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The map label for this gene is yfhK [H]

Identifier: 16765884

GI number: 16765884

Start: 2706174

End: 2707616

Strand: Reverse

Name: yfhK [H]

Synonym: STM2564

Alternate gene names: 16765884

Gene position: 2707616-2706174 (Counterclockwise)

Preceding gene: 16765885

Following gene: 16765883

Centisome position: 55.74

GC content: 55.16

Gene sequence:

>1443_bases
GTGAGCGACACGTTGAAGCGCTGGTCTGTTTTCCCCCGTTCTTTACGACAATTGGTCATGCTGGCCTTTTTGCTGATCCT
GCTGCCGTTGCTGGTTCTGGCCTGGCAGGCGTGGCAAAGCCTTAACGCGTTAAGCGATCAGGCTGCGGTGACTAACCGCA
GCACGCTTATTGACGCCCGGCGCAGCGAGGCGATGACCAACGTCGCGCTGGAGATGGAGCGAAGCTACCGACAGTATTGC
GTGCTTGACGATCCGACGCTGGCAAAAGTGTATCAAAGCCAGCGTAAGCGCTATAGCGATATGCTGGACGCCCATGCCGG
CGTCTTGCCGGATGATAAGTTGTATCAGGCGTTACGCCAGGATTTAAACGCGCTGGCGCAATTGCAGTGTAAAGATAGCG
GCCCGGAAGCGGCAGCGGCCGCGCGCCTGGAGGCCTTTGCCAACGCGAATACGGAAATGGTGCAGGCGACGCGTACCGTG
GTTTACTCGCGCGGGCAGCAGTTACAACAAGAAATCGCCGAGCGCGGACAATTTTTCGGCTGGCAGGCGCTGGTGCTATT
TCTGGTGAGCCTGGCGATGGTGCTACTTTTTACCCGCATGATTATCGGGCCGGTGAAAGGAATTGAACGGATGATTAATC
GCCTGGGCGAAGGCCGTTCTTTGGGGAATACCGTCACCTTTACCGGTCCGCGTGAATTACGATCGGTGGGGCAGCGCATT
ATCTGGCTGAGTGAGCGTCTGGCGTGGCTGGAATCCCAGCGCCATCAGTTTCTACGTCACCTGTCCCATGAGCTGAAAAC
CCCGCTGGCCAGTATGCGCGAGGGGACTGAGCTGCTGGCCGATCAGGTGGTTGGGCCGCTGACGCCGGAGCAAAAAGAGG
TGGTCGATATTCTGGATGACAGCAGTCGTAATTTACAAAAATTGATTGAGCAATTGCTTGATTACAACCGGAAACTGGTA
GACAGTGCCACAGAGCTGGAAGCGGTCGATATCGCGCCGCTTGTGGATATGGTGGTTTCCGCCCACAGTTTGCCTGCCCG
CGCTAAAATGATGCATACCGATGTCGACCTGGAGGCCGAACGCTGCATAGCAGAGCCCATGTTGCTGATGAGCGTGCTGG
ATAATCTCTATTCCAACGCGGTGCACTATGGCGCTGAATCCGGTAACATTTGTATCCGTAGTCGCTCTCAGGGCTCCACG
GTTTATATCGATGTGGTTAATAGCGGCGAGCCGATTCCGCAAACCGAAAGAGAAATGATTTTTGAGCCTTTTTTCCAGGG
AAGCCACCAGCGAAAAGGGGCGGTAAAAGGCAGTGGGTTAGGGCTGAGTATCGCCAGAGATTGTATTCGTCGAATGCAGG
GAGAGATCCAACTGGTGGATGACAACGCGCAGGAAGTTTGTTTTCGCATCTCGCTGCCATTGCCTGCATCTGACAAACAC
TAA

Upstream 100 bases:

>100_bases
GAGTTAGGCACCGCCTTATTCCATAACAAAGCCGGGTTTAGCCCGGCTTTGTTGTATCTGGCGCTTCCCTCGGTTAGCAT
CTTTTTTATTCTTCTTTTAT

Downstream 100 bases:

>100_bases
TATGAATTTAAGCCTGGTGCGTATGTCACACGTTTTCGTCCAAACTATTAAACGATGCCTTTTGCGGTGGGGAATACCGG
TGGGCATATCGTGTCTGGCG

Product: sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSDTLKRWSVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAAVTNRSTLIDARRSEAMTNVALEMERSYRQYC
VLDDPTLAKVYQSQRKRYSDMLDAHAGVLPDDKLYQALRQDLNALAQLQCKDSGPEAAAAARLEAFANANTEMVQATRTV
VYSRGQQLQQEIAERGQFFGWQALVLFLVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTFTGPRELRSVGQRI
IWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVDILDDSSRNLQKLIEQLLDYNRKLV
DSATELEAVDIAPLVDMVVSAHSLPARAKMMHTDVDLEAERCIAEPMLLMSVLDNLYSNAVHYGAESGNICIRSRSQGST
VYIDVVNSGEPIPQTEREMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEVCFRISLPLPASDKH

Sequences:

>Translated_480_residues
MSDTLKRWSVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAAVTNRSTLIDARRSEAMTNVALEMERSYRQYC
VLDDPTLAKVYQSQRKRYSDMLDAHAGVLPDDKLYQALRQDLNALAQLQCKDSGPEAAAAARLEAFANANTEMVQATRTV
VYSRGQQLQQEIAERGQFFGWQALVLFLVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTFTGPRELRSVGQRI
IWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVDILDDSSRNLQKLIEQLLDYNRKLV
DSATELEAVDIAPLVDMVVSAHSLPARAKMMHTDVDLEAERCIAEPMLLMSVLDNLYSNAVHYGAESGNICIRSRSQGST
VYIDVVNSGEPIPQTEREMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEVCFRISLPLPASDKH
>Mature_479_residues
SDTLKRWSVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAAVTNRSTLIDARRSEAMTNVALEMERSYRQYCV
LDDPTLAKVYQSQRKRYSDMLDAHAGVLPDDKLYQALRQDLNALAQLQCKDSGPEAAAAARLEAFANANTEMVQATRTVV
YSRGQQLQQEIAERGQFFGWQALVLFLVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTFTGPRELRSVGQRII
WLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVDILDDSSRNLQKLIEQLLDYNRKLVD
SATELEAVDIAPLVDMVVSAHSLPARAKMMHTDVDLEAERCIAEPMLLMSVLDNLYSNAVHYGAESGNICIRSRSQGSTV
YIDVVNSGEPIPQTEREMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEVCFRISLPLPASDKH

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=475, Percent_Identity=86.9473684210526, Blast_Score=810, Evalue=0.0,
Organism=Escherichia coli, GI1790861, Length=250, Percent_Identity=33.2, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=29.646017699115, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789808, Length=294, Percent_Identity=23.1292517006803, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=29.6943231441048, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=26.4285714285714, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=25.2252252252252, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790346, Length=293, Percent_Identity=24.5733788395904, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=24.4224422442244, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI48994928, Length=228, Percent_Identity=26.7543859649123, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789149, Length=216, Percent_Identity=27.3148148148148, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=28.099173553719, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=262, Percent_Identity=27.4809160305344, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790300, Length=215, Percent_Identity=30.2325581395349, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=24.8908296943231, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787894, Length=298, Percent_Identity=25.503355704698, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=250, Percent_Identity=26.8, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53918; Mature: 53787

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLKRWSVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAAVTNRSTLIDAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RSEAMTNVALEMERSYRQYCVLDDPTLAKVYQSQRKRYSDMLDAHAGVLPDDKLYQALRQ
HHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
DLNALAQLQCKDSGPEAAAAARLEAFANANTEMVQATRTVVYSRGQQLQQEIAERGQFFG
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WQALVLFLVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTFTGPRELRSVGQRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHH
IWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVDILDD
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
SSRNLQKLIEQLLDYNRKLVDSATELEAVDIAPLVDMVVSAHSLPARAKMMHTDVDLEAE
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHH
RCIAEPMLLMSVLDNLYSNAVHYGAESGNICIRSRSQGSTVYIDVVNSGEPIPQTEREMI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHH
FEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEVCFRISLPLPASDKH
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHEEEEEECCCCCCCCC
>Mature Secondary Structure 
SDTLKRWSVFPRSLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAAVTNRSTLIDAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RSEAMTNVALEMERSYRQYCVLDDPTLAKVYQSQRKRYSDMLDAHAGVLPDDKLYQALRQ
HHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
DLNALAQLQCKDSGPEAAAAARLEAFANANTEMVQATRTVVYSRGQQLQQEIAERGQFFG
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WQALVLFLVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTFTGPRELRSVGQRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHH
IWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVDILDD
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
SSRNLQKLIEQLLDYNRKLVDSATELEAVDIAPLVDMVVSAHSLPARAKMMHTDVDLEAE
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHH
RCIAEPMLLMSVLDNLYSNAVHYGAESGNICIRSRSQGSTVYIDVVNSGEPIPQTEREMI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHH
FEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEVCFRISLPLPASDKH
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]