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The map label for this gene is lyxK [H]

Identifier: 16766959

GI number: 16766959

Start: 3860963

End: 3862459

Strand: Direct

Name: lyxK [H]

Synonym: STM3674

Alternate gene names: 16766959

Gene position: 3860963-3862459 (Clockwise)

Preceding gene: 16766958

Following gene: 16766960

Centisome position: 79.49

GC content: 60.79

Gene sequence:

>1497_bases
ATGAGCAACTACTGGCTGGGGTTAGATTGTGGTGGGAGTTGGCTAAAAGCCGGGTTGTACGATGGCGCAGGCCGGGAAGT
AGCGGTGCAACGCCTGCCGCTGCACGCTTTAAGCCCGCAGCCAGGCTGGGTTGAACGCGATATGACCGAGCTGTGGCAAC
AGTGCGCCTCGGTCATCAGCAAACTGCTGGCGCACACGGGGGTGAGCGGCTCACAAATCCGCGGTCTGGGTATTTCCGCT
CAGGGTAAGGGCCTGTTCCTGTTAGATAAAAGCGATCGGCCATTAGGTAAAGCGATACTCTCTTCCGACCGTCGCGCCAT
GGAAATTGTCCAGCGCTGGCAAAAAGAAGCGGTTCCGCAAAAACTCTACCCGCTGACCCGGCAAACCCTGTGGACCGGGC
ATCCAGTCTCCCTTTTACGCTGGGTAAAAGAGAATGAGCCGCAGCGCTACGCGCAGATAGGCTGCGTCATGATGACGCAT
GACTATCTGCGCTGGTGCTTAACCGGCGTGAAAGGCTGTGAGGAGAGCAACATCTCCGAGTCCAACCTCTACAACATGGC
GACGGGCCAGTACGACCCGCGTCTGACCGAGTGGCTGGGCATCAGTGAAATCGACAGCGCGCTGTCCCCCGTGGTGGGTT
CAGCCGAAATATGCGGGGAGATCACCGCTCAGGCAGCCGCCATCACCGGTCTGGCGGCGGGTACCCCCGTCGTCGGCGGC
CTGTTTGATGTGGTTTCCACCGCCCTTTGCGCCGGTATTGAGGATGAATCGACCCTCAATGCGGTGATGGGCACCTGGGC
CGTCACCAGCGGCATCGCTCACGGCCTGCGCGACCATGAGGCCCACCCTTACGTCTATGGCCGCTACGTCAATGACGGGC
AGTATATCGTTCACGAAGCCAGCCCGACCTCCTCCGGCAACCTTGAATGGTTTACCGCCCAGTGGGGCGACCTCTCTTTT
GACGAGATCAATCAGGCGGTCGCCAGCCTGCCGAAAGCCGGTAGCGACCTTTTTTTTCTGCCGTTTCTCTACGGCAGCAA
TGCCGGACTGGAGATGACCTGCGGTTTTTACGGCATGCAGGCGCTGCACAACCGCGCGCACCTGCTACAGGCGCTCTATG
AAGGCGTGGTCTTCAGCCATATGACCCACCTCAACCGCATGCGTGAACGCTTTACCGAGGTTTGCGCCCTGCGCGTTACC
GGCGGCCCGGCCCACTCCGACGTCTGGATGCAGATGCTGGCGGACGTCAGCGGTTTACGCATTGAGCTGCCGCAGGTGGA
GGAGACCGGCTGCTTCGGCGCGGCGCTGGCTGCCCGCGTCGGCACCGGCGTATATCGCGATTTCCGCGAGGCCCAACGCG
ACCTGCAGCACCCGGTGCGCACGCTGCTGCCGGACATGACCGCGCACGCCCTCTACCAGCGCAAATACCGCCAATACCAG
GATTTGATTGAAGCACTACAGGGCTATCACGCCCGTATTAAGGAGCACGCATTATGA

Upstream 100 bases:

>100_bases
CTTCAGCGATGCGCTGGGCAGCCAGGTGCGCGATATGTTCCTGAAAGACAACCCGCAGGGCGCCGATCTCCTGAAAGCCG
TGGACGAGGTGCAATAAGTC

Downstream 100 bases:

>100_bases
GCCGACCATTACTGCAACTGGCGCTCGACCACACCAGTCTGGAAGCAGCCCAACGCGATGTCGCCCTGCTACAGGATCAT
GTCGATATCGTTGAGGCCGG

Product: L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVISKLLAHTGVSGSQIRGLGISA
QGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMATGQYDPRLTEWLGISEIDSALSPVVGSAEICGEITAQAAAITGLAAGTPVVGG
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGDLSF
DEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
DLIEALQGYHARIKEHAL

Sequences:

>Translated_498_residues
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVISKLLAHTGVSGSQIRGLGISA
QGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMATGQYDPRLTEWLGISEIDSALSPVVGSAEICGEITAQAAAITGLAAGTPVVGG
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGDLSF
DEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
DLIEALQGYHARIKEHAL
>Mature_497_residues
SNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVISKLLAHTGVSGSQIRGLGISAQ
GKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGCVMMTHD
YLRWCLTGVKGCEESNISESNLYNMATGQYDPRLTEWLGISEIDSALSPVVGSAEICGEITAQAAAITGLAAGTPVVGGL
FDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGDLSFD
EINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVTG
GPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQD
LIEALQGYHARIKEHAL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=495, Percent_Identity=25.4545454545455, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI164663828, Length=552, Percent_Identity=23.3695652173913, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=85.7429718875502, Blast_Score=898, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=503, Percent_Identity=24.8508946322068, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789987, Length=488, Percent_Identity=24.7950819672131, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790361, Length=465, Percent_Identity=21.7204301075269, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789168, Length=480, Percent_Identity=21.875, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24655555, Length=455, Percent_Identity=24.3956043956044, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24655560, Length=455, Percent_Identity=24.3956043956044, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24655570, Length=455, Percent_Identity=24.3956043956044, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24655574, Length=455, Percent_Identity=24.3956043956044, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24655565, Length=455, Percent_Identity=24.3956043956044, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357867, Length=496, Percent_Identity=23.991935483871, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24656367, Length=484, Percent_Identity=24.7933884297521, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24657106, Length=550, Percent_Identity=23.6363636363636, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24657102, Length=550, Percent_Identity=23.6363636363636, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 54976; Mature: 54845

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVIS
CCCCEEEECCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KLLAHTGVSGSQIRGLGISAQGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQ
HHHHHCCCCCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCH
KLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMATGQYDPRLTEWLGISEIDSALSPVVGSAEICGEITAQAAAITGLAAGTPVVGG
HHCCCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGDLSFDEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEEEHHHHHHH
ALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DLIEALQGYHARIKEHAL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCASVIS
CCCEEEECCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KLLAHTGVSGSQIRGLGISAQGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQ
HHHHHCCCCCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCH
KLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMATGQYDPRLTEWLGISEIDSALSPVVGSAEICGEITAQAAAITGLAAGTPVVGG
HHCCCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGDLSFDEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEEEHHHHHHH
ALHNRAHLLQALYEGVVFSHMTHLNRMRERFTEVCALRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DLIEALQGYHARIKEHAL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]