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The map label for this gene is kgtP [H]

Identifier: 16765974

GI number: 16765974

Start: 2794375

End: 2795676

Strand: Reverse

Name: kgtP [H]

Synonym: STM2654

Alternate gene names: 16765974

Gene position: 2795676-2794375 (Counterclockwise)

Preceding gene: 16765975

Following gene: 16765968

Centisome position: 57.55

GC content: 51.77

Gene sequence:

>1302_bases
ATGGCAGAAATTATTCAGCGTATAGATAAAAACAACGCTGAGGCTCCGGAGATGCGGCGACGCATATGGGCTATCGTGGG
GGCCTCTTCCGGAAACTTAGTGGAATGGTTTGATTTCTACGTCTACTCTTTCTGCTCGCTCTATTTTGCACATATCTTCT
TTCCTTCTGGTAATACCACTACTCAGCTTTTGCAAACGGCAGGCGTCTTTGCCGCCGGTTTTTTAATGCGGCCTATCGGT
GGTTGGCTATTTGGACGCATTGCAGATCGACGCGGGCGCAAAGCCTCAATGTTGATTTCGGTGTGCATGATGTGCATGGG
GTCGCTGGTGATTGCCTGCTTACCTGGTTACGATACCATCGGCACCTGGGCACCGGCGCTGCTACTTATTGCAAGGTTAT
TTCAGGGGCTCTCGGTAGGGGGAGAGTATGGGACCAGCGCGACATATATGAGTGAAGTTGCGCTTGAAGGTCGTAAGGGA
TTTTTCGCGTCGTTTCAGTACGTTACGCTTATCGGTGGCCAACTACTGGCATTGCTGGTCGTTGTGATTTTGCAGCAGGT
TCTGGACGATGCTGAGCTTCGTGCCTGGGGATGGCGTATTCCCTTTGCGCTGGGCGCCGTGCTGGCGGTTGTGGCGTTAT
GGCTACGTCGCCAGCTGGATGAAACCTCGAAGCATGAGACTCGCGCATTAAAAGAAGCCGGTTCGTTGAAAGGTTTGTGG
CGTAATCGCAAAGCCTTTTTGATGGTGCTTGGTTTCACCGCGGCAGGCTCGCTGTGCTTTTATACCTTCACCACCTATAT
GCAGAAATATCTGGTAAATACAGCAGGTATGCATGCCAATGTCGCCAGCGGCATTATGACGGCTGCGCTGTGTGTTTTCA
TGTTGGTGCAGCCGTTATTCGGCGCGTTATCCGATAAGATTGGCAGGCGCACCTCTATGCTATGTTTTGGCGCACTCGCG
ACGCTTTTCACCGTTCCAATTCTCTCCGCGTTGCAGAATGTGACGTCGCCTTATGCCGCATTTGCTTTAGTGATATGCGC
GCTATTGATTGTGAGTTTCTATACCTCGATTAGCGGGATCCTGAAAGCGGAGATGTTTCCGGCGCAGGTTCGCGCCCTGG
GCGTCGGTTTATCTTACGCGGTAGCAAACGCGTTATTTGGCGGCTCTGCGGAATATGTCGCGCTGTCGCTAAAATCTGTC
GGTATGGAGAGTTCGTTCTTCTGGTATGTTACCGCGATGGCCGTTCTGGCTTTCCTGGTTTCGTTGATGTTGCACCGTAA
AGGAAAGGGCTTACGCCTTTAG

Upstream 100 bases:

>100_bases
TTAGCAAACAAATAATTAACACTTTATTTACTTTTGGGTCTCGCGTAATCTGAATCTCCAAAATAAAAGGCCGATTAAGC
CTGGCAACAAGGAGAACAGT

Downstream 100 bases:

>100_bases
TATCGCGCCATTTGCCAGATAGCGTAACCGGTTGTCGCGCCAGCGACATCCCAGACAAAATCTTTCCAGCTCCAGCCGCT
GCCTTCCGGGCGGCTGTCCC

Product: alpha-ketoglutarate transporter

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MAEIIQRIDKNNAEAPEMRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIG
GWLFGRIADRRGRKASMLISVCMMCMGSLVIACLPGYDTIGTWAPALLLIARLFQGLSVGGEYGTSATYMSEVALEGRKG
FFASFQYVTLIGGQLLALLVVVILQQVLDDAELRAWGWRIPFALGAVLAVVALWLRRQLDETSKHETRALKEAGSLKGLW
RNRKAFLMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALCVFMLVQPLFGALSDKIGRRTSMLCFGALA
TLFTVPILSALQNVTSPYAAFALVICALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSV
GMESSFFWYVTAMAVLAFLVSLMLHRKGKGLRL

Sequences:

>Translated_433_residues
MAEIIQRIDKNNAEAPEMRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIG
GWLFGRIADRRGRKASMLISVCMMCMGSLVIACLPGYDTIGTWAPALLLIARLFQGLSVGGEYGTSATYMSEVALEGRKG
FFASFQYVTLIGGQLLALLVVVILQQVLDDAELRAWGWRIPFALGAVLAVVALWLRRQLDETSKHETRALKEAGSLKGLW
RNRKAFLMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALCVFMLVQPLFGALSDKIGRRTSMLCFGALA
TLFTVPILSALQNVTSPYAAFALVICALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSV
GMESSFFWYVTAMAVLAFLVSLMLHRKGKGLRL
>Mature_432_residues
AEIIQRIDKNNAEAPEMRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGG
WLFGRIADRRGRKASMLISVCMMCMGSLVIACLPGYDTIGTWAPALLLIARLFQGLSVGGEYGTSATYMSEVALEGRKGF
FASFQYVTLIGGQLLALLVVVILQQVLDDAELRAWGWRIPFALGAVLAVVALWLRRQLDETSKHETRALKEAGSLKGLWR
NRKAFLMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALCVFMLVQPLFGALSDKIGRRTSMLCFGALAT
LFTVPILSALQNVTSPYAAFALVICALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSVG
MESSFFWYVTAMAVLAFLVSLMLHRKGKGLRL

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=433, Percent_Identity=88.4526558891455, Blast_Score=745, Evalue=0.0,
Organism=Escherichia coli, GI1790550, Length=362, Percent_Identity=33.7016574585635, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1788292, Length=403, Percent_Identity=31.2655086848635, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1789941, Length=427, Percent_Identity=32.5526932084309, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082231, Length=223, Percent_Identity=31.390134529148, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082404, Length=375, Percent_Identity=23.7333333333333, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 47234; Mature: 47103

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCCCCC
>Mature Secondary Structure 
AEIIQRIDKNNAEAPEMRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTT
HHHHHHHCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH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HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]