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The map label for this gene is yegH [H]

Identifier: 16765449

GI number: 16765449

Start: 2203325

End: 2204905

Strand: Direct

Name: yegH [H]

Synonym: STM2119

Alternate gene names: 16765449

Gene position: 2203325-2204905 (Clockwise)

Preceding gene: 16765408

Following gene: 16765453

Centisome position: 45.36

GC content: 54.14

Gene sequence:

>1581_bases
ATGGAATGGATTGCCGATCCGTCAATCTGGGCCGGACTGGTAACGTTAATCGTTATCGAACTTGTTCTCGGCATTGATAA
CCTGGTCTTTATTGCCATCCTCGCTGAAAAACTACCGCCGGGGCAGCGCGACCGCGCGCGCATTACCGGCCTGATACTGG
CGATGATCATGCGCCTGCTGCTGCTGGCGTCAATCTCGTGGCTGGTCACCTTGACTAAGCCGCTTTTTAGCGTACAGGCG
TTAAGCTTTAGCGCCCGCGATCTGATTATGCTGTTCGGCGGCTTCTTCCTGCTCTTTAAAGCCACCATGGAGCTCAACGA
ACGGCTGGAAGGGAAAGATAGCGCCAACCCTACCCAGCGTAAGGGGGCGAAATTCTGGGCGGTGGTCGCGCAAATCGTGG
TGCTGGACGCTATCTTTTCTCTCGACTCCGTGATTACCGCCGTGGGGATGGTCGATCACCTGGCGGTCATGATGGCGGCC
GTGATAATCGCCATTAGCCTGATGCTGCTCGCCAGCAAGTCACTGACCCGATTTGTGAACAACCATCCCACCATTGTCAT
TTTGTGTCTTAGCTTCCTGCTAATGATCGGCTTTAGCCTGGTGGCGGAAGGGTTTGGTTTCCACATTCCGAAAGGGTATC
TGTACGCGGCTATCGGCTTCTCGGTGATGATCGAGGCGCTCAACCAACTGGCTATTTTTAACCGCCGCCGTTTTCTTTCC
GCTAACCATACGCTGCGCCAGCGCACAACGGAGGCCGTGATGCGGCTGATTAGCGGTAAAAAAGAGGATGCCGAACTGGA
TGCGGAAACCGCCGCGATGCTGGCAGACCATGACGACAGCCAGATTTTTAATCCGCAGGAGCGCAGGATGATTGAGCGGG
TGCTGAATCTCAACCAGCGCACCGTAAGTAGCATCATGACGTCGCGTCACGATATCGAGCATATCGATCTCAACGCGCCG
GAAGCGGAAATCCGCGCTCTGCTGGAAAAGAACCAGCATACGCGTCTGGTCGTGACGGGTGAAAATGAACAGGAAGATTT
ACTCGGCGTCGTCCACGTCATCGATCTGTTGCAACAATCGCTGCGCGGCGAACCGCTCAACCTGCGGGCGCTGATTCGCC
AACCGCTGGTTTTCCCGGAAACATTGCCGCTGCTGCCTGCGCTGGAGCAGTTCCGTAACGCCAGAACCCATTTTGCCTTT
GTCGTAGATGAGTTTGGCTCGGTTGAAGGCATTGTGACATTAAGCGATGTCATGGAGACTATTGCCGGTAATCTGCCGAA
TGAAGTCGAGGAAATTGACGCCCGCCACGATATTCAGAAGAACCCGGACGGTTCCTGGACAGCAAACGGCCATATGCCGC
TGGAGGATTTGGTGCAGTACGTGCCGCTACCGCTGGATGAAAAACGGGAATACCATACGATTGCCGGATTATTGATGGAA
TATTTGCAACGCATACCGCAAACCGGTGAAGAGGTTCAGGTGGGCGATTATTTGCTGAAAACATTGCAGGTAGAAAGCCA
TCGAGTGCAGAAAGTGCAGTTAATTCCGCTGCATAACGGCGAGCCAGACCAGGAGATGTAA

Upstream 100 bases:

>100_bases
GTAACAAAGATAAATTGCGCTGCGGCATTGCATTTTTCCGCCGTATTATCCATGATCGAATTGTGACAATTGTCATATTA
CAGAAGGTATTGCTCTTACT

Downstream 100 bases:

