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The map label for this gene is prlC [H]

Identifier: 16766880

GI number: 16766880

Start: 3763940

End: 3765982

Strand: Reverse

Name: prlC [H]

Synonym: STM3594

Alternate gene names: 16766880

Gene position: 3765982-3763940 (Counterclockwise)

Preceding gene: 16766881

Following gene: 16766879

Centisome position: 77.53

GC content: 55.75

Gene sequence:

>2043_bases
ATGACCAATCCATTACTAACGTCTTTTTCACTGCCGCCTTTTTCTGCAATTAAACCGGAGCATGTGGTGCCTGCGGTCAC
CAAAGCGTTGGCCGATTGCCGGGCGGCGGTAGAAGGCGTTGTGGCGCATGGCGCGCCGTATAGCTGGGAAAACCTCTGCC
AGCCGTTGGCGGAAGCCGACGATGTTCTGGGGCGTATTTTCTCGCCAATTAGCCACTTAAACTCGGTGAAAAATAGTCCG
GAGCTGCGTGAAGCCTACGAACAGACGCTGCCGCTGCTGTCGGAATACAGCACCTGGGTTGGCCAGCATGAAGGGTTGTA
CAACGCGTACCGCGACCTGCGCGACGGCGATCATTACGCCACTCTGAATACCGCGCAGAAGAAAGCGGTTGATAACGCGC
TGCGTGATTTTGAACTGTCCGGCATCGGCCTGCCGAAAGAGAAACAGCAGCGTTACGGCGAAATCGCCACTCGCCTGTCT
GAGCTGGGCAACCAGTACAGCAATAATGTGCTCGATGCCACTATGGGCTGGACGAAGCTCATCACCGATGAAGCCGAGCT
GGCGGGAATGCCGGAAAGCGCTCTGGCGGCAGCTAAAGCCCAGGCGGAAGCCAAAGAGCAGGAAGGTTACCTGCTGACCC
TGGATATCCCGAGCTATCTGCCGGTCATGACCTACTGCGACAACCAGGCGTTGCGCGAAGAGATGTATCGCGCCTATTCC
ACTCGCGCCTCCGATCAGGGGCCGAACGCCGGTAAGTGGGATAACAGCCCGGTGATGGAAGAAATTCTTGCGCTGCGCCA
TGAACTGGCGCAACTGCTGGGCTTCGAAAATTATGCCCATGAATCGCTGGCCACCAAAATGGCGGAAAATCCGCAGCAGG
TGCTCGATTTCTTAACCGATTTGGCGAAACGCGCCCGTCCGCAGGGGGAAAAAGAGCTGGCCCAGCTGCGCGCCTTCGCC
AAAGCCGAATTTGGCGTTGAGGAGCTGCAACCGTGGGATATCGCGTACTACAGTGAAAAGCAAAAACAGCACCTGTACAG
CATCAGCGATGAGCAGCTACGTCCGTACTTCCCGGAAAACAAAGCCGTGAATGGCCTGTTTGAAGTGGTGAAACGTATTT
ACGGCATCACTGCCAAAGAGCGTACTGACGTTGATGTCTGGCACCCGGAAGTGCGTTTCTTTGAACTGTATGACGAAAAT
AACGAGCTGCGCGGCAGCTTCTACCTTGACCTGTACGCGCGCGAACACAAACGCGGCGGGGCGTGGATGGACGACTGTGT
CGGCCAGATGCGTAAAGCGGACGGCACATTGCAAAAGCCGGTCGCTTATCTGACCTGTAATTTCAACCGTCCGGTGAACG
GTAAACCCGCTCTGTTTACCCATGACGAAGTGATCACCCTGTTCCACGAGTTTGGTCATGGCCTGCATCATATGCTGACC
CGCATTGAGACCGCCGGGGTCTCCGGTATCAGCGGCGTGCCGTGGGACGCGGTCGAACTGCCAAGTCAGTTTATGGAAAA
CTGGTGCTGGGAGCCGGAAGCGCTGGCGTTTATCTCCGGCCACTATGAGACCGGCGAACCGCTGCCGAAGGAACTGCTGG
ATAAAATGCTGGCGGCGAAAAACTATCAGGCGGCGCTGTTTATTCTGCGTCAGCTGGAGTTCGGTCTGTTTGATTTCCGT
CTGCATGCGGAATTTAATCCACAGCAAGGAGCGAAAATTCTTGAGACGCTCTTTGAAATTAAAAAACAGGTCGCCGTGGT
GCCGTCACCGACATGGGGTCGCTTTCCACATGCGTTCAGCCATATCTTTGCTGGCGGCTATGCGGCAGGCTACTACAGCT
ATCTGTGGGCCGACGTACTGGCGGCGGACGCTTATTCCCGCTTTGAGGAGGAAGGCATTTTCAACCGTGAGACCGGTCAG
TCGTTCCTTGATAACATCCTGACTCGCGGTGGTTCTGAAGAGCCGATGGAACTCTTTAAACGCTTCCGTGGCCGTGAACC
ACAACTGGACGCGATGCTGGAGCATTACGGGATTAAAGGCTGA

