGGTGGGCACCGGACACCGGCTGGCGATGCGACACCGTTCGCTGCCGGTGGCTCAACT
CTCCCGTGAGGCGCTGGGCCTACTCAGCCCGGATTTCGCGACGCGGCAGGACATCGACGCCTATTTCGCCGGCCTCGGGG
TCGCCCCGCACATTGCCGTCGAAGCCAACTCGATCAGTGCCCTGCTGGAGTTCGTCAAGCGAGGATCGCTGGCGACCGTG
CTTCCCGACGCGATCGCACATGAGCATTCCGACCTGCACCTGGTGCCGCTGTCGCCGCCATTACCCATCCGCACCGTGGA
GTTGTTGCGCCGCAGCAGCGCTTATCACTCGGCCGCGGCGCGCGCGTTCACGGAGATGGTCCATGCGGGCGCCCGAGGGC
GCTGA

Upstream 100 bases:

>100_bases
GCCGTGCGCGAGCTCCGGCGACCACGAAAATCTATGGTGTCCAAGACATGCATCTGATCATGACGATTGATGTCGTCTAT
AGCGATCTATAGTGACATCG

Downstream 100 bases:

>100_bases
GCCTCATCAGCTATTCGTTGGACCAATAGAAGTCATTGAATACAAGTATTGGACTCTATAGCACCAGCTAGCCCACTCTG
GACTCAGCGACGGGTACCGG

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MELRHIRYLLAVADHANFTRAAESLHISQPTLSQQIKQLERTLGVILLDRSGRAVRLTDAGEAYAQHARLALRDLDAGER
AVHDMHDLSRGHLRIAMTPTFTAYFIGPLVHRFHSAHPGITLTVRETTQDRIEADLLADRLDLGIAFAGPHPAGIDHCAL
FTETLRLVVGTGHRLAMRHRSLPVAQLSREALGLLSPDFATRQDIDAYFAGLGVAPHIAVEANSISALLEFVKRGSLATV
LPDAIAHEHSDLHLVPLSPPLPIRTVELLRRSSAYHSAAARAFTEMVHAGARGR

Sequences:

>Translated_294_residues
MELRHIRYLLAVADHANFTRAAESLHISQPTLSQQIKQLERTLGVILLDRSGRAVRLTDAGEAYAQHARLALRDLDAGER
AVHDMHDLSRGHLRIAMTPTFTAYFIGPLVHRFHSAHPGITLTVRETTQDRIEADLLADRLDLGIAFAGPHPAGIDHCAL
FTETLRLVVGTGHRLAMRHRSLPVAQLSREALGLLSPDFATRQDIDAYFAGLGVAPHIAVEANSISALLEFVKRGSLATV
LPDAIAHEHSDLHLVPLSPPLPIRTVELLRRSSAYHSAAARAFTEMVHAGARGR
>Mature_294_residues
MELRHIRYLLAVADHANFTRAAESLHISQPTLSQQIKQLERTLGVILLDRSGRAVRLTDAGEAYAQHARLALRDLDAGER
AVHDMHDLSRGHLRIAMTPTFTAYFIGPLVHRFHSAHPGITLTVRETTQDRIEADLLADRLDLGIAFAGPHPAGIDHCAL
FTETLRLVVGTGHRLAMRHRSLPVAQLSREALGLLSPDFATRQDIDAYFAGLGVAPHIAVEANSISALLEFVKRGSLATV
LPDAIAHEHSDLHLVPLSPPLPIRTVELLRRSSAYHSAAARAFTEMVHAGARGR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=283, Percent_Identity=54.416961130742, Blast_Score=300, Evalue=7e-83,
Organism=Escherichia coli, GI1790399, Length=296, Percent_Identity=30.0675675675676, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787879, Length=289, Percent_Identity=29.757785467128, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788887, Length=246, Percent_Identity=32.1138211382114, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI145693105, Length=284, Percent_Identity=27.8169014084507, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=31.5789473684211, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787601, Length=276, Percent_Identity=25, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788748, Length=289, Percent_Identity=29.4117647058824, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI87081904, Length=232, Percent_Identity=31.0344827586207, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789204, Length=292, Percent_Identity=28.0821917808219, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789173, Length=163, Percent_Identity=34.3558282208589, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI2367136, Length=250, Percent_Identity=28.8, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787530, Length=238, Percent_Identity=26.0504201680672, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786401, Length=127, Percent_Identity=33.0708661417323, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790262, Length=226, Percent_Identity=26.5486725663717, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787589, Length=201, Percent_Identity=26.865671641791, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789639, Length=143, Percent_Identity=29.3706293706294, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790208, Length=287, Percent_Identity=26.4808362369338, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI145693193, Length=238, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082132, Length=168, Percent_Identity=27.3809523809524, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32206; Mature: 32206

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHIRYLLAVADHANFTRAAESLHISQPTLSQQIKQLERTLGVILLDRSGRAVRLTDA
CCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEECCCCCEEEEECC
GEAYAQHARLALRDLDAGERAVHDMHDLSRGHLRIAMTPTFTAYFIGPLVHRFHSAHPGI
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCE
TLTVRETTQDRIEADLLADRLDLGIAFAGPHPAGIDHCALFTETLRLVVGTGHRLAMRHR
EEEEECCCHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHC
SLPVAQLSREALGLLSPDFATRQDIDAYFAGLGVAPHIAVEANSISALLEFVKRGSLATV
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCHHH
LPDAIAHEHSDLHLVPLSPPLPIRTVELLRRSSAYHSAAARAFTEMVHAGARGR
CCHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MELRHIRYLLAVADHANFTRAAESLHISQPTLSQQIKQLERTLGVILLDRSGRAVRLTDA
CCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEECCCCCEEEEECC
GEAYAQHARLALRDLDAGERAVHDMHDLSRGHLRIAMTPTFTAYFIGPLVHRFHSAHPGI
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCE
TLTVRETTQDRIEADLLADRLDLGIAFAGPHPAGIDHCALFTETLRLVVGTGHRLAMRHR
EEEEECCCHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHC
SLPVAQLSREALGLLSPDFATRQDIDAYFAGLGVAPHIAVEANSISALLEFVKRGSLATV
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCHHH
LPDAIAHEHSDLHLVPLSPPLPIRTVELLRRSSAYHSAAARAFTEMVHAGARGR
CCHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]