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The map label for this gene is hemD

Identifier: 16767208

GI number: 16767208

Start: 4144312

End: 4145052

Strand: Reverse

Name: hemD

Synonym: STM3937

Alternate gene names: 16767208

Gene position: 4145052-4144312 (Counterclockwise)

Preceding gene: 16767209

Following gene: 16767207

Centisome position: 85.33

GC content: 57.62

Gene sequence:

>741_bases
ATGAGTATTCTGATCACCCGCCCCTCTCCCGCAGGGGAAGCGTTAGTGAGCCGTCTGCGCGCACTGGGGCAGGTGGCCTG
GAGTTTTCCACTGATTGAATTTGTCGCCGGTCGGGAGCTACCCACCCTGGCCGACCGCCTGGCGACGCTGACGGAAAACG
ATCTGGTTTTTGCCCTTTCACAGCACGCTGTCGCCTTTGCTCACGCCCAGCTCCAGCGGGATGGTCGAAACTGGCCTGTG
GCGCCGCGCTATTTCGCGATTGGCCGCACCACGGCGCTCGCCCTTCATACCGTTAGCGGGTTCGATATTCGTTATCCATT
GGATCGGGAAATCAGCGAAGCCTTGCTACAATTACCTGAATTACAAAATATTGCGGGCAAACGCGCGCTGATTTTGCGTG
GCAATGGCGGCCGCGAACTGCTGGGCGAAACCCTGACAGCGCGCGGAGCCGAAGTCAGTTTTTGTGAATGTTATCAACGA
TGTGCGAAACATTACGATGGCGCGGAAGAAGCGATGCGCTGGCATACTCGCGGCGTAACAACGCTTGTTGTTACCAGCGG
CGAGATGTTGCAACGGCTCTGGTCGCTGACTCCCCAGTGGTATCGTGAGCACTGGTTACTACGCTGTCGGCTATTGGTCG
TCAGTGAGCGTCTGGCGCACCTCGCCCGGGAACTGGGCTGGCAAGATATTAAGGTCGCTGATAACGCCGACAACGATGCG
CTGTTGCGCGCATTACAATAA

Upstream 100 bases:

>100_bases
CCGAGCAGGCGGAGCAAATGGGCATCTCGCTTGCAGAGGAACTGCTGGAAAACGGCGCACGCGCGATTCTGACGGAAGTT
TATAACGGCGAGACGCCCGC

Downstream 100 bases:

>100_bases
CTCTCATAATGGGATGCCATAATGACGGAACAAGAAAAATCCTCCGCCGTGGTTGATGAGACCAGGGAGAGCGTGGAAAC
CACGCCACAGCCAGTTAATA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALSQHAVAFAHAQLQRDGRNWPV
APRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPELQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQR
CAKHYDGAEEAMRWHTRGVTTLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDA
LLRALQ

Sequences:

>Translated_246_residues
MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALSQHAVAFAHAQLQRDGRNWPV
APRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPELQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQR
CAKHYDGAEEAMRWHTRGVTTLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDA
LLRALQ
>Mature_245_residues
SILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALSQHAVAFAHAQLQRDGRNWPVA
PRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPELQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRC
AKHYDGAEEAMRWHTRGVTTLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDAL
LRALQ

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family

Homologues:

Organism=Escherichia coli, GI1790236, Length=246, Percent_Identity=82.9268292682927, Blast_Score=414, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM4_SALTY (Q9L6Q3)

Other databases:

- EMBL:   AF233324
- EMBL:   AE006468
- RefSeq:   NP_462823.1
- ProteinModelPortal:   Q9L6Q3
- PRIDE:   Q9L6Q3
- GeneID:   1255463
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM3937
- NMPDR:   fig|99287.1.peg.3797
- HOGENOM:   HBG700564
- OMA:   NGGRDLI
- ProtClustDB:   PRK05928
- BioCyc:   STYP99287:STM3937-MONOMER
- BRENDA:   4.2.1.75
- InterPro:   IPR003754

Pfam domain/function: PF02602 HEM4; SSF69618 HEM4_synth

EC number: =4.2.1.75

Molecular weight: Translated: 27662; Mature: 27531

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHH
QHAVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPE
HHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHEEEECCCCEEECCCCHHHHHHHHHCCH
LQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT
HHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCE
TLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDA
EEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
LLRALQ
HHHHCC
>Mature Secondary Structure 
SILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHH
QHAVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPE
HHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHEEEECCCCEEECCCCHHHHHHHHHCCH
LQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT
HHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCE
TLVVTSGEMLQRLWSLTPQWYREHWLLRCRLLVVSERLAHLARELGWQDIKVADNADNDA
EEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
LLRALQ
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609