Upstream 100 bases:

>100_bases
TGTCCATCATTGAAATTCCCCTTACTATCCCCCATTCTAGATCTCATCGCGAGAGCGCCAAAAGCGCGCTCCACTCACCT
TCTTCTACAGGACTGCGCAT

Downstream 100 bases:

>100_bases
TTTTACGTGCAAATCTGCTTAATGGATGAAACGGGCGCCACAGACGGCGCCTTATCTGTTCTGGCTGCCCGCTGGGGACT
GGAGCATGACGAAGACAACC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEADDVLGRIFSPISHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLITDEAELAGMPESALAAAKAQAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEN
NELRGSFYLDLYAREHKRGGAWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFNPQQGAKILETLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQ
SFLDNILTRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEADDVLGRIFSPISHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLITDEAELAGMPESALAAAKAQAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEN
NELRGSFYLDLYAREHKRGGAWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFNPQQGAKILETLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQ
SFLDNILTRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG
>Mature_679_residues
TNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEADDVLGRIFSPISHLNSVKNSPE
LREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSE
LGNQYSNNVLDATMGWTKLITDEAELAGMPESALAAAKAQAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYST
RASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAK
AEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDENN
ELRGSFYLDLYAREHKRGGAWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTR
IETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRL
HAEFNPQQGAKILETLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQS
FLDNILTRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=640, Percent_Identity=30.9375, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI14149738, Length=674, Percent_Identity=29.8219584569733, Blast_Score=287, Evalue=3e-77,
Organism=Homo sapiens, GI156105687, Length=619, Percent_Identity=26.9789983844911, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=95.4411764705882, Blast_Score=1325, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=32.3144104803493, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71999758, Length=689, Percent_Identity=24.3831640058055, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32565901, Length=613, Percent_Identity=24.1435562805873, Blast_Score=138, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319793, Length=701, Percent_Identity=29.1012838801712, Blast_Score=300, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6322715, Length=643, Percent_Identity=23.7947122861586, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356111, Length=555, Percent_Identity=30.4504504504505, Blast_Score=259, Evalue=5e-69,
Organism=Drosophila melanogaster, GI20129717, Length=589, Percent_Identity=25.9762308998302, Blast_Score=191, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76944; Mature: 76813

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEAD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPISHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
ITDEAELAGMPESALAAAKAQAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDENNELRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHCCCC
AWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFNPQQGAKILETLFEIKKQVAVVPSPTWGRFPHAFS
CHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQSFLDNILTRGGSEEPMELFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEAD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPISHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
ITDEAELAGMPESALAAAKAQAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDENNELRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHCCCC
AWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFNPQQGAKILETLFEIKKQVAVVPSPTWGRFPHAFS
CHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQSFLDNILTRGGSEEPMELFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]