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The map label for this gene is gabP [H]

Identifier: 16766104

GI number: 16766104

Start: 2943010

End: 2944410

Strand: Direct

Name: gabP [H]

Synonym: STM2793

Alternate gene names: 16766104

Gene position: 2943010-2944410 (Clockwise)

Preceding gene: 16766103

Following gene: 16766105

Centisome position: 60.59

GC content: 51.39

Gene sequence:

>1401_bases
ATGGGGCAATTGTCAGAATCACATGCATTAGGGGGCGGGCTGAAATCACGCCACGTCACCATGTTATCGATCGCCGGCGT
CATCGGCGCCAGCCTGTTTGTCGGTTCCAGCGTGGCGATTGCGGAGGCCGGCCCTGCGGTACTGCTGGCCTATCTGTTCG
CAGGACTTTTAGTCGTCATGATTATGCGAATGCTGGCTGAAATGGCCGTCGCCACACCGGATACCGGATCTTTTTCCACC
TATGCGGATAAAGCGATCGGCCCCTGGGCCGGGTATACCATCGGCTGGTTATACTGGTGGTTTTGGGTGCTGGTTATTCC
GCTGGAGGCCAATATTGCCGCCATTATTCTGAATTCATGGATACCGGGTATTCCGGTATGGCTATTTTCATTAGTGATTA
CGCTTGCCTTAACCGGAAGCAATTTATTGAGCGTCAAAAATTACGGCGAGTTCGAATTCTGGCTGGCGCTATGTAAAGTA
ATTGCCATTCTGGCGTTTATCGCGCTGGGCGCGACGGCGATTAGCGGTTTTTATCCGTATGCTGAGGTAAGCGGTATCTC
CCGGCTCTGGGATCACGGCGGTTTTATGCCTAACGGCTTCGGCGCGGTGTTAAGCGCCATGTTGATCACCATGTTCTCTT
TTATGGGCGCGGAAATCGTTACTATTGCTGCCGCGGAATCCGATACGCCGGATAAACATATCGTACGCGCCACCAATTCT
GTTATCTGGCGAATTTCCATCTTTTACCTGTGTTCCATTTTTGTGGTGGTGGCGCTGATCCCGTGGAATATGCCGGGTCT
GAAAAGCGTAGGTTCGTACCGTTCGGTACTGGAGCTGCTTCATATTCCGCACGCAAAATTCATTATGGACTGCGTGATTT
TATTGTCGGTGACCAGTTGTCTGAACTCCGCATTATATACCGCCTCCCGGATGCTCTATTCCCTTAGCCGCCGCGGCGAT
GCTCCTGCGATAATGGGAAAAACTAACCGTAGCAAAACGCCCTGGGTAGCGGTTCTCCTCTCTACCGGCGCGGCCTTTTT
AACCGTTATCGTCAATTATTACGCCCCGGCAAAAGTGTTTAAATTTCTTATCGACAGTTCCGGCGCCATCGCGCTGCTGG
TCTATCTGGTGATTGCGATTTCGCAATTGCGAATGCGTAAAATTCTGCTGGCGCAGGGCGGAGAAATTAAGCTGAAAATG
TGGCTTTATCCGTGGCTCACCTGGCTGGTTATCGGCTTTATCTGCTTTGTCCTGGTGGTGATGCTATTTCGACCGGCACA
GCAACTAGAAGTCATTTCAACGGGGCTGTTAGGGCTGGGCATAATAGGTACTGTCCCCATTATGTCTCGCTGGAAAAAAC
TGATAAGGTGGCAAAAAGCCCCCCTGCAAAACCTACGTTAG

Upstream 100 bases:

>100_bases
TAACTGTCTTATCCGGCCTACAAAAACCGTTTCGATTGTAGGCCGAATAAGCCAGGCGCCATCCGGTAAACGAGCGCAAT
AACAATAAAGAGGTTTTAGG

Downstream 100 bases:

>100_bases
TTATTCCCGGCGTCAGCCGGGAAGCTTCTCAGGAGTAAAAGATGACCGCCCTTTCCCAACCGACGGCCATAGATGGCTAT
CGCTGGCTTAAAAATGACAT

Product: gamma-aminobutyrate transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSWIPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIALGATAISGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APAIMGKTNRSKTPWVAVLLSTGAAFLTVIVNYYAPAKVFKFLIDSSGAIALLVYLVIAISQLRMRKILLAQGGEIKLKM
WLYPWLTWLVIGFICFVLVVMLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR

Sequences:

>Translated_466_residues
MGQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSWIPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIALGATAISGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APAIMGKTNRSKTPWVAVLLSTGAAFLTVIVNYYAPAKVFKFLIDSSGAIALLVYLVIAISQLRMRKILLAQGGEIKLKM
WLYPWLTWLVIGFICFVLVVMLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR
>Mature_465_residues
GQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFSTY
ADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSWIPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVI
AILAFIALGATAISGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNSV
IWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSCLNSALYTASRMLYSLSRRGDA
PAIMGKTNRSKTPWVAVLLSTGAAFLTVIVNYYAPAKVFKFLIDSSGAIALLVYLVIAISQLRMRKILLAQGGEIKLKMW
LYPWLTWLVIGFICFVLVVMLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=466, Percent_Identity=92.0600858369099, Blast_Score=861, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=437, Percent_Identity=35.9267734553776, Blast_Score=274, Evalue=9e-75,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=36.8298368298368, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI87081708, Length=436, Percent_Identity=36.4678899082569, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI48994972, Length=423, Percent_Identity=34.7517730496454, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788480, Length=403, Percent_Identity=34.7394540942928, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1786602, Length=433, Percent_Identity=34.6420323325635, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI87081915, Length=399, Percent_Identity=32.0802005012531, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1790653, Length=448, Percent_Identity=30.3571428571429, Blast_Score=224, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17532491, Length=364, Percent_Identity=23.0769230769231, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=436, Percent_Identity=31.1926605504587, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=439, Percent_Identity=28.7015945330296, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=439, Percent_Identity=29.8405466970387, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=31.9095477386935, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324990, Length=422, Percent_Identity=31.9905213270142, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322892, Length=395, Percent_Identity=32.9113924050633, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324924, Length=455, Percent_Identity=27.6923076923077, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320717, Length=429, Percent_Identity=28.4382284382284, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321053, Length=401, Percent_Identity=27.6807980049875, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6319824, Length=441, Percent_Identity=27.437641723356, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=440, Percent_Identity=26.3636363636364, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=399, Percent_Identity=28.0701754385965, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=394, Percent_Identity=26.3959390862944, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=417, Percent_Identity=26.8585131894484, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=27.0935960591133, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324981, Length=395, Percent_Identity=29.1139240506329, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=421, Percent_Identity=26.1282660332542, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320364, Length=468, Percent_Identity=23.0769230769231, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667468, Length=400, Percent_Identity=22.5, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50900; Mature: 50768

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSW
HHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
IPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIALGATAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAIMGKTNRSKTPWVAVLLSTGAAFLTVIVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAISQLRMRKILLAQGGEIKLKMWLYPWLTWLVIGFICFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure 
GQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSW
HHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
IPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIALGATAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAIMGKTNRSKTPWVAVLLSTGAAFLTVIVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAISQLRMRKILLAQGGEIKLKMWLYPWLTWLVIGFICFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]