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The map label for this gene is idnD [H]

Identifier: 16767729

GI number: 16767729

Start: 4727963

End: 4728994

Strand: Reverse

Name: idnD [H]

Synonym: STM4484

Alternate gene names: 16767729

Gene position: 4728994-4727963 (Counterclockwise)

Preceding gene: 16767731

Following gene: 16767728

Centisome position: 97.36

GC content: 50.19

Gene sequence:

>1032_bases
ATGGAAGTAAAAACTCAATCCTGCGTTGTTGCGGGTAAGCGTGCTGTTGCCGTTACGGAACAAAATATTGAATGGAATAA
TAAAGGAACTCTCGTACAAATTACCCGTGGCGGCATTTGTGGGTCTGACTTACATTATTATCAGGAAGGCAAAGTCGGCA
ATTTTACAGTAAAAGCGCCAATGATTTTAGGTCATGAAGTGATTGGCAAAATCGTTCATAGCGACTCAGATTTATTACGT
GAAGGACAACCGGTAGCAATTAATCCATCGGAGCCTTGCGGTCATTGCAAATACTGTCTGCAGCATGAAGAAAACCACTG
TACTGAAATGCGTTTCTTTGGCAGCGCCATGTATTTTCCGCATGTCGATGGCGGTTTTACCCGATTTAAAGCTGTCGATA
CCGCTCAGTGCATTCCCTGGCCGGAACAGGCGGACGAAAAAGCCATGGCCTTTGCCGAGCCGCTGGCGGTTGCCATTCAT
GCAGCTCATGAGGCGGGCGATCTGCAGGGCAAACGCATCTTTATCTCCGGCGTTGGCCCTATCGGCTGCCTGATTGTTAG
CGCGGTAAAAACGCTGGGCGCGGCGGAAGTGGTATGTGCCGATATCAGTACCCGTTCTCTCTCGCTGGCCCGGCAGATGG
GCGCGGATACGCTGGTGAACCCACAGCATGATTCTCTCGATGACTGGAAAGCAGAAAAAGGGTATTTCGATATCAGTTTT
GAAGTCTCTGGGCATCCTTCCTCTATCTCAACGTGTCTGGAAGTCACACGGGCCAAAGGCGTGATGGTGCAGGTTGGCAT
GGGCGGCGCAGTTCCCAACTTCCCGATGATGATGGTAATAAGCAAAGAGATCTCCCTGAAAGGCTCTTTCCGCTTTACTA
CCGAATTTAATACTGCGGTTTCCTGGCTTGCCAACCGCGTTATCAATCCGCTGCCGTTACTGAGCGCGGAATATCCATTT
ACCGACCTGGAAGCGGCGCTGATCTTTGCCGGAGACAAAACACAGGCGGCAAAAGTTCAGCTCGTTTTCTGA

Upstream 100 bases:

>100_bases
TTGTAGTGTAACAATTTTCCAGCGTGACATAAGTCACAAATAGTGACAAATAAAACCGCTTAAATGCGTTCAGGGTAACT
ACCTGACCAGTGAGGAATTT

Downstream 100 bases:

>100_bases
GAAAGTAAAATAAGGGACACTATCATGAACGATCTTTTTTCACTGGCAGGTAAAAATATCCTTATCACCGGAGCCGCTCA
GGGAATTGGTTATTTGCTGG

Product: L-idonate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAPMILGHEVIGKIVHSDSDLLR
EGQPVAINPSEPCGHCKYCLQHEENHCTEMRFFGSAMYFPHVDGGFTRFKAVDTAQCIPWPEQADEKAMAFAEPLAVAIH
AAHEAGDLQGKRIFISGVGPIGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDDWKAEKGYFDISF
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAVSWLANRVINPLPLLSAEYPF
TDLEAALIFAGDKTQAAKVQLVF

Sequences:

>Translated_343_residues
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAPMILGHEVIGKIVHSDSDLLR
EGQPVAINPSEPCGHCKYCLQHEENHCTEMRFFGSAMYFPHVDGGFTRFKAVDTAQCIPWPEQADEKAMAFAEPLAVAIH
AAHEAGDLQGKRIFISGVGPIGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDDWKAEKGYFDISF
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAVSWLANRVINPLPLLSAEYPF
TDLEAALIFAGDKTQAAKVQLVF
>Mature_343_residues
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAPMILGHEVIGKIVHSDSDLLR
EGQPVAINPSEPCGHCKYCLQHEENHCTEMRFFGSAMYFPHVDGGFTRFKAVDTAQCIPWPEQADEKAMAFAEPLAVAIH
AAHEAGDLQGKRIFISGVGPIGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDDWKAEKGYFDISF
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAVSWLANRVINPLPLLSAEYPF
TDLEAALIFAGDKTQAAKVQLVF

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=304, Percent_Identity=33.5526315789474, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1790718, Length=343, Percent_Identity=82.798833819242, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI1788073, Length=307, Percent_Identity=28.6644951140065, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1787863, Length=344, Percent_Identity=26.7441860465116, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790045, Length=312, Percent_Identity=26.9230769230769, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788407, Length=333, Percent_Identity=28.2282282282282, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI226510992, Length=303, Percent_Identity=30.3630363036304, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786825, Length=217, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788075, Length=336, Percent_Identity=24.702380952381, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082125, Length=272, Percent_Identity=26.8382352941176, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=25.748502994012, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=321, Percent_Identity=34.8909657320872, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17562878, Length=324, Percent_Identity=33.9506172839506, Blast_Score=167, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6322619, Length=306, Percent_Identity=32.0261437908497, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319955, Length=306, Percent_Identity=32.0261437908497, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323099, Length=335, Percent_Identity=30.4477611940298, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319258, Length=311, Percent_Identity=27.3311897106109, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=295, Percent_Identity=24.7457627118644, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=271, Percent_Identity=25.830258302583, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17737897, Length=307, Percent_Identity=30.9446254071661, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI17137530, Length=312, Percent_Identity=30.1282051282051, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 37168; Mature: 37168

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAP
CCCCCCHHEEECCEEEEEEECCCEECCCCCEEEEECCCCCCCCCCEEECCCCCCEEEECC
MILGHEVIGKIVHSDSDLLREGQPVAINPSEPCGHCKYCLQHEENHCTEMRFFGSAMYFP
HHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCCCHHHHHHHCCCCCHHHHEEECCEEECC
HVDGGFTRFKAVDTAQCIPWPEQADEKAMAFAEPLAVAIHAAHEAGDLQGKRIFISGVGP
CCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHEEEEEHHCCCCCCCCEEEEECCCH
IGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDDWKAEKGYFDISF
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEE
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAV
EECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECEEECCCEEEEEEHHHHH
SWLANRVINPLPLLSAEYPFTDLEAALIFAGDKTQAAKVQLVF
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MEVKTQSCVVAGKRAVAVTEQNIEWNNKGTLVQITRGGICGSDLHYYQEGKVGNFTVKAP
CCCCCCHHEEECCEEEEEEECCCEECCCCCEEEEECCCCCCCCCCEEECCCCCCEEEECC
MILGHEVIGKIVHSDSDLLREGQPVAINPSEPCGHCKYCLQHEENHCTEMRFFGSAMYFP
HHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCCCHHHHHHHCCCCCHHHHEEECCEEECC
HVDGGFTRFKAVDTAQCIPWPEQADEKAMAFAEPLAVAIHAAHEAGDLQGKRIFISGVGP
CCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHEEEEEHHCCCCCCCCEEEEECCCH
IGCLIVSAVKTLGAAEVVCADISTRSLSLARQMGADTLVNPQHDSLDDWKAEKGYFDISF
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEE
EVSGHPSSISTCLEVTRAKGVMVQVGMGGAVPNFPMMMVISKEISLKGSFRFTTEFNTAV
EECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECEEECCCEEEEEEHHHHH
SWLANRVINPLPLLSAEYPFTDLEAALIFAGDKTQAAKVQLVF
HHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]