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The map label for this gene is cheA

Identifier: 16765263

GI number: 16765263

Start: 2017178

End: 2019193

Strand: Reverse

Name: cheA

Synonym: STM1921

Alternate gene names: 16765263

Gene position: 2019193-2017178 (Counterclockwise)

Preceding gene: 16765264

Following gene: 16765262

Centisome position: 41.57

GC content: 55.31

Gene sequence:

>2016_bases
GTGAGCATGGATATTAGCGATTTTTATCAGACATTTTTTGATGAAGCTGACGAGCTGTTGGCTGATATGGAGCAGCATCT
GCTGGATTTGGTGCCGGAGTCCCCGGACGCTGAACAACTGAACGCCATTTTTCGCGCGGCGCACTCCATTAAAGGCGGCG
CGGGCACATTCGGCTTCACTATTCTGCAGGAAACCACGCATTTAATGGAAAACCTGCTGGATGAAGCCCGACGCGGTGAA
ATGCAGCTCAATACCGACATTATCAACCTGTTTTTGGAAACGAAAGATATTATGCAGGAACAGCTCGACGCCTATAAAAA
CTCCGAAGAGCCGGATGCCGCAAGCTTCGAATATATCTGCAATGCGCTACGCCAGTTGGCGCTGGAGGCGAAAGGCGAAA
CCACGCCGGCGGTCGTAGAAACCGCGGCACTAAGCGCGGCGATCCAGGAAGAGAGCGTAGCCGAAACCGAATCGCCTCGT
GACGAGAGTAAACTGCGCATTGTACTTTCACGGTTGAAAGCCAATGAGGTCGATCTGCTTGAAGAAGAGTTGGGCAATCT
GGCTACTCTGACGGATGTCGTTAAGGGGGCGGATTCACTGTCGGCAACTCTGGATGGCAGCGTCGCGGAAGATGACATTG
TCGCGGTGCTCTGTTTTGTCATCGAGGCCGATCAGATCGCTTTTGAAAAAGTGGTCGCCGCGCCGGTTGAAAAAGCGCAA
GAGAAAACCGAGGTAGCGCCGGTAGCGCCTCCGGCAGTCGTTGCGCCAGCCGCCAAAAGCGCGGCCCATGAACATCATGC
GGGGCGTGAAAAACCTGCGCGTGAACGCGAGTCCACCAGCATTCGCGTGGCGGTAGAGAAAGTGGATCAGCTCATAAACC
TGGTCGGCGAGTTAGTGATTACCCAGTCAATGTTGGCCCAGCGTTCTAACGAGCTGGACCCGGTAAACCACGGCGATCTC
ATTACCAGTATGGGTCAGTTACAACGTAACGCCCGCGACTTACAAGAGTCGGTGATGTCGATTCGTATGATGCCTATGGA
GTACGTCTTCAGCCGTTTCCCGCGTCTGGTACGCGATTTAGCGGGCAAACTGGGCAAGCAGGTAGAGCTGACGCTGGTGG
GGAGCTCCACTGAACTTGATAAAAGCCTGATCGAACGCATTATCGACCCGCTGACGCACCTGGTGCGCAACAGTCTCGAC
CACGGGATTGAAATGCCGGAAAAACGCCTTGAGGCGGGGAAAAATGTTGTCGGCAATCTGATTCTTTCCGCAGAACATCA
GGGCGGGAATATTTGTATTGAAGTGACCGATGACGGCGCGGGGCTTAACCGTGAGCGTATCCTGGCGAAGGCCATGTCGC
AGGGGATGGCGGTGAATGAAAACATGACCGACGATGAAGTAGGCATGTTGATCTTCGCGCCGGGATTCTCAACTGCGGAA
CAGGTCACGGATGTCTCCGGTCGCGGCGTTGGCATGGATGTGGTGAAACGTAACATTCAGGAGATGGGCGGTCACGTTGA
GATCCAGTCAAAACAAGGCTCCGGCACCACGATTCGTATTCTGCTGCCGCTGACGCTGGCCATCCTCGATGGGATGTCGG
TTCGCGTGGCGGGGGAAGTTTTTATCCTGCCGTTGAATGCGGTGATGGAGTCGCTGCAACCGCGTGAAGAGGATCTTCAT
CCGCTGGCGGGCGGCGAACGGGTTCTGGAAGTTCGCGGCGAGTATTTGCCGCTGGTCGAATTGTGGAAAGTGTTTGACGT
GGACGGGGCGAAAACCGAAGCCACGCAGGGCATTGTTGTGATCCTGCAAAGCGCGGGACGCCGTTACGCGCTGCTGGTCG
ATCAGCTCATCGGTCAGCACCAGGTGGTGGTCAAAAATCTGGAAAGCAATTATCGCAAGGTACCGGGGATTTCCGCCGCG
ACGATCCTGGGCGACGGCAGCGTCGCGCTGATTGTTGATGTTTCCGCATTGCAGGGTTTAAACCGCGAACAACGTATGGC
GATCACAGCCGCCTGA

Upstream 100 bases:

>100_bases
GCTGAAAGCCAGAATGAGCCGGTAAGTGTATTACAACAGCCTGCGGCAGCCCCGCCGGCAAGCGTACCCACATCGCCAAA
AGCGGAACCGAGGTGATAGC

Downstream 100 bases:

>100_bases
TTGAGTGAGAAGGGAATAATATGACCGGTATGAGTAATGTAAGCAAACTGGCCGGCGAGCCGTCAGGTCAGGAATTCCTG
GTGTTTACACTGGGAAATGA

Product: chemotaxis protein CheA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MSMDISDFYQTFFDEADELLADMEQHLLDLVPESPDAEQLNAIFRAAHSIKGGAGTFGFTILQETTHLMENLLDEARRGE
MQLNTDIINLFLETKDIMQEQLDAYKNSEEPDAASFEYICNALRQLALEAKGETTPAVVETAALSAAIQEESVAETESPR
DESKLRIVLSRLKANEVDLLEEELGNLATLTDVVKGADSLSATLDGSVAEDDIVAVLCFVIEADQIAFEKVVAAPVEKAQ
EKTEVAPVAPPAVVAPAAKSAAHEHHAGREKPARERESTSIRVAVEKVDQLINLVGELVITQSMLAQRSNELDPVNHGDL
ITSMGQLQRNARDLQESVMSIRMMPMEYVFSRFPRLVRDLAGKLGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLD
HGIEMPEKRLEAGKNVVGNLILSAEHQGGNICIEVTDDGAGLNRERILAKAMSQGMAVNENMTDDEVGMLIFAPGFSTAE
QVTDVSGRGVGMDVVKRNIQEMGGHVEIQSKQGSGTTIRILLPLTLAILDGMSVRVAGEVFILPLNAVMESLQPREEDLH
PLAGGERVLEVRGEYLPLVELWKVFDVDGAKTEATQGIVVILQSAGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAA
TILGDGSVALIVDVSALQGLNREQRMAITAA

Sequences:

>Translated_671_residues
MSMDISDFYQTFFDEADELLADMEQHLLDLVPESPDAEQLNAIFRAAHSIKGGAGTFGFTILQETTHLMENLLDEARRGE
MQLNTDIINLFLETKDIMQEQLDAYKNSEEPDAASFEYICNALRQLALEAKGETTPAVVETAALSAAIQEESVAETESPR
DESKLRIVLSRLKANEVDLLEEELGNLATLTDVVKGADSLSATLDGSVAEDDIVAVLCFVIEADQIAFEKVVAAPVEKAQ
EKTEVAPVAPPAVVAPAAKSAAHEHHAGREKPARERESTSIRVAVEKVDQLINLVGELVITQSMLAQRSNELDPVNHGDL
ITSMGQLQRNARDLQESVMSIRMMPMEYVFSRFPRLVRDLAGKLGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLD
HGIEMPEKRLEAGKNVVGNLILSAEHQGGNICIEVTDDGAGLNRERILAKAMSQGMAVNENMTDDEVGMLIFAPGFSTAE
QVTDVSGRGVGMDVVKRNIQEMGGHVEIQSKQGSGTTIRILLPLTLAILDGMSVRVAGEVFILPLNAVMESLQPREEDLH
PLAGGERVLEVRGEYLPLVELWKVFDVDGAKTEATQGIVVILQSAGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAA
TILGDGSVALIVDVSALQGLNREQRMAITAA
>Mature_670_residues
SMDISDFYQTFFDEADELLADMEQHLLDLVPESPDAEQLNAIFRAAHSIKGGAGTFGFTILQETTHLMENLLDEARRGEM
QLNTDIINLFLETKDIMQEQLDAYKNSEEPDAASFEYICNALRQLALEAKGETTPAVVETAALSAAIQEESVAETESPRD
ESKLRIVLSRLKANEVDLLEEELGNLATLTDVVKGADSLSATLDGSVAEDDIVAVLCFVIEADQIAFEKVVAAPVEKAQE
KTEVAPVAPPAVVAPAAKSAAHEHHAGREKPARERESTSIRVAVEKVDQLINLVGELVITQSMLAQRSNELDPVNHGDLI
TSMGQLQRNARDLQESVMSIRMMPMEYVFSRFPRLVRDLAGKLGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLDH
GIEMPEKRLEAGKNVVGNLILSAEHQGGNICIEVTDDGAGLNRERILAKAMSQGMAVNENMTDDEVGMLIFAPGFSTAEQ
VTDVSGRGVGMDVVKRNIQEMGGHVEIQSKQGSGTTIRILLPLTLAILDGMSVRVAGEVFILPLNAVMESLQPREEDLHP
LAGGERVLEVRGEYLPLVELWKVFDVDGAKTEATQGIVVILQSAGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAAT
ILGDGSVALIVDVSALQGLNREQRMAITAA

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain

Homologues:

Organism=Escherichia coli, GI1788197, Length=672, Percent_Identity=84.8214285714286, Blast_Score=1131, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CHEA_SALTY (P09384)

Other databases:

- EMBL:   J03611
- EMBL:   AE006468
- PIR:   A28959
- RefSeq:   NP_460878.1
- PDB:   1I5N
- PDBsum:   1I5N
- ProteinModelPortal:   P09384
- PRIDE:   P09384
- GeneID:   1253442
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1921
- HOGENOM:   HBG705053
- OMA:   QESVMAI
- ProtClustDB:   PRK10547
- BioCyc:   STYP99287:STM1921-MONOMER
- BRENDA:   2.7.13.3
- GO:   GO:0005737
- GO:   GO:0006935
- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR015162
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:1.20.120.160
- Gene3D:   G3DSA:1.10.287.560
- PRINTS:   PR00344
- SMART:   SM00260
- SMART:   SM00387
- SMART:   SM00073

Pfam domain/function: PF01584 CheW; PF09078 CheY-binding; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; SSF55874 ATP_bd_ATPase; SSF50341 CheW; SSF47384 His_kin_homodim; SSF47226 Hpt

EC number: =2.7.13.3

Molecular weight: Translated: 73014; Mature: 72883

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS50851 CHEW; PS50109 HIS_KIN; PS50894 HPT; PS00039 DEAD_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMDISDFYQTFFDEADELLADMEQHLLDLVPESPDAEQLNAIFRAAHSIKGGAGTFGFT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
ILQETTHLMENLLDEARRGEMQLNTDIINLFLETKDIMQEQLDAYKNSEEPDAASFEYIC
HHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
NALRQLALEAKGETTPAVVETAALSAAIQEESVAETESPRDESKLRIVLSRLKANEVDLL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHH
EEELGNLATLTDVVKGADSLSATLDGSVAEDDIVAVLCFVIEADQIAFEKVVAAPVEKAQ
HHHHCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKTEVAPVAPPAVVAPAAKSAAHEHHAGREKPARERESTSIRVAVEKVDQLINLVGELVI
HHCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHH
TQSMLAQRSNELDPVNHGDLITSMGQLQRNARDLQESVMSIRMMPMEYVFSRFPRLVRDL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AGKLGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLDHGIEMPEKRLEAGKNVVGNL
HHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHH
ILSAEHQGGNICIEVTDDGAGLNRERILAKAMSQGMAVNENMTDDEVGMLIFAPGFSTAE
HEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHH
QVTDVSGRGVGMDVVKRNIQEMGGHVEIQSKQGSGTTIRILLPLTLAILDGMSVRVAGEV
HHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCEEEEECEE
FILPLNAVMESLQPREEDLHPLAGGERVLEVRGEYLPLVELWKVFDVDGAKTEATQGIVV
EEEEHHHHHHHCCCCHHCCCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCHHCCCCEE
ILQSAGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAATILGDGSVALIVDVSALQGL
EEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEHHHHCC
NREQRMAITAA
CHHHCEEEECC
>Mature Secondary Structure 
SMDISDFYQTFFDEADELLADMEQHLLDLVPESPDAEQLNAIFRAAHSIKGGAGTFGFT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
ILQETTHLMENLLDEARRGEMQLNTDIINLFLETKDIMQEQLDAYKNSEEPDAASFEYIC
HHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
NALRQLALEAKGETTPAVVETAALSAAIQEESVAETESPRDESKLRIVLSRLKANEVDLL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHH
EEELGNLATLTDVVKGADSLSATLDGSVAEDDIVAVLCFVIEADQIAFEKVVAAPVEKAQ
HHHHCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKTEVAPVAPPAVVAPAAKSAAHEHHAGREKPARERESTSIRVAVEKVDQLINLVGELVI
HHCCCCCCCCCHHCCCCHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHH
TQSMLAQRSNELDPVNHGDLITSMGQLQRNARDLQESVMSIRMMPMEYVFSRFPRLVRDL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AGKLGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLDHGIEMPEKRLEAGKNVVGNL
HHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHH
ILSAEHQGGNICIEVTDDGAGLNRERILAKAMSQGMAVNENMTDDEVGMLIFAPGFSTAE
HEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHH
QVTDVSGRGVGMDVVKRNIQEMGGHVEIQSKQGSGTTIRILLPLTLAILDGMSVRVAGEV
HHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCEEEEECEE
FILPLNAVMESLQPREEDLHPLAGGERVLEVRGEYLPLVELWKVFDVDGAKTEATQGIVV
EEEEHHHHHHHCCCCHHCCCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCHHCCCCEE
ILQSAGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAATILGDGSVALIVDVSALQGL
EEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEHHHHCC
NREQRMAITAA
CHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3278311; 11677609