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The map label for this gene is nat [H]

Identifier: 169627121

GI number: 169627121

Start: 13080

End: 13916

Strand: Reverse

Name: nat [H]

Synonym: MAB_0013c

Alternate gene names: 169627121

Gene position: 13916-13080 (Counterclockwise)

Preceding gene: 169627126

Following gene: 169627120

Centisome position: 0.27

GC content: 63.08

Gene sequence:

>837_bases
ATGTGGAACGGCGATGAGCTTCAGCTCGATGAATACCTGGCCTTTATCGGCTTCGACGGCGATCGGTCGCCGACGCTGGA
GACCCTGCGCCGCCTGCAACGCGGCCACGTCTTGAACATCAAGTGGGAGAACCTTGATGCGGTGCTGCATAAGCATGTCG
CACTGGATATCCCGGCCGTTCAGGCCAAGCTGTTGCGGAGCCCGCGCGGCGGCTACTGCTACGAGCACGTCGCCCTCTTT
GGAGCCGTCCTGCAGCGCCTCGGCTTCGACTTCTACGGCATTCAGGGCCGGGTGCAGATGGGCGCCACAACAATTCGCCC
TGCCACCCACGGCATGCTCGTCGTTCGGCTTGCCGCAGAGCAATGGCTGTGCGACGTCGGATTTGGCACCAGCCCCCTGG
CGCCGATCCGCCTCGTCGACGAAGCCGTCGTCGCCGATGAGTCCTGGACCTACCGACTGCGGCGCGGTGAGGTAACCCCA
GGTGCCGACGGATGGACACTCTCCGAAGCCGCAGGAGACGGGTCCGAACCCGGGTGGCTCAGCCGGCATACCTTTGTACT
GGAGCCGCAATACCCGATCGACTACCGAGCCGCGAGCTATTTCGTTGCCTCAAGCCCTCATTCACCTTTCAGCACAAGAG
CTTTCGTACAGCAGATCAGCCCGGACCATGCATACATCTTGGACCACCGGGAACTCCACGAAATCCAGCCCGGGGTGGGG
CGAAAGACCCGGCAGCTGACGCCCGCTGAGGTGCTGGCCACGCTCCGAGAAATATTCGGCATCGAGCTGGGCGCGGATGA
TTCCACTTTGCTGTTGGAGCGGCTGGCCGAGCAGTAG

Upstream 100 bases:

>100_bases
TGCTCCGACGTGACGAACTCCCGATTGGTTCCGTCTTTCTGCCAGATTTGCTTGGCGCCGCTACGGGCATTCCGCGAGTA
ACAAGTACGTTGTCCACACC

Downstream 100 bases:

>100_bases
CCTCCGCACACGACCGAAACCATCGCGTCGAGCTCGCCGGACATCGATCAGCTGCTCGACTCGTGGTGGGTCTCTCCGGG
CCCACGGTGGTGTGCGCTGC

Product: arylamine n-acetyl transferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MWNGDELQLDEYLAFIGFDGDRSPTLETLRRLQRGHVLNIKWENLDAVLHKHVALDIPAVQAKLLRSPRGGYCYEHVALF
GAVLQRLGFDFYGIQGRVQMGATTIRPATHGMLVVRLAAEQWLCDVGFGTSPLAPIRLVDEAVVADESWTYRLRRGEVTP
GADGWTLSEAAGDGSEPGWLSRHTFVLEPQYPIDYRAASYFVASSPHSPFSTRAFVQQISPDHAYILDHRELHEIQPGVG
RKTRQLTPAEVLATLREIFGIELGADDSTLLLERLAEQ

Sequences:

>Translated_278_residues
MWNGDELQLDEYLAFIGFDGDRSPTLETLRRLQRGHVLNIKWENLDAVLHKHVALDIPAVQAKLLRSPRGGYCYEHVALF
GAVLQRLGFDFYGIQGRVQMGATTIRPATHGMLVVRLAAEQWLCDVGFGTSPLAPIRLVDEAVVADESWTYRLRRGEVTP
GADGWTLSEAAGDGSEPGWLSRHTFVLEPQYPIDYRAASYFVASSPHSPFSTRAFVQQISPDHAYILDHRELHEIQPGVG
RKTRQLTPAEVLATLREIFGIELGADDSTLLLERLAEQ
>Mature_278_residues
MWNGDELQLDEYLAFIGFDGDRSPTLETLRRLQRGHVLNIKWENLDAVLHKHVALDIPAVQAKLLRSPRGGYCYEHVALF
GAVLQRLGFDFYGIQGRVQMGATTIRPATHGMLVVRLAAEQWLCDVGFGTSPLAPIRLVDEAVVADESWTYRLRRGEVTP
GADGWTLSEAAGDGSEPGWLSRHTFVLEPQYPIDYRAASYFVASSPHSPFSTRAFVQQISPDHAYILDHRELHEIQPGVG
RKTRQLTPAEVLATLREIFGIELGADDSTLLLERLAEQ

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1787736, Length=264, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 31060; Mature: 31060

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNGDELQLDEYLAFIGFDGDRSPTLETLRRLQRGHVLNIKWENLDAVLHKHVALDIPAV
CCCCCCEEHHHEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCHHH
QAKLLRSPRGGYCYEHVALFGAVLQRLGFDFYGIQGRVQMGATTIRPATHGMLVVRLAAE
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEECCCCEEEECCEEECCCCCCEEEEEEHHH
QWLCDVGFGTSPLAPIRLVDEAVVADESWTYRLRRGEVTPGADGWTLSEAAGDGSEPGWL
HHHEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEHHCCCCCCCCCCC
SRHTFVLEPQYPIDYRAASYFVASSPHSPFSTRAFVQQISPDHAYILDHRELHEIQPGVG
CCCEEEECCCCCCCCCHHEEEEECCCCCCHHHHHHHHHCCCCCEEEECCHHHHHCCCCCC
RKTRQLTPAEVLATLREIFGIELGADDSTLLLERLAEQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MWNGDELQLDEYLAFIGFDGDRSPTLETLRRLQRGHVLNIKWENLDAVLHKHVALDIPAV
CCCCCCEEHHHEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCHHH
QAKLLRSPRGGYCYEHVALFGAVLQRLGFDFYGIQGRVQMGATTIRPATHGMLVVRLAAE
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEECCCCEEEECCEEECCCCCCEEEEEEHHH
QWLCDVGFGTSPLAPIRLVDEAVVADESWTYRLRRGEVTPGADGWTLSEAAGDGSEPGWL
HHHEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEHHCCCCCCCCCCC
SRHTFVLEPQYPIDYRAASYFVASSPHSPFSTRAFVQQISPDHAYILDHRELHEIQPGVG
CCCEEEECCCCCCCCCHHEEEEECCCCCCHHHHHHHHHCCCCCEEEECCHHHHHCCCCCC
RKTRQLTPAEVLATLREIFGIELGADDSTLLLERLAEQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]