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The map label for this gene is wecC [H]

Identifier: 16767196

GI number: 16767196

Start: 4130417

End: 4131679

Strand: Direct

Name: wecC [H]

Synonym: STM3921

Alternate gene names: 16767196

Gene position: 4130417-4131679 (Clockwise)

Preceding gene: 16767195

Following gene: 16767197

Centisome position: 85.03

GC content: 56.77

Gene sequence:

>1263_bases
ATGAGTTTTACGACCATTTCTGTTATTGGGCTGGGGTATATCGGATTACCGACTGCGGCCGCTTTTGCTTCCCGCCAGAA
GCAGGTTATCGGCGTGGATATCAACCAACATGCGGTAGACATTATAAATCGCGGTGAAATTCACATCGTGGAGCCGGCGT
TGGGCAATGTGGTGAAGATGGCGGTGGAGGGCGGCTTTCTGCGTGCGACGACGACACCTGTCGAGGCCGATGCGTACCTG
ATTGCCGTGCCGACACCATTCAAAGGCGATCACGACCCTGACATGGCCTATGTCGAAGCCGCGGCGAAATCCATTGCGCC
AGTATTAAAAAAAGGGGCACTGGTGATTCTGGAATCAACATCGCCGGTCGGCGCAACGGAGCAAATGGCTGGCTGGCTGG
CCGGGATGCGCACGGATCTGACCTTTCCCCAGCAGGCGGGCGAGCAGGCCGATGTGAATATCGCCTATTGTCCGGAGCGT
GTGCTGCCGGGTCAGGTGATGGTGGAACTCATTAAAAATGACCGCGTGATTGGCGGTATGACGCCAGTATGTTCGGCTCG
CGCCAGCGCGCTGTACAAAATTTTCCTTGAGGGCGAATGCGTTGTCACCAACTCGCGCACCGCGGAGATGTGCAAACTGA
CGGAAAATAGCTTCCGTGATGTGAATATCGCCTTTGCGAATGAATTGTCGCTGATTTGCGCCGAACAGGGGATTAACGTT
TGGGAATTGATCCGCCTGGCGAACCGCCATCCGCGCGTCAATATTTTGCAGCCGGGCCCAGGCGTTGGCGGGCACTGCAT
TGCGGTCGATCCGTGGTTTATTGTGGCGCAAAATCCGCAGCAGGCGAGACTGATTCGCACCGCGCGTGAAGTGAACGACG
GCAAACCGCACTGGGTGGTCGATCAGGTAAAAGCCGCGGTCACAGATTGCCTGGCGGCCACCGATAAACGCGCCAGCGAA
GTGAAAATCGCCTGTTTTGGGCTGGCCTTTAAGCCGAATATCGACGATCTGCGCGAAAGCCCGGCGATGGGGATCGCGCA
AAGTATCGCCCGCTGGCACAGCGGCGAAACCCTGGTCGTCGAACCGAATATCCGTCAGTTGCCGAAAAAATTGGACGGAC
TTTGTACGCTGGCGAAACTGGACGCGGCGCTGGCCGCCGCCGATGTGCTGGTGATGCTGGTCGATCACGACGAATTTAAA
GCGATTCCCGGCGATGCGGTTCATCAACGTTATGTGGTTGATACCAAAGGAGTCTGGCGCTGA

Upstream 100 bases:

>100_bases
AAAATGAATATCAAACCATGAGCCGCGCCCATAATCCTTATGGTGACGGGCAATCATGCGCGCGCATTTTACAGGCGTTA
AAAAGTTATCGGGTATCGTT

Downstream 100 bases:

>100_bases
TGAAACGCATTCTGGTGACCGGCGGCGCAGGCTTTATCGGATCTGCGGTGGTGCGGCATATCATCCATGAAACGGCAGAC
GCGGTGGTGGTGGTGGATAA

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDIINRGEIHIVEPALGNVVKMAVEGGFLRATTTPVEADAYL
IAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILESTSPVGATEQMAGWLAGMRTDLTFPQQAGEQADVNIAYCPER
VLPGQVMVELIKNDRVIGGMTPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINV
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVVDQVKAAVTDCLAATDKRASE
VKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVVEPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFK
AIPGDAVHQRYVVDTKGVWR

Sequences:

>Translated_420_residues
MSFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDIINRGEIHIVEPALGNVVKMAVEGGFLRATTTPVEADAYL
IAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILESTSPVGATEQMAGWLAGMRTDLTFPQQAGEQADVNIAYCPER
VLPGQVMVELIKNDRVIGGMTPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINV
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVVDQVKAAVTDCLAATDKRASE
VKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVVEPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFK
AIPGDAVHQRYVVDTKGVWR
>Mature_419_residues
SFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDIINRGEIHIVEPALGNVVKMAVEGGFLRATTTPVEADAYLI
AVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILESTSPVGATEQMAGWLAGMRTDLTFPQQAGEQADVNIAYCPERV
LPGQVMVELIKNDRVIGGMTPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINVW
ELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVVDQVKAAVTDCLAATDKRASEV
KIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVVEPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFKA
IPGDAVHQRYVVDTKGVWR

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=442, Percent_Identity=26.6968325791855, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI296040438, Length=344, Percent_Identity=25.8720930232558, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI48994968, Length=420, Percent_Identity=90.2380952380952, Blast_Score=782, Evalue=0.0,
Organism=Escherichia coli, GI1788340, Length=430, Percent_Identity=23.953488372093, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=442, Percent_Identity=27.1493212669683, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17136908, Length=457, Percent_Identity=26.0393873085339, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45340; Mature: 45209

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDIINRGEIHIVEPALGNVVKM
CCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCHHHHHCCCCCEEEECCCHHHHHHH
AVEGGFLRATTTPVEADAYLIAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILEST
HHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
SPVGATEQMAGWLAGMRTDLTFPQQAGEQADVNIAYCPERVLPGQVMVELIKNDRVIGGM
CCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEECCC
TPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINV
CCHHHHHHHEEEEEEECCEEEEECCCCHHHHHHCCCCCCEEEEEEECCEEEEEHHCCCCH
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVV
HHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCHH
DQVKAAVTDCLAATDKRASEVKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVV
HHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEE
EPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFKAIPGDAVHQRYVVDTKGVWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHCCCCCHHHHCEEEECCCCCCC
>Mature Secondary Structure 
SFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDIINRGEIHIVEPALGNVVKM
CEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCHHHHHCCCCCEEEECCCHHHHHHH
AVEGGFLRATTTPVEADAYLIAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILEST
HHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
SPVGATEQMAGWLAGMRTDLTFPQQAGEQADVNIAYCPERVLPGQVMVELIKNDRVIGGM
CCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEECCC
TPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINV
CCHHHHHHHEEEEEEECCEEEEECCCCHHHHHHCCCCCCEEEEEEECCEEEEEHHCCCCH
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVV
HHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCHH
DQVKAAVTDCLAATDKRASEVKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVV
HHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEE
EPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFKAIPGDAVHQRYVVDTKGVWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHCCCCCHHHHCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]