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The map label for this gene is yjcC [H]

Identifier: 16767514

GI number: 16767514

Start: 4502381

End: 4503982

Strand: Direct

Name: yjcC [H]

Synonym: STM4264

Alternate gene names: 16767514

Gene position: 4502381-4503982 (Clockwise)

Preceding gene: 16767512

Following gene: 16767516

Centisome position: 92.69

GC content: 47.5

Gene sequence:

>1602_bases
ATGAGTCAAAGCACACGACGCAAGGTGTTGAGATTTCTCGGAACGATCATTGTGGTGTTACTTCCTATATTGCTGGCGAT
CTGGTTTGCTCATATCCGGGCAGTCTCTGAAACCAGAAATCAGTTACATTCATTTGCGCAGTTGGTATTAGATAAAACGG
AGCGGGTTATCCTGCAAGCAGATTTAGCCCGCGATGCCGCTGAACAATATCAGGGGCAAGCCTGTACGCCAGCCCATCAA
CAGCGAATGCTGAATATTATCCGCGGTCGTTTGTACATTAATGAGTTGATTTATGCTAAGGGCCAGCGTTTTCTATGCTC
TACGGTTATGACGCCAACAAGTCCTTATTTTATTCCCCGCGCTGACTATAAACGAAAGCCTGACATCGCTATTTATTACT
ATCGTGATACGCCTTTTTTCAACGGTTATAAAATGACATATATGCAGCGGGGAAACTATGTCGCGGTTATCAATCCCTTA
TCTTATAGCGAGGTGATGTCAGACGATCCGGCGTTGGCCTGGGGAATGTATGATACGGTGACCAACACCTTTTTCTCCCT
GAGTGAACAGGCGCAGGCTGATCAGCTATTACCTTTGGTACGACGGAGTGAACCTGTGTTCCAACAGGGTGAGCGTTTTT
ATACTCTGGTTAAATCAGCAAAACGACCGGTTGCCGCGATTGTGTCAACCTCAAAGCAACGCTTTTACCAGAACCTCTTT
CATCAGCTTACGTTAACGCTACCGTTAGGGATCATCTGTAGCATTATCATCTTATTTATGTGGTCACGATCCCGGCAGGC
ATATTACTCACCGCGTCGATTGCTGCAACGGGCCATTACCAGGCACCAGCTTTGCCTTCATTATCAGCCGATCATTGATA
TCCGAAACGGGACATGTGTAGGTGCCGAAGCGCTATTGCGTTGGCCGGGCTATCACGGTCCGGTGATGAGCCCGTGCGAA
TTTATTCCGCTGGCGGAAAAAGAGGGGATGATTGAGCAGATCACCGATTATGTCGTCGAAGAGGTATTTAATGATTTAGG
TGGTTTTCTGGCCGCGCACCCGCATCTTTATGTCTCTATCAATCTCGCTGCCGCCGATTTTCTCTCTTCCCGACTAATTG
TGATGATTCATGAAAAAACGCGTCAGCATTCAGTGCTTGCGCAACAGATAAAGGTTGAAGTGACTGAGCGCGGATTTATT
GATGTGCCTAAAATGACGCCGATTATTCAGGCGTTTCGCCAGGCGGGATACGAGGTGGCAATTGATGACTTTGGTACCGG
CTATTCGAACTTGCATAACCTGTACTCATTAAATATCGACCTTTTAAAAATTGATAAATCTTTTGTCGACACGCTAACCA
CTAATAGCGCCAGCCATTTGATTGTGGAACATATTATTGAAATGGCGCAAAGTTTGCGGCTAAAAATCATTGCTGAGGGG
GTTGAAACGGCTGAACAGGTTAGCTGGTTGCTAAAACGCGGCGTTCAGTATTGTCAGGGATGGCACTTTGCGAAGGCGTT
ACCACCGCAGGAATTCATCGCCTGGCTACAACAAACGCCCGCGCCTCTGACGATACGCGGGCAGACGCCCTACAGGCGGT
GA

Upstream 100 bases:

>100_bases
GTTGCTAATATTGATAAATTCATGCACCGTAAACCTCCATTTGGTTCACGTCTTATTTTGCCAACAATAGTCACAAATAA
TGCAGGGAAATAGGCTGAAA

Downstream 100 bases:

>100_bases
CGGTAATCGCTGGGAGTGCGATCGAACTCGCGGCGGAATACACGCGAGAAGGTTTGCTGCGATACATAGCCCAGGTCCAT
CGCGATATCAAAAATCGGGC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MSQSTRRKVLRFLGTIIVVLLPILLAIWFAHIRAVSETRNQLHSFAQLVLDKTERVILQADLARDAAEQYQGQACTPAHQ
QRMLNIIRGRLYINELIYAKGQRFLCSTVMTPTSPYFIPRADYKRKPDIAIYYYRDTPFFNGYKMTYMQRGNYVAVINPL
SYSEVMSDDPALAWGMYDTVTNTFFSLSEQAQADQLLPLVRRSEPVFQQGERFYTLVKSAKRPVAAIVSTSKQRFYQNLF
HQLTLTLPLGIICSIIILFMWSRSRQAYYSPRRLLQRAITRHQLCLHYQPIIDIRNGTCVGAEALLRWPGYHGPVMSPCE
FIPLAEKEGMIEQITDYVVEEVFNDLGGFLAAHPHLYVSINLAAADFLSSRLIVMIHEKTRQHSVLAQQIKVEVTERGFI
DVPKMTPIIQAFRQAGYEVAIDDFGTGYSNLHNLYSLNIDLLKIDKSFVDTLTTNSASHLIVEHIIEMAQSLRLKIIAEG
VETAEQVSWLLKRGVQYCQGWHFAKALPPQEFIAWLQQTPAPLTIRGQTPYRR

Sequences:

>Translated_533_residues
MSQSTRRKVLRFLGTIIVVLLPILLAIWFAHIRAVSETRNQLHSFAQLVLDKTERVILQADLARDAAEQYQGQACTPAHQ
QRMLNIIRGRLYINELIYAKGQRFLCSTVMTPTSPYFIPRADYKRKPDIAIYYYRDTPFFNGYKMTYMQRGNYVAVINPL
SYSEVMSDDPALAWGMYDTVTNTFFSLSEQAQADQLLPLVRRSEPVFQQGERFYTLVKSAKRPVAAIVSTSKQRFYQNLF
HQLTLTLPLGIICSIIILFMWSRSRQAYYSPRRLLQRAITRHQLCLHYQPIIDIRNGTCVGAEALLRWPGYHGPVMSPCE
FIPLAEKEGMIEQITDYVVEEVFNDLGGFLAAHPHLYVSINLAAADFLSSRLIVMIHEKTRQHSVLAQQIKVEVTERGFI
DVPKMTPIIQAFRQAGYEVAIDDFGTGYSNLHNLYSLNIDLLKIDKSFVDTLTTNSASHLIVEHIIEMAQSLRLKIIAEG
VETAEQVSWLLKRGVQYCQGWHFAKALPPQEFIAWLQQTPAPLTIRGQTPYRR
>Mature_532_residues
SQSTRRKVLRFLGTIIVVLLPILLAIWFAHIRAVSETRNQLHSFAQLVLDKTERVILQADLARDAAEQYQGQACTPAHQQ
RMLNIIRGRLYINELIYAKGQRFLCSTVMTPTSPYFIPRADYKRKPDIAIYYYRDTPFFNGYKMTYMQRGNYVAVINPLS
YSEVMSDDPALAWGMYDTVTNTFFSLSEQAQADQLLPLVRRSEPVFQQGERFYTLVKSAKRPVAAIVSTSKQRFYQNLFH
QLTLTLPLGIICSIIILFMWSRSRQAYYSPRRLLQRAITRHQLCLHYQPIIDIRNGTCVGAEALLRWPGYHGPVMSPCEF
IPLAEKEGMIEQITDYVVEEVFNDLGGFLAAHPHLYVSINLAAADFLSSRLIVMIHEKTRQHSVLAQQIKVEVTERGFID
VPKMTPIIQAFRQAGYEVAIDDFGTGYSNLHNLYSLNIDLLKIDKSFVDTLTTNSASHLIVEHIIEMAQSLRLKIIAEGV
ETAEQVSWLLKRGVQYCQGWHFAKALPPQEFIAWLQQTPAPLTIRGQTPYRR

Specific function: Overexpression reduces biofilm formation [H]

COG id: COG4943

COG function: function code T; Predicted signal transduction protein containing sensor and EAL domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI1790496, Length=528, Percent_Identity=64.9621212121212, Blast_Score=707, Evalue=0.0,
Organism=Escherichia coli, GI87081743, Length=519, Percent_Identity=33.140655105973, Blast_Score=301, Evalue=8e-83,
Organism=Escherichia coli, GI87081845, Length=279, Percent_Identity=31.1827956989247, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI87081921, Length=254, Percent_Identity=38.1889763779528, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788502, Length=253, Percent_Identity=32.4110671936759, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787541, Length=245, Percent_Identity=33.469387755102, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081980, Length=252, Percent_Identity=33.7301587301587, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI226510982, Length=239, Percent_Identity=36.8200836820084, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1786507, Length=244, Percent_Identity=31.5573770491803, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788849, Length=235, Percent_Identity=32.3404255319149, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI87082096, Length=239, Percent_Identity=31.3807531380753, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1787055, Length=247, Percent_Identity=29.5546558704453, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787410, Length=164, Percent_Identity=29.8780487804878, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: NA

Molecular weight: Translated: 61119; Mature: 60987

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSTRRKVLRFLGTIIVVLLPILLAIWFAHIRAVSETRNQLHSFAQLVLDKTERVILQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLARDAAEQYQGQACTPAHQQRMLNIIRGRLYINELIYAKGQRFLCSTVMTPTSPYFIPR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEECC
ADYKRKPDIAIYYYRDTPFFNGYKMTYMQRGNYVAVINPLSYSEVMSDDPALAWGMYDTV
CCCCCCCCEEEEEEECCCCCCCEEEEEEECCCEEEEECCCCHHHHHCCCCCEEHHHHHHH
TNTFFSLSEQAQADQLLPLVRRSEPVFQQGERFYTLVKSAKRPVAAIVSTSKQRFYQNLF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
HQLTLTLPLGIICSIIILFMWSRSRQAYYSPRRLLQRAITRHQLCLHYQPIIDIRNGTCV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEE
GAEALLRWPGYHGPVMSPCEFIPLAEKEGMIEQITDYVVEEVFNDLGGFLAAHPHLYVSI
CHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
NLAAADFLSSRLIVMIHEKTRQHSVLAQQIKVEVTERGFIDVPKMTPIIQAFRQAGYEVA
EHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHCCCEEE
IDDFGTGYSNLHNLYSLNIDLLKIDKSFVDTLTTNSASHLIVEHIIEMAQSLRLKIIAEG
ECCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VETAEQVSWLLKRGVQYCQGWHFAKALPPQEFIAWLQQTPAPLTIRGQTPYRR
HHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure 
SQSTRRKVLRFLGTIIVVLLPILLAIWFAHIRAVSETRNQLHSFAQLVLDKTERVILQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLARDAAEQYQGQACTPAHQQRMLNIIRGRLYINELIYAKGQRFLCSTVMTPTSPYFIPR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEECC
ADYKRKPDIAIYYYRDTPFFNGYKMTYMQRGNYVAVINPLSYSEVMSDDPALAWGMYDTV
CCCCCCCCEEEEEEECCCCCCCEEEEEEECCCEEEEECCCCHHHHHCCCCCEEHHHHHHH
TNTFFSLSEQAQADQLLPLVRRSEPVFQQGERFYTLVKSAKRPVAAIVSTSKQRFYQNLF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
HQLTLTLPLGIICSIIILFMWSRSRQAYYSPRRLLQRAITRHQLCLHYQPIIDIRNGTCV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEE
GAEALLRWPGYHGPVMSPCEFIPLAEKEGMIEQITDYVVEEVFNDLGGFLAAHPHLYVSI
CHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
NLAAADFLSSRLIVMIHEKTRQHSVLAQQIKVEVTERGFIDVPKMTPIIQAFRQAGYEVA
EHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHCCCEEE
IDDFGTGYSNLHNLYSLNIDLLKIDKSFVDTLTTNSASHLIVEHIIEMAQSLRLKIIAEG
ECCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VETAEQVSWLLKRGVQYCQGWHFAKALPPQEFIAWLQQTPAPLTIRGQTPYRR
HHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]