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The map label for this gene is mntH

Identifier: 16765734

GI number: 16765734

Start: 2523719

End: 2524960

Strand: Reverse

Name: mntH

Synonym: STM2408

Alternate gene names: 16765734

Gene position: 2524960-2523719 (Counterclockwise)

Preceding gene: 16765736

Following gene: 16765731

Centisome position: 51.98

GC content: 54.83

Gene sequence:

>1242_bases
ATGACTGACAATCGCGTAGAGAATAGCAGCGGACGGGCGGCGCGCAAGCTAAGGCTCGCATTAATGGGACCTGCGTTCAT
TGCCGCGATTGGTTATATCGATCCTGGTAACTTCGCGACCAATATTCAGGCCGGCGCCAGCTTTGGCTATCAGCTACTCT
GGGTGGTGGTCTGGGCGAACCTGATGGCGATGCTGATTCAAATCCTCTCGGCAAAACTCGGGATCGCCACCGGCAAGAAC
CTGGCGGAGCAAATTCGCGACCATTATCCGCGTCCGGTAGTCTGGTTTTACTGGGTACAGGCGGAAATCATCGCGATGGC
CACCGATTTAGCTGAATTTATCGGCGCGGCAATAGGTTTTAAGCTGATCCTGGGCGTCTCTTTATTACAGGGCGCGGTAT
TGACCGGTATCGCGACGTTTCTGATTTTAATGTTACAGCGCCGCGGTCAAAAACCGCTTGAAAAAGTCATCGGCGGTTTA
CTGCTTTTTGTCGCCGCCGCTTACATTGTGGAGCTGTTTTTCTCTCAGCCTGATATGGCGCAGCTCGGCAAAGGAATGGT
TATCCCGGCGCTACCGAACCCGGAAGCCGTATTCTTAGCCGCCGGCGTGCTTGGCGCGACGATTATGCCGCACGTGATTT
ATCTGCACTCGTCATTAACGCAGCATCTGCACGGCGGAACACGGCAACAACGGTACTCAGCAACGAAATGGGATGTCGCT
ATTGCTATGACGATTGCCGGTTTTGTCAATCTGGCAATGATGGCGACCGCCGCGGCGGCGTTTCATTTTAGCGGCCACAC
CGGCATCGCCGACCTCGATCAGGCATACCTGACGCTGGAACCGTTACTAAGCCATGCGGCGGCAACGGTGTTTGGTCTTA
GTCTGGTAGCTGCAGGGCTTTCCTCCACTGTGGTAGGGACTCTGGCGGGGCAGGTGGTGATGCAAGGGTTTGTCCGTTTT
CACATTCCGCTGTGGGTACGGCGCACCATTACCATGCTGCCCTCATTTATTGTGATTTTGATGGGGCTGGACCCTACCCG
AATTCTGGTGATGAGCCAGGTGCTGCTGAGTTTTGGTATTGCGCTGGCGCTGGTGCCGCTCCTGATTTTCACCAGTAACG
CTACGCTAATGGGCGAGCTGGTGAACACGCGGCGGGTAAAACAGGTTGGCTGGATAATTGTCGTGCTGGTCGTCGCCCTG
AATATCTGGTTGCTGGTTGGAACGGTGATGGGGTTGTCATAA

Upstream 100 bases:

>100_bases
CTATCAAAGTAATCACCCGTACCCATTGAAATGCACTTGATAATCATTATCAATAAACATAGCATGAAACATAGCAAAGG
CTATGTTTTTGAGGCAAAAG

Downstream 100 bases:

>100_bases
AGACAGAAAGATAGCAGGCCCGATGCGTGGGCGTCATCGGGCTGTTATTCAGCAGGAGGCTTAGTGATGATGTTTGTGAC
CCCGGCCTCGCCCGCGATGA

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTDNRVENSSGRAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKN
LAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGL
LLFVAAAYIVELFFSQPDMAQLGKGMVIPALPNPEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGTRQQRYSATKWDVA
IAMTIAGFVNLAMMATAAAAFHFSGHTGIADLDQAYLTLEPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFVRF
HIPLWVRRTITMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSNATLMGELVNTRRVKQVGWIIVVLVVAL
NIWLLVGTVMGLS

Sequences:

>Translated_413_residues
MTDNRVENSSGRAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKN
LAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGL
LLFVAAAYIVELFFSQPDMAQLGKGMVIPALPNPEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGTRQQRYSATKWDVA
IAMTIAGFVNLAMMATAAAAFHFSGHTGIADLDQAYLTLEPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFVRF
HIPLWVRRTITMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSNATLMGELVNTRRVKQVGWIIVVLVVAL
NIWLLVGTVMGLS
>Mature_412_residues
TDNRVENSSGRAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNL
AEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLL
LFVAAAYIVELFFSQPDMAQLGKGMVIPALPNPEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGTRQQRYSATKWDVAI
AMTIAGFVNLAMMATAAAAFHFSGHTGIADLDQAYLTLEPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFVRFH
IPLWVRRTITMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSNATLMGELVNTRRVKQVGWIIVVLVVALN
IWLLVGTVMGLS

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=432, Percent_Identity=33.5648148148148, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI295293175, Length=445, Percent_Identity=31.2359550561798, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI295293173, Length=445, Percent_Identity=31.2359550561798, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI10835169, Length=445, Percent_Identity=31.2359550561798, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI295293167, Length=445, Percent_Identity=31.2359550561798, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI295293178, Length=445, Percent_Identity=31.2359550561798, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI295293171, Length=445, Percent_Identity=31.2359550561798, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI295293169, Length=445, Percent_Identity=31.2359550561798, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1788736, Length=412, Percent_Identity=93.6893203883495, Blast_Score=760, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193210616, Length=449, Percent_Identity=29.3986636971047, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17569473, Length=393, Percent_Identity=29.2620865139949, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71999499, Length=446, Percent_Identity=28.9237668161435, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71993856, Length=238, Percent_Identity=34.8739495798319, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323062, Length=390, Percent_Identity=33.8461538461538, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6324450, Length=425, Percent_Identity=28.7058823529412, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321841, Length=420, Percent_Identity=30.952380952381, Blast_Score=156, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24648607, Length=446, Percent_Identity=31.1659192825112, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI281362176, Length=446, Percent_Identity=31.1659192825112, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24648609, Length=446, Percent_Identity=31.1659192825112, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI45553443, Length=415, Percent_Identity=32.0481927710843, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_SALCH (Q57LU5)

Other databases:

- EMBL:   AE017220
- RefSeq:   YP_217398.1
- GeneID:   3334903
- GenomeReviews:   AE017220_GR
- KEGG:   sec:SC2411
- HOGENOM:   HBG312498
- OMA:   AYIVELV
- ProtClustDB:   PRK00701
- BioCyc:   SENT321314:SCH_2411-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 44401; Mature: 44269

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb3ccdf8)-; HASH(0xff045fc)-; HASH(0xfee10c0)-; HASH(0xfc5a718)-; HASH(0x101669e0)-; HASH(0xd5b581c)-; HASH(0x10670c8c)-; HASH(0x1066e72c)-; HASH(0xdfa1304)-; HASH(0x1015f84c)-; HASH(0xfc8be68)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
TDNRVENSSGRAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWAN
CCCCCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
KLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELFFSQPDMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
QLGKGMVIPALPNPEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGTRQQRYSATKWDVA
HHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHH
IAMTIAGFVNLAMMATAAAAFHFSGHTGIADLDQAYLTLEPLLSHAAATVFGLSLVAAGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSTVVGTLAGQVVMQGFVRFHIPLWVRRTITMLPSFIVILMGLDPTRILVMSQVLLSFGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ALALVPLLIFTSNATLMGELVNTRRVKQVGWIIVVLVVALNIWLLVGTVMGLS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA