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The map label for this gene is cbiC

Identifier: 16765363

GI number: 16765363

Start: 2110823

End: 2111455

Strand: Reverse

Name: cbiC

Synonym: STM2033

Alternate gene names: 16765363

Gene position: 2111455-2110823 (Counterclockwise)

Preceding gene: 16765364

Following gene: 16765362

Centisome position: 43.47

GC content: 55.45

Gene sequence:

>633_bases
ATGCATTATATCCAGCAGCCCCAAACCATTGAGGCCAACAGTTTCACCATTATTAGCGACATTATTCGCGAAACGCGTCC
TGATTACCGTTTCGCCAGTCCGCTCCATGAGGCCATTATCAAGCGGGTTATTCATACCACCGCCGATTTCGACTGGCTGG
ACATTTTGTGGTTCTCTGCCGATGCGCTGGAGCAGCTTTGTGATGCGTTACGCCATCCGTGCATTATTTATACCGATACC
ACGATGGCGCTGTCCGGCATTAATAAAAGATTACTGGCGACGTTTGGCGGCGAGTGTCGCTGTTATATCAGCGATCCGCG
CGTGGTGCGCGCCGCACAAACGCAGGGGATTACCCGTTCAATGGCCGCCGTCGATATCGCTATCGCCGAGGAGGAGAAAA
ACAAGCTCTTTGTTTTCGGTAATGCGCCGACGGCCCTGTTCCGTTTGCTTGAACATAACGTGACGGTGAGCGGCGTGGTG
GGCGTACCGGTAGGCTTTGTCGGCGCGGCGGAGTCCAAAGAGGCACTCACCCATAGCCATTTCCCCGCGGTTGCCGCGTT
AGGGCGTAAAGGCGGCAGTAACGTGGCTGCCGCTATCGTCAATGCGTTGCTCTATCACCTCCGGGAGGCCTGA

Upstream 100 bases:

>100_bases
TCCCGAACGATTCGATTGATGTGGGTCGCTTCAACCCTGGCGCTGGCGCTGTTAATTGCGGCGCGGTGCGGGTTATCTGG
CGTGGCCTGAGGACGACAGT

Downstream 100 bases:

>100_bases
TGAGCGAGCTTTCTTTTGACGCGCCGGTCTGGCACCACGGTAAAGCGTTACGTAAAGGATATACCACCGGTTCCTGCGCG
ACGGCGGCGGCAAAAGTCGC

Product: cobalt-precorrin-8X methylmutase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MHYIQQPQTIEANSFTIISDIIRETRPDYRFASPLHEAIIKRVIHTTADFDWLDILWFSADALEQLCDALRHPCIIYTDT
TMALSGINKRLLATFGGECRCYISDPRVVRAAQTQGITRSMAAVDIAIAEEEKNKLFVFGNAPTALFRLLEHNVTVSGVV
GVPVGFVGAAESKEALTHSHFPAVAALGRKGGSNVAAAIVNALLYHLREA

Sequences:

>Translated_210_residues
MHYIQQPQTIEANSFTIISDIIRETRPDYRFASPLHEAIIKRVIHTTADFDWLDILWFSADALEQLCDALRHPCIIYTDT
TMALSGINKRLLATFGGECRCYISDPRVVRAAQTQGITRSMAAVDIAIAEEEKNKLFVFGNAPTALFRLLEHNVTVSGVV
GVPVGFVGAAESKEALTHSHFPAVAALGRKGGSNVAAAIVNALLYHLREA
>Mature_210_residues
MHYIQQPQTIEANSFTIISDIIRETRPDYRFASPLHEAIIKRVIHTTADFDWLDILWFSADALEQLCDALRHPCIIYTDT
TMALSGINKRLLATFGGECRCYISDPRVVRAAQTQGITRSMAAVDIAIAEEEKNKLFVFGNAPTALFRLLEHNVTVSGVV
GVPVGFVGAAESKEALTHSHFPAVAALGRKGGSNVAAAIVNALLYHLREA

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CBIC_SALTY (Q05601)

Other databases:

- EMBL:   L12006
- EMBL:   AE006468
- PIR:   S21127
- RefSeq:   NP_460978.1
- ProteinModelPortal:   Q05601
- SMR:   Q05601
- PRIDE:   Q05601
- GeneID:   1253554
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2033
- NMPDR:   fig|99287.1.peg.1958
- HOGENOM:   HBG553498
- OMA:   KAGIRYN
- ProtClustDB:   PRK08286
- BioCyc:   MetaCyc:MONOMER-13227
- BioCyc:   STYP99287:STM2033-MONOMER
- InterPro:   IPR003722
- Gene3D:   G3DSA:3.40.50.10230

Pfam domain/function: PF02570 CbiC; SSF63965 CbiC

EC number: 5.4.1.2

Molecular weight: Translated: 23035; Mature: 23035

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: ACT_SITE 45-45

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYIQQPQTIEANSFTIISDIIRETRPDYRFASPLHEAIIKRVIHTTADFDWLDILWFSA
CCCCCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCH
DALEQLCDALRHPCIIYTDTTMALSGINKRLLATFGGECRCYISDPRVVRAAQTQGITRS
HHHHHHHHHHHCCEEEEECCHHHHHHCCHHHHHHCCCCEEEEECCCCEEHHHHHCCHHHH
MAAVDIAIAEEEKNKLFVFGNAPTALFRLLEHNVTVSGVVGVPVGFVGAAESKEALTHSH
HHHHEEEEEECCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHCC
FPAVAALGRKGGSNVAAAIVNALLYHLREA
CHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHYIQQPQTIEANSFTIISDIIRETRPDYRFASPLHEAIIKRVIHTTADFDWLDILWFSA
CCCCCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCH
DALEQLCDALRHPCIIYTDTTMALSGINKRLLATFGGECRCYISDPRVVRAAQTQGITRS
HHHHHHHHHHHCCEEEEECCHHHHHHCCHHHHHHCCCCEEEEECCCCEEHHHHHCCHHHH
MAAVDIAIAEEEKNKLFVFGNAPTALFRLLEHNVTVSGVVGVPVGFVGAAESKEALTHSH
HHHHEEEEEECCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHCC
FPAVAALGRKGGSNVAAAIVNALLYHLREA
CHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8501034; 11677609; 1451790