| Definition | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome. |
|---|---|
| Accession | NC_003197 |
| Length | 4,857,432 |
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The map label for this gene is menD [H]
Identifier: 16765636
GI number: 16765636
Start: 2415626
End: 2417296
Strand: Reverse
Name: menD [H]
Synonym: STM2309
Alternate gene names: 16765636
Gene position: 2417296-2415626 (Counterclockwise)
Preceding gene: 16765637
Following gene: 16765635
Centisome position: 49.76
GC content: 59.49
Gene sequence:
>1671_bases ATGTCAGTAAGTGCATTTAACCGGCGCTGGGCGGCGGTCATCCTGGAAGCCTTAACCCGTCATGGCGTCAGGCATGTTTG TATCGCCCCTGGTTCCCGTTCCACGCCGCTCACGTTGGCGGCGGCAGAGAATCCTGCTTTTATTCACCATACGCACTTTG ATGAGCGTGGGCTTGGTCATCTGGCGTTAGGGCTGGCGAAAGTCAGCCAACAGCCGGTTGCCGTTATTGTCACTTCAGGT ACCGCCGTGGCGAACCTCTATCCGGCGTTGATTGAGGCGGGGCTGACGGGCGAGAAGCTCATTTTACTTACCGCCGATCG CCCGCCAGAGCTGATTGACTGCGGCGCCAACCAGGCGATCCGTCAGGCGGGGATGTTTGCCTCGCACCCCTCCCAAACTT TGTCGTTGCCGCGTCCCACGCAGGATATTCCGGCGCGCTGGCTGGTGTCGACCATCGACAATGCGCTCGCCATGCTTCAT GCGGGCGCGCTGCACATTAACTGTCCTTTTGCCGAACCGCTGTATGGCGATATGAATGATACCGGTCTGGTCTGGCAGCA GCGTCTCGGCGACTGGTGGCAGGATGAAAAACCCTGGCTGCGCGAAGCGCGTCGACTGGAAAGCGACAAACAGCGCGACT GGTTCTTCTGGCGACAAAAACGCGGCGTTGTCGTCGCCGGGCGTATGAGCGCGGAAGAAGGCAAAAAAGTGGCGCAGTGG GCGCAAACTCTGGGATGGCCATTAATTGGCGACGTATTGTCGCAAACCGGGCAGCCGCTGCCGTGCGCCGACCTGTGGCT CGGCAACGCCAAAGCGGTGACCGAACTGCAGCAGGCGCAGATTGTCGTCCAGCTTGGCAGTAGCCTTACCGGAAAACGCT TACTGCAATGGCAGGCAACCTGCGAGCCGGAAGAGTACTGGGTAATCGACAATATTGAAGGTCGTCTGGACCCGGCGCAC CATCGTGGACGCAGACTGGTAGCGAAAATCGCCGATTGGCTGGAACTGCATCCGGCGGAAAAACGTAAACCGTGGTGTGT AGAGATCCCGCGTCTGGCGGAACTGGCGTGGCAACGGGTGGTCGCGCAGCGAGACACCTTTGGCGAAGCGCAGCTGGCGC ACCGTATCCGCGACTATCTGCCGGAGCAGGGGCAATTGTTCGTGGGCAATAGTCTGGTGGTGCGTCTGATCGACGCGCTG TCACAGTTGCCGGCTGGCTATCCGGTATACAGCAATCGCGGGGCGAGCGGCATTGACGGCCTGCTTTCCACGGCGGCGGG CGTGCAGCGCGCCAGCGCTAAATCGACGCTGGCTATCGTCGGCGATTTATCCGCGCTGTACGATCTTAACGCGCTGGCGT TACTACGTCAGGTATCCGCGCCGTTTGTGTTGATTGTGGTCAACAATAACGGCGGGCAAATCTTCTCCCTGCTGCCGACG CCGCAAAGCAAACGTGAGCGCTTTTATTTGATGCCGCAAAACGTCCATTTTGACCATGCGGCCGCCATGTTTAACCTGCG CTATCATCGCCCGGAAAACTGGGAAGAACTGGAGTCTGCGCTGGCTGGCGCGTGGCGAACCCCGGCGACAACGGTGATTG AGCTGGTGGTAAACGATACGGACGGCGCGCAGACGTTGCAGCAACTTTTGGCTCAGGTAAGCCATCTATGA
Upstream 100 bases:
>100_bases CAGATGGATGCGTAATGAGTCACATATTCCCGACCCATATCAATAATCCATTTTTGCAGCTCTTTATACTTAGTCCCAAT GATTGATACCGGACAAACTC
Downstream 100 bases:
>100_bases TGTTGCACGCGCAGCACATGCCCGGACAGCCTGGGACGCCCTCGCTGGTTTTCCTGCACGGTTTTTCTGGCGATTGCCAC GAATGGCAGCCGGTTGGCGA
Product: 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase
Products: NA
Alternate protein names: SEPHCHC synthase; Menaquinone biosynthesis protein menD [H]
Number of amino acids: Translated: 556; Mature: 555
Protein sequence:
>556_residues MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSG TAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLH AGALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLESDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQW AQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAH HRGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDAL SQLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPT PQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDTDGAQTLQQLLAQVSHL
Sequences:
>Translated_556_residues MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSG TAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLH AGALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLESDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQW AQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAH HRGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDAL SQLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPT PQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDTDGAQTLQQLLAQVSHL >Mature_555_residues SVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSGT AVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHA GALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLESDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQWA QTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAHH RGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALS QLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPTP QSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDTDGAQTLQQLLAQVSHL
Specific function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-ca
COG id: COG1165
COG function: function code H; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family. MenD subfamily [H]
Homologues:
Organism=Escherichia coli, GI1788599, Length=556, Percent_Identity=91.0071942446043, Blast_Score=1047, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004433 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.9 [H]
Molecular weight: Translated: 61524; Mature: 61393
Theoretical pI: Translated: 7.29; Mature: 7.29
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGH CCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCHH LALGLAKVSQQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAI HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCHHH RQAGMFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHAGALHINCPFAEPLYGDMND HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC TGLVWQQRLGDWWQDEKPWLREARRLESDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQW CHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHEECCCCEEEEECCCHHHHHHHHHH AQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQAT HHHHCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC CEPEEYWVIDNIEGRLDPAHHRGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRV CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHH VAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDG HHHCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH LLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPT HHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCC PQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDT CCCCCCEEEECCCCCCCHHHHHEEEEEECCCCCHHHHHHHHHCCCCCCHHEEEEEEEECC DGAQTLQQLLAQVSHL CHHHHHHHHHHHHHCC >Mature Secondary Structure SVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGH CCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCCHH LALGLAKVSQQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAI HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCHHH RQAGMFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHAGALHINCPFAEPLYGDMND HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC TGLVWQQRLGDWWQDEKPWLREARRLESDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQW CHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHEECCCCEEEEECCCHHHHHHHHHH AQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQAT HHHHCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC CEPEEYWVIDNIEGRLDPAHHRGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRV CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHH VAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDG HHHCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH LLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPT HHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCC PQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDT CCCCCCEEEECCCCCCCHHHHHEEEEEECCCCCHHHHHHHHHCCCCCCHHEEEEEEEECC DGAQTLQQLLAQVSHL CHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA