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The map label for this gene is ilvD [H]

Identifier: 16767180

GI number: 16767180

Start: 4111987

End: 4113837

Strand: Direct

Name: ilvD [H]

Synonym: STM3904

Alternate gene names: 16767180

Gene position: 4111987-4113837 (Clockwise)

Preceding gene: 16767179

Following gene: 16767181

Centisome position: 84.65

GC content: 57.48

Gene sequence:

>1851_bases
ATGCCTAAGTACCGTTCCGCCACCACCACTCATGGTCGTAATATGGCGGGTGCCCGCGCGCTGTGGCGCGCCACCGGAAT
GACCGACAGTGATTTTGGCAAACCGATTATCGCCGTGGTGAACTCATTCACTCAGTTTGTGCCGGGTCACGTTCATCTGC
GCGATCTCGGTAAGCTGGTCGCCGAACAGATTGAAGCTTCCGGCGGGGTGGCGAAAGAGTTCAACACTATTGCCGTGGAT
GACGGGATTGCCATGGGGCACGGGGGTATGCTCTATTCACTGCCGTCGCGCGAGCTGATCGCCGACTCCGTTGAGTACAT
GGTGAACGCTCACTGCGCTGACGCGATGGTGTGTATCTCCAACTGCGACAAAATCACCCCAGGGATGCTCATGGCCTCGC
TGCGCCTGAATATTCCGGTGATCTTTGTCTCCGGCGGCCCGATGGAAGCCGGGAAAACCAAGCTTTCAGACAAAATTATC
AAGCTGGATCTGGTTGATGCCATGATTCAGGGAGCGGACCCGAAAGTCTCTGACGATCAAAGTAACCAGGTTGAACGCTC
CGCCTGTCCAACCTGCGGCTCCTGCTCCGGCATGTTTACCGCTAACTCCATGAACTGCCTGACCGAAGCGCTGGGCCTGT
CGCAGCCGGGCAACGGCTCGCTGCTGGCAACTCACGCTGACCGTAAGCAGTTGTTCCTCAATGCCGGTAAGCGGATTGTT
GAACTGACTAAACGCTATTACGAGCAAAACGACGAAAGTGCACTGCCGCGTAACATCGCCAGCAAAGCCGCGTTTGAAAA
CGCGATGACGCTGGATATCGCGATGGGCGGTTCGACCAACACCGTTCTTCACCTGCTGGCGGCGGCGCAGGAAGCGGAAA
TCGACTTCACCATGAGTGATATCGACAAGCTGTCCCGCAAGGTGCCGCAGCTGTGTAAAGTGGCGCCAAGTACCCAGAAA
TACCATATGGAAGATGTTCACCGTGCCGGCGGTGTGCTGGGTATTTTAGGCGAGCTGGATCGCGCCGGGCTGCTGAACCG
CAACGTGAAAAACGTATTAGGCCTGACGTTGCCGCAAACGCTGGAACAGTACGACATCACGGTTACGCAGGACGAAGCGG
TTAAAAAAATGTTCCGTGCTGGCCCTGCCGGTATCCGTACTACCCAGGCGTTCTCGCAGGATTGTCGCTGGGATTCGCTG
GATGACGACCGCGCAGCGGGTTGCATCCGCTCGCTGGAATATGCCTATAGCAAAGACGGCGGTCTGGCGGTGCTGTATGG
CAACTTCGCCGAAAACGGCTGCATTGTGAAAACCGCAGGCGTGGATGACAGCATCCTTAAATTTACCGGCCCGGCTAAAG
TGTATGAAAGCCAGGACGACGCGGTAGAGGCGATTCTCGGCGGCAAAGTAGTGGAAGGCGATGTAGTCGTGATCCGCTAC
GAAGGGCCGAAAGGCGGGCCGGGAATGCAGGAAATGCTCTATCCGACCAGTTTCCTGAAGTCGATGGGGCTGGGCAAAGC
CTGCGCGCTCATCACCGATGGGCGTTTCTCCGGCGGTACTTCGGGTCTTTCCATCGGCCACGTCTCGCCGGAAGCGGCCA
GCGGCGGCACTATTGCGTTGATTGAAGATGGCGACACTATTGCGATTGATATCCCGAACCGCAGCATTCAGTTGCAGTTG
AGTGAGGCTGAAATCGCCGCACGCCGCGAGGCGCAGGAAGCTCGTGGCGACAAAGCCTGGACGCCGAAAAATCGTCAGCG
TCAGGTTTCGTTTGCCCTGCGTGCCTACGCCAGCCTGGCGACCAGCGCCGATAAAGGCGCGGTGCGCGATAAATCGAAAT
TGGGAGGTTGA

Upstream 100 bases:

>100_bases
ATCCCCAGAAGCTTACTGTAGTAAGTGACTGGGGTGAGTGAGGCAGCCAACGCACCTGTGGCGTGAAGTATGAAGGGAAA
AGATGGGGAGTAAATAAAGC

Downstream 100 bases:

>100_bases
TGATGGCGGAATCTCAACCTCTGTCAGTCGCGCCGGAAGGGGCGGAGTATCTGCGCGCGGTGCTACGCGCGCCAGTATAC
GAAGCGGCGCAGGTGACACC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKII
KLDLVDAMIQGADPKVSDDQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
ELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQK
YHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQTLEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSL
DDDRAAGCIRSLEYAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIALIEDGDTIAIDIPNRSIQLQL
SEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG

Sequences:

>Translated_616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKII
KLDLVDAMIQGADPKVSDDQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
ELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQK
YHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQTLEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSL
DDDRAAGCIRSLEYAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIALIEDGDTIAIDIPNRSIQLQL
SEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG
>Mature_615_residues
PKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIK
LDLVDAMIQGADPKVSDDQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVE
LTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKY
HMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQTLEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSLD
DDRAAGCIRSLEYAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRYE
GPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIALIEDGDTIAIDIPNRSIQLQLS
EAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=95.9415584415584, Blast_Score=1229, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=30.0556586270872, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI2367371, Length=539, Percent_Identity=28.7569573283859, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1786464, Length=520, Percent_Identity=30, Blast_Score=171, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=615, Percent_Identity=37.5609756097561, Blast_Score=338, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65703; Mature: 65571

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLVDAMIQGADPKVSDDQ
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHEEEHHHHHHHHCCCCCCCCCCC
SNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
CCCHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSD
HHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
IDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCHHHHHCCCCHHH
LEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSLDDDRAAGCIRSLEYAYSKDG
HHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
CEEEEECCCCCCCCEEEECCCCCCCEEECCCHHHHCCCHHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIAL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
IEDGDTIAIDIPNRSIQLQLSEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLVDAMIQGADPKVSDDQ
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHEEEHHHHHHHHCCCCCCCCCCC
SNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
CCCHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSD
HHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
IDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCHHHHHCCCCHHH
LEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSLDDDRAAGCIRSLEYAYSKDG
HHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
CEEEEECCCCCCCCEEEECCCCCCCEEECCCHHHHCCCHHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIAL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
IEDGDTIAIDIPNRSIQLQLSEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA