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The map label for this gene is ptxR [H]

Identifier: 16766218

GI number: 16766218

Start: 3054575

End: 3055507

Strand: Direct

Name: ptxR [H]

Synonym: STM2912

Alternate gene names: 16766218

Gene position: 3054575-3055507 (Clockwise)

Preceding gene: 16766215

Following gene: 16766225

Centisome position: 62.88

GC content: 55.09

Gene sequence:

>933_bases
TTGACAGTAAAGGAGCTCGCCATGCTCAATTTGCAGCGTATGTCGCTGTTTATCGCCGTGGTAGATAGCGGCAGCTTCAC
GGCCGCCGCCGCCGCATCGGGCCAAACAAAAGCGGTAGTGAGTTTTAATATTCGGCAGCTTGAAAAAGAGCTTGGCGTAA
CGTTACTGCTACGTTCCACCCGACGATTGACGCTCACAGACGCCGGCGTCCTCTTTTACCAAAAAGGCGTGAATTTACTC
AACGCAGCGAAAAATTTGCAGGATGAAGTGCGTGCCAGCCATAGTGGGCTGGGCGGCGAGTTACGTATTACCACTACGCC
CGAGTTTGGCGAACAGGTGATCATTCCGTTACTGGCGCAGTTTAGTCAGCGCCATCCCGATCTCCGTATTCGGCATATGT
CCTCATCACATCATGCCGATTTAATTGCCGAGCGCTTTGATGTGGCGATTCGGCTTGGCTCGCTGGCCGACTCCCGCTAT
CGCGCCGCGCTGATATCCCGCTTTACCATTCTGCCGGTCGCCGCGCCGCAGTGGCTCGCCCGCAACCCCGTGTCGTCGCT
GGAGTCGTTGGCTCAGGCGGAATGGATTATTCATGAGCGATTACCTACGCCGCTACGGTGGACAGTAACGAGTAATCATG
GCCAACACTCACGCCTGGAGATAAGCAAAGCCGGCAAAATTTCTGTCGACAGCGCGCGCTCGCTGATGGCCTTCGCTCTC
GCGGGAAGCGGCGTCGCATTACTGCCGCAATGGTTAGTCAACACCGCACTGGAGGATGGAACGTTAATTCACGTGTTACC
CGACTATCATTTTCCCCGTCAGGGCATTTATGCCGTTTACCCGGACGCCCGCCATGTATCGACAAAAGTACGCGCATTTA
TTGATTTTTTACGTTCGCAATGGGATTGCGGGGAGCACGCCCCATCATCGTAG

Upstream 100 bases:

>100_bases
TGCGATACGTCATTATGCATCCTCCGTCAGAGGCGCTAATGTAGCCGTCCGGAGAAAGCCAGATAAGTCCGCGCTTCAAC
GATATACTGTCAAAATAATT

Downstream 100 bases:

>100_bases
CCAGTCCGGGAGCATTGCGCTCCCGGACGGATAATACTGTCTTAATCCTTAACTACCAGCTTGTCTTTGATCCCCTGCGC
CTGCCAACGCACCCACAGCA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTVKELAMLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLL
NAAKNLQDEVRASHSGLGGELRITTTPEFGEQVIIPLLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRY
RAALISRFTILPVAAPQWLARNPVSSLESLAQAEWIIHERLPTPLRWTVTSNHGQHSRLEISKAGKISVDSARSLMAFAL
AGSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSS

Sequences:

>Translated_310_residues
MTVKELAMLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLL
NAAKNLQDEVRASHSGLGGELRITTTPEFGEQVIIPLLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRY
RAALISRFTILPVAAPQWLARNPVSSLESLAQAEWIIHERLPTPLRWTVTSNHGQHSRLEISKAGKISVDSARSLMAFAL
AGSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSS
>Mature_309_residues
TVKELAMLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLLN
AAKNLQDEVRASHSGLGGELRITTTPEFGEQVIIPLLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYR
AALISRFTILPVAAPQWLARNPVSSLESLAQAEWIIHERLPTPLRWTVTSNHGQHSRLEISKAGKISVDSARSLMAFALA
GSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSS

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=31.25, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1789440, Length=286, Percent_Identity=31.4685314685315, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI145693193, Length=294, Percent_Identity=31.2925170068027, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=29.4520547945205, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI87081978, Length=302, Percent_Identity=30.794701986755, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787128, Length=298, Percent_Identity=25.8389261744966, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787589, Length=292, Percent_Identity=28.4246575342466, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788481, Length=297, Percent_Identity=25.9259259259259, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786448, Length=318, Percent_Identity=26.7295597484277, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788706, Length=300, Percent_Identity=24.3333333333333, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786713, Length=275, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789173, Length=284, Percent_Identity=26.4084507042254, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI157672245, Length=146, Percent_Identity=38.3561643835616, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787601, Length=125, Percent_Identity=26.4, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082024, Length=266, Percent_Identity=23.6842105263158, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=26.6129032258064, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34217; Mature: 34085

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKELAMLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRST
CCHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCCCEEEEEHHHHHHHHHHCEEEEEECC
RRLTLTDAGVLFYQKGVNLLNAAKNLQDEVRASHSGLGGELRITTTPEFGEQVIIPLLAQ
CEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
FSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISRFTILPVAAPQWLA
HHHCCCCEEEEECCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHEEECCCCHHHH
RNPVSSLESLAQAEWIIHERLPTPLRWTVTSNHGQHSRLEISKAGKISVDSARSLMAFAL
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCEEHHHHHHHHHHHH
AGSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQ
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHC
WDCGEHAPSS
CCCCCCCCCC
>Mature Secondary Structure 
TVKELAMLNLQRMSLFIAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRST
CHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCCCEEEEEHHHHHHHHHHCEEEEEECC
RRLTLTDAGVLFYQKGVNLLNAAKNLQDEVRASHSGLGGELRITTTPEFGEQVIIPLLAQ
CEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
FSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISRFTILPVAAPQWLA
HHHCCCCEEEEECCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHEEECCCCHHHH
RNPVSSLESLAQAEWIIHERLPTPLRWTVTSNHGQHSRLEISKAGKISVDSARSLMAFAL
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCEEHHHHHHHHHHHH
AGSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQ
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHC
WDCGEHAPSS
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]