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The map label for this gene is pgtP

Identifier: 16765725

GI number: 16765725

Start: 2512130

End: 2513521

Strand: Direct

Name: pgtP

Synonym: STM2399

Alternate gene names: 16765725

Gene position: 2512130-2513521 (Clockwise)

Preceding gene: 16765720

Following gene: 16765727

Centisome position: 51.72

GC content: 49.78

Gene sequence:

>1392_bases
ATGTTAACAATATTAAAAACAGGGCAATCGGCGCATAAAGTCCCACCGGAAAAAGTCCAGGCCACATATGGTCGATATCG
TATACAGGCATTGTTAAGTGTATTTCTGGGATATCTCGCTTACTATATAGTCAGAAACAACTTCACATTATCGACGCCTT
ATTTAAAAGAGCAATTGGATCTCAGCGCTACGCAAATCGGCCTGCTGAGTAGCTGTATGCTTATTGCTTACGGAATCAGT
AAAGGCGTAATGAGCAGTCTGGCGGATAAAGCCAGCCCAAAAGTCTTCATGGCGTGCGGTCTGGTACTCTGCGCGATTGT
TAACGTTGGGCTGGGATTCAGTAGCGCATTCTGGATATTTGCCGCTCTGGTGGTCTTCAATGGCCTTTTTCAGGGCATGG
GCGTCGGCCCCTCGTTTATTACTATTGCAAACTGGTTCCCTCGTCGGGAGCGCGGACGCGTAGGCGCCTTCTGGAATATC
TCGCATAACGTTGGCGGCGGGATCGTCGCGCCTATCGTCGGTGCGGCTTTTGCGATATTGGGCAGCGAACACTGGCAAAG
CGCCAGTTATATCGTTCCGGCCTGCGTCGCCGTCATTTTTGCCTTAATTGTTCTGGTCTTGGGAAAAGGTTCGCCGCGCA
AAGAAGGTCTTCCCTCCCTGGAACAGATGATGCCGGAAGAAAAAGTCGTACTGAAAACGAAGAATACGGCAAAAGCGCCG
GAAAATATGAGCGCATGGCAAATCTTCTGTACTTATGTGCTGCGCAATAAAAATGCCTGGTATATTTCGCTGGTGGATGT
CTTCGTCTATATGGTGCGGTTTGGCATGATTAGCTGGTTGCCTATCTATCTGTTGACAGTAAAACACTTTTCAAAAGAAC
AGATGAGCGTCGCGTTTCTCTTTTTCGAGTGGGCGGCGATTCCCTCCACGCTACTGGCAGGCTGGCTGTCAGATAAACTG
TTTAAGGGCCGCAGAATGCCGTTAGCCATGATTTGCATGGCGCTGATTTTTGTCTGTCTGATCGGATACTGGAAAAGTGA
ATCTTTGCTGATGGTAACGATTTTCGCCGCCATTGTAGGTTGTCTGATTTACGTCCCGCAGTTCCTCGCGTCCGTACAGA
CAATGGAAATAGTCCCCAGCTTTGCCGTAGGTTCCGCCGTCGGTTTACGTGGGTTCATGAGCTATATTTTCGGCGCCTCG
TTGGGCACCAGCCTGTTTGGTGTAATGGTGGATAAACTTGGCTGGTACGGCGGATTTTATCTTCTGATGGGCGGCATCGT
GTGCTGCATTCTATTCTGTTACCTCTCCCATCGCGGCGCGCTGGAACTGGAACGCCAGCGCCAGAATGCGTTACATAATC
AGGACTCACTGCAGCTTGCGGACGCGCAATAA

Upstream 100 bases:

>100_bases
ATTTTGACACATTTCTTCGACTTGAATTTTATTGTCACTCCTTTCACTCTACCGACAAAACCTCCTGATGTTCATCTCAC
TATAAAATACAGGTGACTCC

Downstream 100 bases:

>100_bases
ACGATTAGCCTTCCTGGGGAACAGAAGCGCCGACATTGTCGGCGCTATCTATTCACTGGCATCGTATATACCCAAAATAA
TTCGAGTTGCTTAAAGGCGG

Product: transporter

Products: Proton [Cytoplasm]; glycerol-3-phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLTILKTGQSAHKVPPEKVQATYGRYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGIS
KGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNI
SHNVGGGIVAPIVGAAFAILGSEHWQSASYIVPACVAVIFALIVLVLGKGSPRKEGLPSLEQMMPEEKVVLKTKNTAKAP
ENMSAWQIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKL
FKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGAS
LGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFCYLSHRGALELERQRQNALHNQDSLQLADAQ

Sequences:

>Translated_463_residues
MLTILKTGQSAHKVPPEKVQATYGRYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGIS
KGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNI
SHNVGGGIVAPIVGAAFAILGSEHWQSASYIVPACVAVIFALIVLVLGKGSPRKEGLPSLEQMMPEEKVVLKTKNTAKAP
ENMSAWQIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKL
FKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGAS
LGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFCYLSHRGALELERQRQNALHNQDSLQLADAQ
>Mature_463_residues
MLTILKTGQSAHKVPPEKVQATYGRYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGIS
KGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNI
SHNVGGGIVAPIVGAAFAILGSEHWQSASYIVPACVAVIFALIVLVLGKGSPRKEGLPSLEQMMPEEKVVLKTKNTAKAP
ENMSAWQIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKL
FKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGAS
LGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFCYLSHRGALELERQRQNALHNQDSLQLADAQ

Specific function: The phosphoglycerate transporter protein is a part of the PGT transport system. It is the membrane bound transporter for phosphoglycerate into salmonella

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family

Homologues:

Organism=Homo sapiens, GI256219598, Length=412, Percent_Identity=26.4563106796117, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4503847, Length=412, Percent_Identity=26.4563106796117, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI256219483, Length=412, Percent_Identity=26.4563106796117, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI256219543, Length=434, Percent_Identity=25.5760368663594, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI38093649, Length=406, Percent_Identity=24.384236453202, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI223717983, Length=409, Percent_Identity=23.960880195599, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1788573, Length=462, Percent_Identity=36.3636363636364, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI2367259, Length=457, Percent_Identity=32.8227571115974, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87082310, Length=448, Percent_Identity=30.3571428571429, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI2367379, Length=328, Percent_Identity=25.609756097561, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI2367193, Length=448, Percent_Identity=22.3214285714286, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082320, Length=398, Percent_Identity=22.3618090452261, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17564202, Length=403, Percent_Identity=22.0843672456576, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17564204, Length=403, Percent_Identity=22.0843672456576, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17542316, Length=445, Percent_Identity=20.6741573033708, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133901856, Length=443, Percent_Identity=22.3476297968397, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI133901854, Length=443, Percent_Identity=22.3476297968397, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24656866, Length=486, Percent_Identity=21.6049382716049, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45550478, Length=486, Percent_Identity=21.6049382716049, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24656861, Length=486, Percent_Identity=21.6049382716049, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGTP_SALTY (P12681)

Other databases:

- EMBL:   AE006468
- EMBL:   M21278
- PIR:   A31089
- RefSeq:   NP_461340.1
- ProteinModelPortal:   P12681
- SMR:   P12681
- GeneID:   1253921
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2399
- NMPDR:   fig|99287.1.peg.2321
- HOGENOM:   HBG559184
- OMA:   RIQIFAI
- ProtClustDB:   CLSK894310
- BioCyc:   STYP99287:STM2399-MONOMER
- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159
- TIGRFAMs:   TIGR00881

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 50999; Mature: 50999

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00942 GLPT; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf07cb7c)-; HASH(0x10368698)-; HASH(0xf8b18d8)-; HASH(0x102d1918)-; HASH(0x1013dd4c)-; HASH(0xfffe484)-; HASH(0x1052e5a0)-; HASH(0x102a8230)-; HASH(0xf963c54)-; HASH(0x1011fb70)-; HASH(0x100d5400)-; HASH(0xfd5bef0)-;

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTILKTGQSAHKVPPEKVQATYGRYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLD
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHC
LSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
AALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAIL
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
GSEHWQSASYIVPACVAVIFALIVLVLGKGSPRKEGLPSLEQMMPEEKVVLKTKNTAKAP
CCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCC
ENMSAWQIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFL
CCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
FFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
CLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGGFY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMGGIVCCILFCYLSHRGALELERQRQNALHNQDSLQLADAQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEECCCH
>Mature Secondary Structure
MLTILKTGQSAHKVPPEKVQATYGRYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLD
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHC
LSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
AALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAIL
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
GSEHWQSASYIVPACVAVIFALIVLVLGKGSPRKEGLPSLEQMMPEEKVVLKTKNTAKAP
CCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCC
ENMSAWQIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFL
CCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
FFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
CLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGGFY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMGGIVCCILFCYLSHRGALELERQRQNALHNQDSLQLADAQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEECCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glycerol-3-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glycerol-3-phosphate [Periplasm] = Proton [Cytoplasm] + glycerol-3-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 3042749