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The map label for this gene is tyrB

Identifier: 16767498

GI number: 16767498

Start: 4469303

End: 4470496

Strand: Direct

Name: tyrB

Synonym: STM4248

Alternate gene names: 16767498

Gene position: 4469303-4470496 (Clockwise)

Preceding gene: 16767497

Following gene: 16767499

Centisome position: 92.01

GC content: 55.53

Gene sequence:

>1194_bases
GTGTTTCAAAAAGTTGACGCCTATGCCGGCGATCCGATTCTTTCACTGATGGAGCGTTTTAAAGACGACTCCCGTCACGA
CAAAGTGAATCTGAGCATTGGCCTGTATTACAACGAAGACGGGATTATCCCACAGCTTAAAACGGTGGCCGAAGCCGAAG
CCCGGCTTAACGCGCAGCCGCATGGCGCTTCGCTGTACCTGCCGATGGAAGGACTCAATACTTATCGCCATACTATCGCG
CCTTTGCTCTTTGGCGCCGATCACCCGGTTCTTCAGCAACAGCGCGTGGCCACTATCCAGACATTAGGCGGCTCCGGCGC
GCTGAAAGTAGGCGCGGATTTCCTGAAGCGTTATTTCCCCGACGCAGGCGTATGGGTGAGCGACCCCACCTGGGAAAACC
ATATTGCGATATTTGCCGGGGCAGGATTCGAAGTGAGTACTTACCCCTGGTATGACGACGCGACTAACGGCATCCGTTTT
AACGATCTGCTGGCCACGCTGAATACGTTACCTGCGCGCAGTATCGTGTTGCTGCACCCCTGTTGTCACAACCCGACCGG
GGCGGATTTAACGCCTTCGCAATGGGATGCGGTGATTGAAATAGTGAAAGCGCGCGATCTGATTCCGTTTCTTGATATTG
CCTATCAGGGGTTTGGCGCAGGCATGGACGATGATGCGTACGTTATTCGCGCCATTGCCAGCGCTGGGTTACCTGCGTTA
GTCAGTAATTCTTTTTCGAAGATTTTCTCGCTGTACGGCGAGCGCGTCGGCGGCCTGTCCGTGGTGTGTGAAGATGCTGA
AATCGCCGCGCGGGTTCTGGGACAGCTAAAAGCGACGGTGCGCCGAATTTACTCCAGTCCGCCGTGTTTCGGCGCTCAGG
TGGTCGCTACGGTCCTGGGCGATGAGGCGTTAAAAGCGGGCTGGCTGGCGGAAGTCGACGCGATGCGTAACCGCATTATA
TCGATGCGCCAGACGCTGGTGAAGGAGCTGAAGGCGGAGATGCCTGACCGCAACTTTGATTACTTGTTACAGCAGCGCGG
TATGTTCAGCTATACCGGGTTAAGCGAGGAGCAGGTCGATCGGTTGCGCGATGAGTTTGGCGTTTACCTGATTGCCAGTG
GCCGCATGTGTGTCGCCGGGCTTAATGCTTCAAATGTACACCGCGTGGCGAAGGCATTTGCCGCTGTCATGTAA

Upstream 100 bases:

>100_bases
TCCGGTAATATGCGCATCCACCACAACATCCTCTCGATCTTCTCGTCCTTCCGGTTTATTGTGTTATTTCCTGCCCTCTG
TAAACCTGGAGAACCATCGC

Downstream 100 bases:

>100_bases
TATTCAGGCCGGACGGCGATAACAGTGCCCTCCGGCCTGACAATAGCTGTTGTGATCATCCTCTTTTTTCGTAACAAAAC
CGCAGATAATCCTTCCTTTT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDDDAYVIRAIASAGLPAL
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKAGWLAEVDAMRNRII
SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVDRLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM

Sequences:

>Translated_397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDDDAYVIRAIASAGLPAL
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKAGWLAEVDAMRNRII
SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVDRLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
>Mature_397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDDDAYVIRAIASAGLPAL
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKAGWLAEVDAMRNRII
SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVDRLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=42.0103092783505, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI4504067, Length=390, Percent_Identity=40.5128205128205, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=25.7217847769029, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=88.1612090680101, Blast_Score=733, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=42.5692695214106, Blast_Score=340, Evalue=8e-95,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=38.6363636363636, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI25147133, Length=390, Percent_Identity=41.025641025641, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17569539, Length=393, Percent_Identity=38.4223918575064, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17569537, Length=390, Percent_Identity=31.5384615384615, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=35.7414448669202, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25147136, Length=206, Percent_Identity=37.8640776699029, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=36.5432098765432, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6322743, Length=424, Percent_Identity=34.4339622641509, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=39.7932816537468, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=39.7932816537468, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=38.2871536523929, Blast_Score=287, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=38.2871536523929, Blast_Score=287, Evalue=9e-78,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=38.659793814433, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYRB_SALTY (P74861)

Other databases:

- EMBL:   Z68874
- EMBL:   AE006468
- PIR:   S71928
- RefSeq:   NP_463113.1
- ProteinModelPortal:   P74861
- SMR:   P74861
- PRIDE:   P74861
- GeneID:   1255774
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM4248
- NMPDR:   fig|99287.1.peg.4086
- HOGENOM:   HBG446828
- OMA:   CVAGLNS
- ProtClustDB:   PRK09257
- BioCyc:   STYP99287:STM4248-MONOMER
- BRENDA:   2.6.1.57
- GO:   GO:0005737
- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11879
- PRINTS:   PR00799

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.57

Molecular weight: Translated: 43527; Mature: 43527

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 66-66 BINDING 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQP
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
HGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP
CCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLPARSIVLLHP
CCCCEECCCCCCCCEEEEEECCCEECCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDDDAYVIRAIASAGLPAL
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHH
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLG
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DEALKAGWLAEVDAMRNRIISMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVD
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
HHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQP
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
HGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP
CCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLPARSIVLLHP
CCCCEECCCCCCCCEEEEEECCCEECCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDDDAYVIRAIASAGLPAL
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHH
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLG
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DEALKAGWLAEVDAMRNRIISMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVD
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
HHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8809108; 11677609