| Definition | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome. |
|---|---|
| Accession | NC_003197 |
| Length | 4,857,432 |
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The map label for this gene is sptP [H]
Identifier: 16766184
GI number: 16766184
Start: 3022071
End: 3023702
Strand: Reverse
Name: sptP [H]
Synonym: STM2878
Alternate gene names: 16766184
Gene position: 3023702-3022071 (Counterclockwise)
Preceding gene: 16766185
Following gene: 16766180
Centisome position: 62.25
GC content: 44.12
Gene sequence:
>1632_bases ATGCTAAAGTATGAGGAGAGAAAATTGAATAATTTAACGTTGTCTTCGTTTTCAAAAGTTGGTGTGTCGAATGATGCCCG ACTTTATATTGCTAAGGAAAATACTGATAAGGCATATGTTGCGCCTGAAAAATTTTCGTCAAAAGTATTAACCTGGCTTG GAAAAATGCCGTTATTTAAAAACACTGAAGTGGTGCAAAAACATACGGAAAATATCAGAGTACAGGACCAAAAGATTTTA CAGACATTTCTCCATGCACTAACGGAAAAATATGGGGAAACAGCGGTTAATGACGCACTGTTAATGTCCCGTATAAATAT GAACAAACCCCTTACCCAACGTTTAGCAGTGCAGATCACGGAGTGTGTAAAAGCTGCTGACGAAGGGTTTATAAACCTTA TTAAGAGCAAGGATAATGTTGGTGTCAGGAATGCCGCTTTAGTCATAAAAGGCGGCGATACAAAAGTGGCAGAAAAAAAT AACGATGTTGGAGCAGAAAGTAAGCAACCTTTACTCGATATCGCGCTAAAGGGACTTAAAAGAACATTACCGCAACTGGA ACAAATGGATGGAAATAGCCTGCGAGAAAACTTCCAGGAGATGGCTTCAGGTAACGGCCCGCTGCGTTCATTAATGACGA ATTTACAGAATTTAAATAAAATTCCAGAGGCTAAACAACTTAATGATTATGTTACAACGTTAACAAATATTCAGGTCGGT GTAGCCCGGTTCTCACAATGGGGAACCTGTGGAGGAGAGGTTGAGAGGTGGGTTGATAAAGCCTCTACTCATGAATTAAC CCAGGCTGTAAAAAAAATTCACGTTATTGCTAAAGAACTGAAAAATGTTACAGCTGAACTTGAGAAAATAGAAGCCGGCG CGCCAATGCCACAGACGATGAGCGGACCGACACTGGGCCTGGCACGATTTGCGGTCAGCAGCATTCCAATTAATCAGCAA ACCCAGGTGAAACTGAGCGATGGAATGCCTGTGCCAGTGAATACGTTAACTTTTGACGGTAAGCCTGTGGCATTAGCCGG TTCGTACCCAAAAAATACGCCGGATGCGCTGGAAGCGCATATGAAAATGCTTCTTGAAAAAGAATGCTCGTGCCTGGTGG TGTTAACGTCGGAAGATCAGATGCAGGCAAAACAATTACCACCCTATTTCAGAGGGAGCTACACCTTTGGCGAGGTGCAT ACCAACAGCCAAAAAGTGAGCTCAGCCAGTCAGGGAGAAGCGATAGACCAATACAATATGCAACTGTCCTGCGGGGAAAA GCGGTATACAATCCCGGTATTGCATGTGAAAAATTGGCCAGATCACCAGCCGTTACCGTCTACGGATCAGTTAGAATACC TGGCGGATAGGGTGAAAAATAGTAACCAAAATGGCGCGCCGGGGCGTAGTTCATCAGATAAGCATTTACCGATGATTCAT TGTCTGGGCGGAGTGGGAAGAACCGGAACGATGGCGGCGGCCCTTGTACTTAAGGATAATCCTCATAGTAATCTGGAGCA GGTACGTGCAGATTTCCGGGATTCACGGAACAATAGAATGCTGGAAGACGCCTCACAGTTTGTACAACTAAAAGCAATGC AAGCCCAGTTGCTTATGACGACGGCAAGCTGA
Upstream 100 bases:
>100_bases ATACATGCAATTACCGATCTGACAAATACTTACCATATTATATCGCAGCTTGAGTCATTTGTGAATCAGCAGGAAGCGCT CAAAAACATACTGCAGGAAT
Downstream 100 bases:
>100_bases TAAAAACATAGCTTACTTTTAGAACTATCTGAAAGTAAGCTATTTCTGTATAATTATTTGTTTGCCGCGATAGAAAGTCT TTTGTTTTTCTCTTCTGCTG
Product: protein tyrosine phosphatase/GTPase activating protein
Products: NA
Alternate protein names: GTPase-activating protein; GAP; Tyrosine-protein phosphatase [H]
Number of amino acids: Translated: 543; Mature: 543
Protein sequence:
>543_residues MLKYEERKLNNLTLSSFSKVGVSNDARLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFKNTEVVQKHTENIRVQDQKIL QTFLHALTEKYGETAVNDALLMSRINMNKPLTQRLAVQITECVKAADEGFINLIKSKDNVGVRNAALVIKGGDTKVAEKN NDVGAESKQPLLDIALKGLKRTLPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQNLNKIPEAKQLNDYVTTLTNIQVG VARFSQWGTCGGEVERWVDKASTHELTQAVKKIHVIAKELKNVTAELEKIEAGAPMPQTMSGPTLGLARFAVSSIPINQQ TQVKLSDGMPVPVNTLTFDGKPVALAGSYPKNTPDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPPYFRGSYTFGEVH TNSQKVSSASQGEAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRDSRNNRMLEDASQFVQLKAMQAQLLMTTAS
Sequences:
>Translated_543_residues MLKYEERKLNNLTLSSFSKVGVSNDARLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFKNTEVVQKHTENIRVQDQKIL QTFLHALTEKYGETAVNDALLMSRINMNKPLTQRLAVQITECVKAADEGFINLIKSKDNVGVRNAALVIKGGDTKVAEKN NDVGAESKQPLLDIALKGLKRTLPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQNLNKIPEAKQLNDYVTTLTNIQVG VARFSQWGTCGGEVERWVDKASTHELTQAVKKIHVIAKELKNVTAELEKIEAGAPMPQTMSGPTLGLARFAVSSIPINQQ TQVKLSDGMPVPVNTLTFDGKPVALAGSYPKNTPDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPPYFRGSYTFGEVH TNSQKVSSASQGEAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRDSRNNRMLEDASQFVQLKAMQAQLLMTTAS >Mature_543_residues MLKYEERKLNNLTLSSFSKVGVSNDARLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFKNTEVVQKHTENIRVQDQKIL QTFLHALTEKYGETAVNDALLMSRINMNKPLTQRLAVQITECVKAADEGFINLIKSKDNVGVRNAALVIKGGDTKVAEKN NDVGAESKQPLLDIALKGLKRTLPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQNLNKIPEAKQLNDYVTTLTNIQVG VARFSQWGTCGGEVERWVDKASTHELTQAVKKIHVIAKELKNVTAELEKIEAGAPMPQTMSGPTLGLARFAVSSIPINQQ TQVKLSDGMPVPVNTLTFDGKPVALAGSYPKNTPDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPPYFRGSYTFGEVH TNSQKVSSASQGEAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRDSRNNRMLEDASQFVQLKAMQAQLLMTTAS
Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal
COG id: NA
COG function: NA
Gene ontology:
Cell location: Secreted. Host cytoplasm (By similarity). Note=Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cytoplasm (By similarity) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Contains 1 tyrosine-protein phosphatase domain [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000387 - InterPro: IPR011070 - InterPro: IPR015203 - InterPro: IPR016130 - InterPro: IPR003546 - InterPro: IPR000242 - InterPro: IPR014773 [H]
Pfam domain/function: PF09119 SicP-binding; PF00102 Y_phosphatase; PF03545 YopE [H]
EC number: =3.1.3.48 [H]
Molecular weight: Translated: 60048; Mature: 60048
Theoretical pI: Translated: 8.88; Mature: 8.88
Prosite motif: PS00383 TYR_PHOSPHATASE_1 ; PS50056 TYR_PHOSPHATASE_2 ; PS50055 TYR_PHOSPHATASE_PTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 3.5 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 3.5 %Met (Mature Protein) 4.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLKYEERKLNNLTLSSFSKVGVSNDARLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFK CCCCHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHCCCCCC NTEVVQKHTENIRVQDQKILQTFLHALTEKYGETAVNDALLMSRINMNKPLTQRLAVQIT CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHH ECVKAADEGFINLIKSKDNVGVRNAALVIKGGDTKVAEKNNDVGAESKQPLLDIALKGLK HHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHH RTLPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQNLNKIPEAKQLNDYVTTLTNIQVG HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH VARFSQWGTCGGEVERWVDKASTHELTQAVKKIHVIAKELKNVTAELEKIEAGAPMPQTM HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC SGPTLGLARFAVSSIPINQQTQVKLSDGMPVPVNTLTFDGKPVALAGSYPKNTPDALEAH CCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHH MKMLLEKECSCLVVLTSEDQMQAKQLPPYFRGSYTFGEVHTNSQKVSSASQGEAIDQYNM HHHHHHCCCCEEEEECCCCHHHHHHCCCCCCCCCEECEEECCHHHHCCCCCCCCHHHCCC QLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH EEECCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRDSRNNRMLEDASQFVQLKAMQAQLLMT HHCCCCCCCHHEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEE TAS ECC >Mature Secondary Structure MLKYEERKLNNLTLSSFSKVGVSNDARLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFK CCCCHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHCCCCCC NTEVVQKHTENIRVQDQKILQTFLHALTEKYGETAVNDALLMSRINMNKPLTQRLAVQIT CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHH ECVKAADEGFINLIKSKDNVGVRNAALVIKGGDTKVAEKNNDVGAESKQPLLDIALKGLK HHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHH RTLPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQNLNKIPEAKQLNDYVTTLTNIQVG HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH VARFSQWGTCGGEVERWVDKASTHELTQAVKKIHVIAKELKNVTAELEKIEAGAPMPQTM HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC SGPTLGLARFAVSSIPINQQTQVKLSDGMPVPVNTLTFDGKPVALAGSYPKNTPDALEAH CCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHH MKMLLEKECSCLVVLTSEDQMQAKQLPPYFRGSYTFGEVHTNSQKVSSASQGEAIDQYNM HHHHHHCCCCEEEEECCCCHHHHHHCCCCCCCCCEECEEECCHHHHCCCCCCCCHHHCCC QLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH EEECCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRDSRNNRMLEDASQFVQLKAMQAQLLMT HHCCCCCCCHHEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEE TAS ECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA