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The map label for this gene is panE [C]

Identifier: 16765893

GI number: 16765893

Start: 2718475

End: 2719392

Strand: Reverse

Name: panE [C]

Synonym: STM2573

Alternate gene names: 16765893

Gene position: 2719392-2718475 (Counterclockwise)

Preceding gene: 16765894

Following gene: 16765891

Centisome position: 55.98

GC content: 48.91

Gene sequence:

>918_bases
ATGAAAATTGCAATCGCAGGTGCAGGCGCTATGGGATGTCGTTTTGGCTATATGCTGCTGGAGGCCGGGCACGACGTGAC
GCTTATTGATGGCTGGCAGGAGCATGTCGACGCTATTCGTAGCAAGGGGTTGTTTGTCGAAACGGAAACGACTCAGAAGT
ATTACCCCATCCCTGCTATGTTGGCTGATGAATCCCAGGGGGAGTTTGAGCTGGTTATTCTGTTTACCAAAGCCATGCAG
TTGGATAGCATGTTACAGCGTATTAAGCCGCTGCTGCCAGCCGCGAAGGTCGTGATGATTTTATCTAACGGCCTGGGAAA
TATCGAAACCCTGGAGAAATATGTCGATCGGCAGAAAATCTATGCGGGTGTGACGTTATGGTCCAGCGAACTGGAGGGGG
CTGGGCATATTATGGCCACCGGTACCGGAACGATTGAACTGCAGCCGATAGCCAGCCAGGATTCGGCTCAAGAGGCTAAG
GTCATTGCCACCCTTAATAGTGCTGGATTGAATGCTGAAATAAGCCCTGACGTATTATTATCGATCTGGAAGAAAGCAGC
CTTTAATAGCGTAATGAACACCTATTGCGCGTTACTGGATTGTAATGTCGGCGGATTTGGTCAGCGGCCTGGTGCTTTAG
ATTTAGCGCAAGCGGTAGTTGATGAGTTTGTGTTAGTTGCTGCCAGCCAGAATATTCCGTTGACTGAGCAAATGGTGATG
AATACGGTGAAGAAAGTGTTCGATCCGCGTGAGAGCGGCCACCACTATCCTTCTATGCATCAGGATTTACATAAAGGCCG
ACTGACCGAAATCGACTATTTAAATGGTGCGATTGCGCGAATCGGCGCTCAGAACAATATTGCCGTACCGGTTAACAAAC
TCCTGACGCAATTGATTCACGCTAAAGAAGCGCAATAA

Upstream 100 bases:

>100_bases
GGTGCTATTGCTTATTGGAGTCGTGTTGACCCTGATAACGAAAAAATATGTCGCAACGGTTTTAGCCAAAATTCATTAAT
CAGATAATAAGGAAATAAAA

Downstream 100 bases:

>100_bases
ACTTGATAGCTCTTCTGCATGAGGCGGAAGAGCCATTTTCAAACCAGTTTTTTTACCAGCGCCTCGCTATGGCGAATACG
CTCCGGCGCCCGCTCTAAAT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIHAKEAQ

Sequences:

>Translated_305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIHAKEAQ
>Mature_305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIHAKEAQ

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=312, Percent_Identity=25.3205128205128, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320057, Length=201, Percent_Identity=29.3532338308458, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33151; Mature: 33151

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAM
CEEEEECCCHHHHHHHHHHEECCCCEEEECCHHHHHHHHHHCCCEEEECCCCEECCCCCE
LADESQGEFELVILFTKAMQLDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKI
ECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAKVIATLNSAGLNAEISPDVLL
HHHHEEECCCCCCCCEEEEECCCEEEEEECCCCCCCHHCEEEEEECCCCCCCCCCHHHHH
SIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHH
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIH
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEHHHCCHHHHHCCCCCEECCHHHHHHHHHH
AKEAQ
HCCCC
>Mature Secondary Structure
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAM
CEEEEECCCHHHHHHHHHHEECCCCEEEECCHHHHHHHHHHCCCEEEECCCCEECCCCCE
LADESQGEFELVILFTKAMQLDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKI
ECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAKVIATLNSAGLNAEISPDVLL
HHHHEEECCCCCCCCEEEEECCCEEEEEECCCCCCCHHCEEEEEECCCCCCCCCCHHHHH
SIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHH
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIH
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEHHHCCHHHHHCCCCCEECCHHHHHHHHHH
AKEAQ
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]