>100_bases
CGTCTGTTCGCCTGCCCCGGTCTGCTTACCAGGCAGGCCGGAGGCGCGTTAGCCTCGCCATCCGGCTCTGCCCTTTGGCC
AAAAACTACAGCTTATTCAG

Product: inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MEWIADPSIWAGLVTLIVIELVLGIDNLVFIAILAEKLPPGQRDRARITGLILAMIMRLLLLASISWLVTLTKPLFSVQA
LSFSARDLIMLFGGFFLLFKATMELNERLEGKDSANPTQRKGAKFWAVVAQIVVLDAIFSLDSVITAVGMVDHLAVMMAA
VIIAISLMLLASKSLTRFVNNHPTIVILCLSFLLMIGFSLVAEGFGFHIPKGYLYAAIGFSVMIEALNQLAIFNRRRFLS
ANHTLRQRTTEAVMRLISGKKEDAELDAETAAMLADHDDSQIFNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAP
EAEIRALLEKNQHTRLVVTGENEQEDLLGVVHVIDLLQQSLRGEPLNLRALIRQPLVFPETLPLLPALEQFRNARTHFAF
VVDEFGSVEGIVTLSDVMETIAGNLPNEVEEIDARHDIQKNPDGSWTANGHMPLEDLVQYVPLPLDEKREYHTIAGLLME
YLQRIPQTGEEVQVGDYLLKTLQVESHRVQKVQLIPLHNGEPDQEM

Sequences:

>Translated_526_residues
MEWIADPSIWAGLVTLIVIELVLGIDNLVFIAILAEKLPPGQRDRARITGLILAMIMRLLLLASISWLVTLTKPLFSVQA
LSFSARDLIMLFGGFFLLFKATMELNERLEGKDSANPTQRKGAKFWAVVAQIVVLDAIFSLDSVITAVGMVDHLAVMMAA
VIIAISLMLLASKSLTRFVNNHPTIVILCLSFLLMIGFSLVAEGFGFHIPKGYLYAAIGFSVMIEALNQLAIFNRRRFLS
ANHTLRQRTTEAVMRLISGKKEDAELDAETAAMLADHDDSQIFNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAP
EAEIRALLEKNQHTRLVVTGENEQEDLLGVVHVIDLLQQSLRGEPLNLRALIRQPLVFPETLPLLPALEQFRNARTHFAF
VVDEFGSVEGIVTLSDVMETIAGNLPNEVEEIDARHDIQKNPDGSWTANGHMPLEDLVQYVPLPLDEKREYHTIAGLLME
YLQRIPQTGEEVQVGDYLLKTLQVESHRVQKVQLIPLHNGEPDQEM
>Mature_526_residues
MEWIADPSIWAGLVTLIVIELVLGIDNLVFIAILAEKLPPGQRDRARITGLILAMIMRLLLLASISWLVTLTKPLFSVQA
LSFSARDLIMLFGGFFLLFKATMELNERLEGKDSANPTQRKGAKFWAVVAQIVVLDAIFSLDSVITAVGMVDHLAVMMAA
VIIAISLMLLASKSLTRFVNNHPTIVILCLSFLLMIGFSLVAEGFGFHIPKGYLYAAIGFSVMIEALNQLAIFNRRRFLS
ANHTLRQRTTEAVMRLISGKKEDAELDAETAAMLADHDDSQIFNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAP
EAEIRALLEKNQHTRLVVTGENEQEDLLGVVHVIDLLQQSLRGEPLNLRALIRQPLVFPETLPLLPALEQFRNARTHFAF
VVDEFGSVEGIVTLSDVMETIAGNLPNEVEEIDARHDIQKNPDGSWTANGHMPLEDLVQYVPLPLDEKREYHTIAGLLME
YLQRIPQTGEEVQVGDYLLKTLQVESHRVQKVQLIPLHNGEPDQEM

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=340, Percent_Identity=22.3529411764706, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87082033, Length=527, Percent_Identity=90.5123339658444, Blast_Score=942, Evalue=0.0,
Organism=Escherichia coli, GI1788119, Length=526, Percent_Identity=50.1901140684411, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789197, Length=226, Percent_Identity=50.8849557522124, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI1790664, Length=238, Percent_Identity=31.9327731092437, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786879, Length=263, Percent_Identity=27.3764258555133, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI145693175, Length=277, Percent_Identity=25.6317689530686, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005496
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF03741 TerC [H]

EC number: NA

Molecular weight: Translated: 58975; Mature: 58975

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCC
>Mature Secondary Structure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HHHHCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]