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The map label for this gene is pabB

Identifier: 16765165

GI number: 16765165

Start: 1921169

End: 1922533

Strand: Direct

Name: pabB

Synonym: STM1824

Alternate gene names: 16765165

Gene position: 1921169-1922533 (Clockwise)

Preceding gene: 16765163

Following gene: 16765166

Centisome position: 39.55

GC content: 55.24

Gene sequence:

>1365_bases
ATGATGAAGACGTTATCTCCCACTGTTATCACCTTACCCTGGCGTCCGGACGCCGCTGAACACTATTTTGCGCCCGTAAA
CCATTTGCCCTGGGCGATGCTGCTGCATTCAGGTGATGCTATTCATCCCTATAACCGTTTTGATATTCTGGTCGCCGATC
CTGTCACCACACTGACCACGCGCGCGCAGGAAACCACGGTATGTACTGCGCGCACGACTACCGTCACTCTCGACGATCCG
TTACACGTTTTGCAGACTCAACTGGAGGCGCTGCCTTTTCATCCTCAGCCTGACCCTGACTTACCCTTTCAGGGCGGCGC
GCTGGGTCTGTTTGGTTATGATTTAGGGCGGCGTTTCGAAATTTTGCCCGATACTGCCGCGCGCGATATCGCTTTACCCG
ATATGGCGATTGGCCTTTACGACTGGGCGCTGATTGTCGATCACCAAAAACAGGTGGTGTCGCTGATAAGCTATCACGAT
GCAGACGCCCGATATCGCTGGCTCACCAGCCAGCGCGCGCCGACCCGCACGCCCTTCAGGCTTACCTCAGCCTGGCAATC
CAATATGACGCGTTGCGAGTATGGCGAGAAGTTTCGTCAGGTGCAGGCCTGGCTGCACAGCGGGGACTGCTATCAGGTCA
ATCTTTCCCAGCGTTTTCAGGCGAGCTACGAGGGTGATGAATGGCAGGCTTTCGAACGCCTTAACCGCGCCAATCGCGCC
CCGTTCAGCGCCTTTCTTCGTTTACATGACGGCGCCATATTGAGCCTTTCTCCCGAGCGTTTTATCCAACTGGAGAATGG
TCATATCCAGACGCGCCCGATCAAAGGTACGCTTCCACGGCTTAACGATCCGCAGGCGGATCGTCAGCAGGCGCAGAAAC
TGGCTAATTCAATGAAAGATCGCGCTGAAAATTTGATGATTGTCGATTTGATGCGTAACGATATTGGCCGGGTCGCCGTA
CCAGGTTCGGTGAAAGTGCCGGAACTGTTCGTCGTCGAACCATTTCCTGCCGTTCACCATCTGGTTAGCACCATTACCGC
CCGTTTACCGGACTCGCTTCATGCTACCGACCTGCTGCGCGCGGCTTTCCCCGGCGGCTCCATTACCGGCGCGCCTAAAG
TGCGGGCAATGGAAATTATCGACGAACTGGAGCCGCAGCGACGCAACGCCTGGTGCGGTAGCATCGGTTATCTGAGTTTC
TGCGGCAAGATGGATACCAGTATTACTATCCGCACCGTCACGGCAACGCAGGGCCAACTCTATTGCTCAGCCGGCGGCGG
TATCGTGGCCGATAGCAACGAAGAAGCGGAATATCAGGAAACTTTTGATAAAGTTAATCGTATCCTGCACCCACTGGAGA
ACTAA

Upstream 100 bases:

>100_bases
GAAGGTAAACCTGCAAACATGATTAACTCCTGCTAAATTGTTAGCGCTAATTATTTCACGCTACCCGGCGGTAAGCCAGT
AGTGTTGTAACGAGTCAGGA

Downstream 100 bases:

>100_bases
TACGTGGATACCAGCCGTCTGACGCTCGATCATTTCTTATCGCGCTTTCAGCTTTTGCGCCCGCAGATGACTCATGAAAC
GTTAAATCAACGTCAGGCCG

Product: para-aminobenzoate synthase component I

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MMKTLSPTVITLPWRPDAAEHYFAPVNHLPWAMLLHSGDAIHPYNRFDILVADPVTTLTTRAQETTVCTARTTTVTLDDP
LHVLQTQLEALPFHPQPDPDLPFQGGALGLFGYDLGRRFEILPDTAARDIALPDMAIGLYDWALIVDHQKQVVSLISYHD
ADARYRWLTSQRAPTRTPFRLTSAWQSNMTRCEYGEKFRQVQAWLHSGDCYQVNLSQRFQASYEGDEWQAFERLNRANRA
PFSAFLRLHDGAILSLSPERFIQLENGHIQTRPIKGTLPRLNDPQADRQQAQKLANSMKDRAENLMIVDLMRNDIGRVAV
PGSVKVPELFVVEPFPAVHHLVSTITARLPDSLHATDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSF
CGKMDTSITIRTVTATQGQLYCSAGGGIVADSNEEAEYQETFDKVNRILHPLEN

Sequences:

>Translated_454_residues
MMKTLSPTVITLPWRPDAAEHYFAPVNHLPWAMLLHSGDAIHPYNRFDILVADPVTTLTTRAQETTVCTARTTTVTLDDP
LHVLQTQLEALPFHPQPDPDLPFQGGALGLFGYDLGRRFEILPDTAARDIALPDMAIGLYDWALIVDHQKQVVSLISYHD
ADARYRWLTSQRAPTRTPFRLTSAWQSNMTRCEYGEKFRQVQAWLHSGDCYQVNLSQRFQASYEGDEWQAFERLNRANRA
PFSAFLRLHDGAILSLSPERFIQLENGHIQTRPIKGTLPRLNDPQADRQQAQKLANSMKDRAENLMIVDLMRNDIGRVAV
PGSVKVPELFVVEPFPAVHHLVSTITARLPDSLHATDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSF
CGKMDTSITIRTVTATQGQLYCSAGGGIVADSNEEAEYQETFDKVNRILHPLEN
>Mature_454_residues
MMKTLSPTVITLPWRPDAAEHYFAPVNHLPWAMLLHSGDAIHPYNRFDILVADPVTTLTTRAQETTVCTARTTTVTLDDP
LHVLQTQLEALPFHPQPDPDLPFQGGALGLFGYDLGRRFEILPDTAARDIALPDMAIGLYDWALIVDHQKQVVSLISYHD
ADARYRWLTSQRAPTRTPFRLTSAWQSNMTRCEYGEKFRQVQAWLHSGDCYQVNLSQRFQASYEGDEWQAFERLNRANRA
PFSAFLRLHDGAILSLSPERFIQLENGHIQTRPIKGTLPRLNDPQADRQQAQKLANSMKDRAENLMIVDLMRNDIGRVAV
PGSVKVPELFVVEPFPAVHHLVSTITARLPDSLHATDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSF
CGKMDTSITIRTVTATQGQLYCSAGGGIVADSNEEAEYQETFDKVNRILHPLEN

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family

Homologues:

Organism=Escherichia coli, GI1788114, Length=453, Percent_Identity=76.3796909492274, Blast_Score=715, Evalue=0.0,
Organism=Escherichia coli, GI1787518, Length=404, Percent_Identity=31.6831683168317, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1786809, Length=225, Percent_Identity=27.5555555555556, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=438, Percent_Identity=30.5936073059361, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324361, Length=398, Percent_Identity=26.8844221105528, Blast_Score=144, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PABB_SALTY (P12680)

Other databases:

- EMBL:   M22079
- EMBL:   AE006468
- PIR:   A31132
- RefSeq:   NP_460780.1
- ProteinModelPortal:   P12680
- SMR:   P12680
- PRIDE:   P12680
- GeneID:   1253343
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1824
- NMPDR:   fig|99287.1.peg.1765
- HOGENOM:   HBG507440
- OMA:   HNRFDIL
- ProtClustDB:   PRK15465
- BioCyc:   STYP99287:STM1824-MONOMER
- BRENDA:   2.6.1.85
- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802
- Gene3D:   G3DSA:3.60.120.10
- PANTHER:   PTHR11236
- PRINTS:   PR00095
- TIGRFAMs:   TIGR00553

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind; SSF56322 TRPE_1_chor_bd

EC number: =2.6.1.85

Molecular weight: Translated: 50979; Mature: 50979

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTLSPTVITLPWRPDAAEHYFAPVNHLPWAMLLHSGDAIHPYNRFDILVADPVTTLTT
CCCCCCCCEEEECCCCCCCHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCHHHHHC
RAQETTVCTARTTTVTLDDPLHVLQTQLEALPFHPQPDPDLPFQGGALGLFGYDLGRRFE
CCCCCEEEEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEE
ILPDTAARDIALPDMAIGLYDWALIVDHQKQVVSLISYHDADARYRWLTSQRAPTRTPFR
ECCCCCCCCCCCCCHHHHHHHEEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEE
LTSAWQSNMTRCEYGEKFRQVQAWLHSGDCYQVNLSQRFQASYEGDEWQAFERLNRANRA
EHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHCCCC
PFSAFLRLHDGAILSLSPERFIQLENGHIQTRPIKGTLPRLNDPQADRQQAQKLANSMKD
CHHHHHHHCCCEEEEECHHHEEEECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RAENLMIVDLMRNDIGRVAVPGSVKVPELFVVEPFPAVHHLVSTITARLPDSLHATDLLR
HHCCEEEEEEHHCCCCCEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHH
AAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGKMDTSITIRTVTATQGQL
HHCCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHCCCCCEEEEEEEEECCCEE
YCSAGGGIVADSNEEAEYQETFDKVNRILHPLEN
EEECCCCEEECCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMKTLSPTVITLPWRPDAAEHYFAPVNHLPWAMLLHSGDAIHPYNRFDILVADPVTTLTT
CCCCCCCCEEEECCCCCCCHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCHHHHHC
RAQETTVCTARTTTVTLDDPLHVLQTQLEALPFHPQPDPDLPFQGGALGLFGYDLGRRFE
CCCCCEEEEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEE
ILPDTAARDIALPDMAIGLYDWALIVDHQKQVVSLISYHDADARYRWLTSQRAPTRTPFR
ECCCCCCCCCCCCCHHHHHHHEEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEE
LTSAWQSNMTRCEYGEKFRQVQAWLHSGDCYQVNLSQRFQASYEGDEWQAFERLNRANRA
EHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHCCCC
PFSAFLRLHDGAILSLSPERFIQLENGHIQTRPIKGTLPRLNDPQADRQQAQKLANSMKD
CHHHHHHHCCCEEEEECHHHEEEECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RAENLMIVDLMRNDIGRVAVPGSVKVPELFVVEPFPAVHHLVSTITARLPDSLHATDLLR
HHCCEEEEEEHHCCCCCEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHH
AAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGKMDTSITIRTVTATQGQL
HHCCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHCCCCCEEEEEEEEECCCEE
YCSAGGGIVADSNEEAEYQETFDKVNRILHPLEN
EEECCCCEEECCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3057324; 11677609; 2251281