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The map label for this gene is hemE [H]

Identifier: 16767421

GI number: 16767421

Start: 4384145

End: 4385209

Strand: Direct

Name: hemE [H]

Synonym: STM4167

Alternate gene names: 16767421

Gene position: 4384145-4385209 (Clockwise)

Preceding gene: 16767420

Following gene: 16767422

Centisome position: 90.26

GC content: 57.56

Gene sequence:

>1065_bases
ATGACCGAACTCAAAAACGATCGTTATCTACGTGCGCTGCTGCGCCAGCCCGTTGATGTTACGCCAGTGTGGATGATGCG
CCGGGCGGGCCGTTATCTACCGGAGTACAAAGCCACTCGCGCTCAGGCGGGCGATTTTATGTCGCTGTGCAAAAATGCCG
AACTGGCCTGCGAGGTCACTTTACAGCCGCTGCGCCGTTATCCGCTTGATGCGGCGATCCTTTTCTCGGATATCCTGACG
ATTCCGGACGCGATGGGCCTGGGGCTCTATTTTGAAGCTGGGGAAGGCCCGCGCTTTACAGCCCCTGTCACCTGCAAAGC
CGACGTTGAAAAACTGCCGATTCCGGATCCAGAAGGTGAACTGGGCTACGTGATGAATGCGGTGCGTACGATTCGCCGCG
AACTAAAAGGCGAGGTTCCTCTGATCGGCTTCTCCGGCAGCCCGTGGACGCTGGCGACTTACATGGTGGAAGGCGGCAGT
AGCAAAGCCTTCACGGTGATTAAAAAGATGATGTACGCTGACCCGCAGGCGTTGCATCTGCTGCTGGATAAGTTGGCGAA
AAGCGTCACGCTGTACCTCAACGCGCAGATTAAAGCGGGTGCGCAGTCGGTGATGATTTTCGATACCTGGGGCGGCGTGC
TGACTGGCCGCGATTACCAGCAATTCTCCCTCTACTACATGCATAAAATCGTCGATGGCCTGCTGCGTGAAAACGACGGT
CGCCGGGTGCCGGTAACGCTGTTCACTAAAGGTGGCGGTCAGTGGCTGGAGGCGATGGCGGAAACCGGCTGCGACGCGCT
GGGTCTCGACTGGACGACAGATATCGCCGATGCGCGCCGTCGCGTTGGCCATAAAGTGGCGCTGCAGGGCAATATGGACC
CCTCGATGCTGTATGCGCCGCCGGCACGGATCGAAGACGAAGTAGCGACTATACTTGCTGGTTTCGGTCAGGGAGAAGGG
CACGTCTTTAACCTTGGACATGGCATCCATCAGGATGTGCCGCCAGAACATGCTGGCGCATTTGTGGAGGCAGTGCACCG
ACTTTCTGCGCAGTATCACAACTAA

Upstream 100 bases:

>100_bases
ACCGTCGCGCGCCGTTTGATCGAAGATACGGTGGCAATGTGTCGGGCTGAATATGATTGACATGTTACACTGGGCGCATC
AACGCTAAAGGAATGTAAAA

Downstream 100 bases:

>100_bases
GGAGTTAGCATGGATCTCGCGTCGCTACGCGCTCAACAGATAGAACTTGCTTCATCGGTTTGCCGCGAAGATCGGTTGGA
CAAAGATCCGCCAGCGTTTA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRRAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
IPDAMGLGLYFEAGEGPRFTAPVTCKADVEKLPIPDPEGELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYADPQALHLLLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAPPARIEDEVATILAGFGQGEG
HVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN

Sequences:

>Translated_354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRRAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
IPDAMGLGLYFEAGEGPRFTAPVTCKADVEKLPIPDPEGELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYADPQALHLLLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAPPARIEDEVATILAGFGQGEG
HVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN
>Mature_353_residues
TELKNDRYLRALLRQPVDVTPVWMMRRAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTI
PDAMGLGLYFEAGEGPRFTAPVTCKADVEKLPIPDPEGELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFTVIKKMMYADPQALHLLLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGR
RVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAPPARIEDEVATILAGFGQGEGH
VFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=48.1586402266289, Blast_Score=313, Evalue=1e-85,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=96.600566572238, Blast_Score=710, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=37.9213483146067, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=42.3631123919308, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=42.3631123919308, Blast_Score=285, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39161; Mature: 39029

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNDRYLRALLRQPVDVTPVWMMRRAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTIPDAMGLGLYFEAGEGPRFTAPVTCKADVEKLPIPDPEGE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECCEEECCCCCCCCCCCCCCH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
HHHHHHHHEEEEEEEEEECCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEDEVATILAGFGQGEGHVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TELKNDRYLRALLRQPVDVTPVWMMRRAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTIPDAMGLGLYFEAGEGPRFTAPVTCKADVEKLPIPDPEGE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECCEEECCCCCCCCCCCCCCH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHL
HHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
HHHHHHHHEEEEEEEEEECCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEDEVATILAGFGQGEGHVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHN
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA