| Definition | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome. |
|---|---|
| Accession | NC_003197 |
| Length | 4,857,432 |
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The map label for this gene is uvrA [H]
Identifier: 16767504
GI number: 16767504
Start: 4473213
End: 4476038
Strand: Reverse
Name: uvrA [H]
Synonym: STM4254
Alternate gene names: 16767504
Gene position: 4476038-4473213 (Counterclockwise)
Preceding gene: 16767513
Following gene: 16767503
Centisome position: 92.15
GC content: 57.11
Gene sequence:
>2826_bases ATGGATAAGATCGAAGTTCGGGGCGCCCGCACCCATAATCTCAAAAATATTAACCTCGTCATCCCCCGCGACAAACTGAT TGTCGTGACCGGGCTTTCGGGTTCAGGCAAATCCTCACTGGCTTTCGACACTCTGTATGCCGAAGGGCAGCGTCGTTACG TTGAATCGCTCTCCGCTTACGCGCGGCAGTTTTTGTCGCTCATGGAAAAACCGGATGTCGACCATATTGAGGGGCTATCG CCCGCGATCTCAATTGAACAGAAATCGACATCGCACAACCCGCGCTCTACGGTGGGTACTATTACCGAGATCCACGACTA CCTGCGCCTGCTGTTTGCCCGCGTGGGCGAGCCGCGTTGTCCGGATCATGACGTGCCGCTGGCGGCGCAAACCGTTAGCC AGATGGTCGATAACGTGCTGTCACAGCCGGAAGGCAAACGTCTGATGCTGCTCGCGCCGATTATTAAAGAGCGTAAAGGC GAACACACCAAAACGCTGGAAAATCTGGCAAGCCAGGGTTACATTCGCGCCCGTATTGACGGCGAAGTCTGCGATCTCTC CGATCCGCCGAAGCTGGAGCTACAAAAGAAACATACCATTGAGGTGGTGATCGATCGCTTCAAAGTTCGCAACGATCTTT CCCAACGCCTGGCGGAGTCGTTCGAAACGGCGCTGGAATTATCCGGCGGCACGGCGGTTGTTGCCGATATGGACGATGAG AAAGCGGAGGAGCTTCTGTTCTCCGCCAATTTTGCCTGTCCGATTTGCGGCTACAGTATGCGCGAGCTGGAACCGCGTCT GTTCTCGTTCAACAACCCGGCAGGCGCCTGCCCGACCTGTGACGGCCTCGGCGTTCAGCAATATTTCGATCCGGACCGCG TGATCCAGAATCCCGACCTGTCGCTGGCAGGCGGCGCGATTCGTGGTTGGGATCGTCGCAATTTTTACTACTTTCAAATG CTCAAGTCGCTGGCGGAACACTATAAGTTCGACGTAGATGCGCCGTGGGCAAGCCTCAGCGCCAACGTACATAAAGTCGT GCTGTACGGTTCCGGCAAAGAGAACATTGAATTTAAATATATGAACGATCGCGGCGATACCTCCGTGCGCCGCCATCCGT TCGAAGGCGTGCTGCATAATATGGAGCGCCGTTATAAAGAGACGGAATCCAGCGCGGTGCGCGAAGAGCTGGCGAAGTTC ATCAGTAATCGCCCCTGCGCCAGCTGTGAAGGCACGCGACTGAATCGCGAAGCGCGCCATGTATTTGTGGAAAATACGCC GCTGCCTGCTATTTCTGATATGAGCATTGGCCATGCGATGGATTTTTTCACTAATCTCAAGCTTTCCGGGCAACGAGCGA AAATCGCCGAAAAAGTGCTAAAAGAGATCGGCGATCGCCTCAAGTTTCTGGTGAACGTCGGCCTGAACTATCTCACGCTC TCCCGCTCGGCAGAGACGCTTTCCGGCGGCGAAGCCCAGCGTATTCGTCTGGCGAGCCAGATAGGCGCCGGGTTAGTCGG CGTGATGTATGTGCTGGATGAGCCGTCCATCGGTCTGCACCAGCGCGATAACGAACGGCTGCTGGGTACGCTGATTCATC TGCGCAATCTTGGCAATACCGTGATTGTGGTGGAACACGATGAAGACGCCATTCGCGCCGCCGACCATGTGATTGATATT GGCCCCGGCGCGGGCGTTCACGGCGGCGAGGTGGTGGCGGAAGGCCCGCTGGAAGCCATTATGGCGGTACCGGAATCGCT GACCGGCCAGTACATGAGCGGTAAACGCAAAATTGAAGTGCCGAAACAACGCGTGCCGGCAAATCCAGAAAAAGTGCTCA AACTCACCGGCGCGCGCGGCAACAACCTGAAAGATGTGACCCTTACGCTACCGGTAGGGCTGTTTACCTGTATCACCGGC GTCTCGGGTTCCGGTAAATCGACGCTGATTAACGACACGCTGTTCCCCATCGCCCAGCGTCAGTTAAACGGGGCGACTAT CGCCGAACCGGCGCCGTATCGGGATATTCAGGGGCTGGAACATTTCGATAAAGTGATCGATATCGACCAGAGCCCAATCG GGCGCACCCCGCGTTCCAACCCGGCGACCTATACGGGCGTCTTTACCCCGGTTCGCGAGCTTTTTGCTGGCGTGCCGGAG TCTCGCTCGCGCGGCTACACGCCAGGGCGATTCAGCTTCAACGTGCGCGGCGGTCGCTGCGAAGCGTGCCAGGGCGATGG CGTCATTAAAGTCGAAATGCACTTTCTGCCGGATATTTACGTGCCGTGCGACCAGTGCAAAGGCAAGCGCTATAACCGGG AAACGCTGGAGATTAAGTACAAAGGCAAGACCATCCACGAAGTGCTGGATATGACCATTGAAGAAGCGCGTGAGTTCTTT GATGCGGTTCCGGCGCTGGCGCGTAAGCTGCAGACGCTGATGGACGTAGGGCTGACCTATATCCGTCTTGGTCAGTCGGC GACAACGCTTTCCGGCGGCGAGGCCCAGCGCGTGAAGCTGGCGCGCGAACTGTCGAAGCGCGGCACCGGGCAGACGCTGT ATATTCTCGACGAGCCAACCACCGGCCTGCACTTTGCCGATATTCAGCAGTTGCTTGACGTTCTGCATCAGTTGCGCGAT CAGGGCAACACCATCGTGGTGATCGAACACAACCTGGACGTCATTAAAACGGCGGACTGGATTGTCGACCTCGGCCCGGA AGGCGGCAGCGGCGGCGGCGAAATTCTCGTCGCCGGTACGCCGGAAACCGTGGCGGAGTGCGAGGCGTCGCATACCGCCC GCTTCCTTAAACCTATGCTCAAATAA
Upstream 100 bases:
>100_bases TACTGTATATTCAAACAGGTTAAATTGTGTCATAATTAGCCGTTTCTGCCGTTTGTCCTTCAAACAAACCAGGCATCCGA GTCTCTACCGGGAAAGGTGA
Downstream 100 bases:
>100_bases CCTTCACGCCGCTTTCCGATTCGCCGGGAAGCGGCATCATTTTTCCTCATCCCACCTCATTGTATCCGTGTTGAGCATTT GTGATTTGCGTGCCGCCTCG
Product: excinuclease ABC subunit A
Products: NA
Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]
Number of amino acids: Translated: 941; Mature: 941
Protein sequence:
>941_residues MDKIEVRGARTHNLKNINLVIPRDKLIVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLS PAISIEQKSTSHNPRSTVGTITEIHDYLRLLFARVGEPRCPDHDVPLAAQTVSQMVDNVLSQPEGKRLMLLAPIIKERKG EHTKTLENLASQGYIRARIDGEVCDLSDPPKLELQKKHTIEVVIDRFKVRNDLSQRLAESFETALELSGGTAVVADMDDE KAEELLFSANFACPICGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQNPDLSLAGGAIRGWDRRNFYYFQM LKSLAEHYKFDVDAPWASLSANVHKVVLYGSGKENIEFKYMNDRGDTSVRRHPFEGVLHNMERRYKETESSAVREELAKF ISNRPCASCEGTRLNREARHVFVENTPLPAISDMSIGHAMDFFTNLKLSGQRAKIAEKVLKEIGDRLKFLVNVGLNYLTL SRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLIHLRNLGNTVIVVEHDEDAIRAADHVIDI GPGAGVHGGEVVAEGPLEAIMAVPESLTGQYMSGKRKIEVPKQRVPANPEKVLKLTGARGNNLKDVTLTLPVGLFTCITG VSGSGKSTLINDTLFPIAQRQLNGATIAEPAPYRDIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGVFTPVRELFAGVPE SRSRGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDIYVPCDQCKGKRYNRETLEIKYKGKTIHEVLDMTIEEAREFF DAVPALARKLQTLMDVGLTYIRLGQSATTLSGGEAQRVKLARELSKRGTGQTLYILDEPTTGLHFADIQQLLDVLHQLRD QGNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGEILVAGTPETVAECEASHTARFLKPMLK
Sequences:
>Translated_941_residues MDKIEVRGARTHNLKNINLVIPRDKLIVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLS PAISIEQKSTSHNPRSTVGTITEIHDYLRLLFARVGEPRCPDHDVPLAAQTVSQMVDNVLSQPEGKRLMLLAPIIKERKG EHTKTLENLASQGYIRARIDGEVCDLSDPPKLELQKKHTIEVVIDRFKVRNDLSQRLAESFETALELSGGTAVVADMDDE KAEELLFSANFACPICGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQNPDLSLAGGAIRGWDRRNFYYFQM LKSLAEHYKFDVDAPWASLSANVHKVVLYGSGKENIEFKYMNDRGDTSVRRHPFEGVLHNMERRYKETESSAVREELAKF ISNRPCASCEGTRLNREARHVFVENTPLPAISDMSIGHAMDFFTNLKLSGQRAKIAEKVLKEIGDRLKFLVNVGLNYLTL SRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLIHLRNLGNTVIVVEHDEDAIRAADHVIDI GPGAGVHGGEVVAEGPLEAIMAVPESLTGQYMSGKRKIEVPKQRVPANPEKVLKLTGARGNNLKDVTLTLPVGLFTCITG VSGSGKSTLINDTLFPIAQRQLNGATIAEPAPYRDIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGVFTPVRELFAGVPE SRSRGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDIYVPCDQCKGKRYNRETLEIKYKGKTIHEVLDMTIEEAREFF DAVPALARKLQTLMDVGLTYIRLGQSATTLSGGEAQRVKLARELSKRGTGQTLYILDEPTTGLHFADIQQLLDVLHQLRD QGNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGEILVAGTPETVAECEASHTARFLKPMLK >Mature_941_residues MDKIEVRGARTHNLKNINLVIPRDKLIVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLS PAISIEQKSTSHNPRSTVGTITEIHDYLRLLFARVGEPRCPDHDVPLAAQTVSQMVDNVLSQPEGKRLMLLAPIIKERKG EHTKTLENLASQGYIRARIDGEVCDLSDPPKLELQKKHTIEVVIDRFKVRNDLSQRLAESFETALELSGGTAVVADMDDE KAEELLFSANFACPICGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQNPDLSLAGGAIRGWDRRNFYYFQM LKSLAEHYKFDVDAPWASLSANVHKVVLYGSGKENIEFKYMNDRGDTSVRRHPFEGVLHNMERRYKETESSAVREELAKF ISNRPCASCEGTRLNREARHVFVENTPLPAISDMSIGHAMDFFTNLKLSGQRAKIAEKVLKEIGDRLKFLVNVGLNYLTL SRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLIHLRNLGNTVIVVEHDEDAIRAADHVIDI GPGAGVHGGEVVAEGPLEAIMAVPESLTGQYMSGKRKIEVPKQRVPANPEKVLKLTGARGNNLKDVTLTLPVGLFTCITG VSGSGKSTLINDTLFPIAQRQLNGATIAEPAPYRDIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGVFTPVRELFAGVPE SRSRGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDIYVPCDQCKGKRYNRETLEIKYKGKTIHEVLDMTIEEAREFF DAVPALARKLQTLMDVGLTYIRLGQSATTLSGGEAQRVKLARELSKRGTGQTLYILDEPTTGLHFADIQQLLDVLHQLRD QGNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGEILVAGTPETVAECEASHTARFLKPMLK
Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h
COG id: COG0178
COG function: function code L; Excinuclease ATPase subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ABC transporter domains [H]
Homologues:
Organism=Escherichia coli, GI2367343, Length=940, Percent_Identity=97.8723404255319, Blast_Score=1882, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR013815 - InterPro: IPR004602 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 103930; Mature: 103930
Theoretical pI: Translated: 6.55; Mature: 6.55
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDKIEVRGARTHNLKNINLVIPRDKLIVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAY CCCEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHH ARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEIHDYLRLLFARVGEPRC HHHHHHHHCCCCCCHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC PDHDVPLAAQTVSQMVDNVLSQPEGKRLMLLAPIIKERKGEHTKTLENLASQGYIRARID CCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCHHHHHHHHHHCCEEEEEEC GEVCDLSDPPKLELQKKHTIEVVIDRFKVRNDLSQRLAESFETALELSGGTAVVADMDDE CCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH KAEELLFSANFACPICGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQNPDL HHHHHHHHCCCCCCCCCCHHHHCCCHHEECCCCCCCCCCCCCCCCHHHCCHHHHCCCCCC SLAGGAIRGWDRRNFYYFQMLKSLAEHYKFDVDAPWASLSANVHKVVLYGSGKENIEFKY CCCCCCCCCCCCCCHHHHHHHHHHHHHCEECCCCCHHHHCCCEEEEEEECCCCCCEEEEE MNDRGDTSVRRHPFEGVLHNMERRYKETESSAVREELAKFISNRPCASCEGTRLNREARH ECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE VFVENTPLPAISDMSIGHAMDFFTNLKLSGQRAKIAEKVLKEIGDRLKFLVNVGLNYLTL EEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE SRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLIHLRNLGNT CCCCCCCCCCCHHHHHHHHHHCCCCEEHEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCE VIVVEHDEDAIRAADHVIDIGPGAGVHGGEVVAEGPLEAIMAVPESLTGQYMSGKRKIEV EEEEECCCHHHHHHCCEEECCCCCCCCCCCEEECCHHHHHHHCCHHHCCHHHCCCEEECC PKQRVPANPEKVLKLTGARGNNLKDVTLTLPVGLFTCITGVSGSGKSTLINDTLFPIAQR CHHHCCCCHHHHHEEECCCCCCCEEEEEEEHHHHHHHHHCCCCCCCCEEECCHHHHHHHH QLNGATIAEPAPYRDIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGVFTPVRELFAGVPE HCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCC SRSRGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDIYVPCDQCKGKRYNRETLEIKY CCCCCCCCCEEEEEECCCEECCCCCCCEEEEEEEECCCCCCCCHHHCCCCCCCCEEEEEE KGKTIHEVLDMTIEEAREFFDAVPALARKLQTLMDVGLTYIRLGQSATTLSGGEAQRVKL CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCHHHHHH ARELSKRGTGQTLYILDEPTTGLHFADIQQLLDVLHQLRDQGNTIVVIEHNLDVIKTADW HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCE IVDLGPEGGSGGGEILVAGTPETVAECEASHTARFLKPMLK EEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MDKIEVRGARTHNLKNINLVIPRDKLIVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAY CCCEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHH ARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEIHDYLRLLFARVGEPRC HHHHHHHHCCCCCCHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC PDHDVPLAAQTVSQMVDNVLSQPEGKRLMLLAPIIKERKGEHTKTLENLASQGYIRARID CCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCHHHHHHHHHHCCEEEEEEC GEVCDLSDPPKLELQKKHTIEVVIDRFKVRNDLSQRLAESFETALELSGGTAVVADMDDE CCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH KAEELLFSANFACPICGYSMRELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVIQNPDL HHHHHHHHCCCCCCCCCCHHHHCCCHHEECCCCCCCCCCCCCCCCHHHCCHHHHCCCCCC SLAGGAIRGWDRRNFYYFQMLKSLAEHYKFDVDAPWASLSANVHKVVLYGSGKENIEFKY CCCCCCCCCCCCCCHHHHHHHHHHHHHCEECCCCCHHHHCCCEEEEEEECCCCCCEEEEE MNDRGDTSVRRHPFEGVLHNMERRYKETESSAVREELAKFISNRPCASCEGTRLNREARH ECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE VFVENTPLPAISDMSIGHAMDFFTNLKLSGQRAKIAEKVLKEIGDRLKFLVNVGLNYLTL EEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE SRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLIHLRNLGNT CCCCCCCCCCCHHHHHHHHHHCCCCEEHEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCE VIVVEHDEDAIRAADHVIDIGPGAGVHGGEVVAEGPLEAIMAVPESLTGQYMSGKRKIEV EEEEECCCHHHHHHCCEEECCCCCCCCCCCEEECCHHHHHHHCCHHHCCHHHCCCEEECC PKQRVPANPEKVLKLTGARGNNLKDVTLTLPVGLFTCITGVSGSGKSTLINDTLFPIAQR CHHHCCCCHHHHHEEECCCCCCCEEEEEEEHHHHHHHHHCCCCCCCCEEECCHHHHHHHH QLNGATIAEPAPYRDIQGLEHFDKVIDIDQSPIGRTPRSNPATYTGVFTPVRELFAGVPE HCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCC SRSRGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDIYVPCDQCKGKRYNRETLEIKY CCCCCCCCCEEEEEECCCEECCCCCCCEEEEEEEECCCCCCCCHHHCCCCCCCCEEEEEE KGKTIHEVLDMTIEEAREFFDAVPALARKLQTLMDVGLTYIRLGQSATTLSGGEAQRVKL CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCHHHHHH ARELSKRGTGQTLYILDEPTTGLHFADIQQLLDVLHQLRDQGNTIVVIEHNLDVIKTADW HHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCE IVDLGPEGGSGGGEILVAGTPETVAECEASHTARFLKPMLK EEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: DNA [C]
Specific reaction: Protein + DNA = Protein-DNA [C]
General reaction: Hydrolase; Acting on ester bonds [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11586360; 12142430 [H]