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The map label for this gene is lldD [C]

Identifier: 16764964

GI number: 16764964

Start: 1707842

End: 1709044

Strand: Reverse

Name: lldD [C]

Synonym: STM1620

Alternate gene names: 16764964

Gene position: 1709044-1707842 (Counterclockwise)

Preceding gene: 16764965

Following gene: 16764955

Centisome position: 35.18

GC content: 48.3

Gene sequence:

>1203_bases
ATGAAAACTCATCACCTCATTCGGGTAGTGGCCTCGCTGGCAATGTTGGCAACATCAGGCCTGGCTTATGCTGAAGAGTA
CAAAGCCAGTACGGACGAAAAAGCAATAAAAATGACGAACGTAGCCTCCCTGGAAGCGCGCGTTCAGGCCAAAATGGAGA
AAGGGGCATTTGGTTATATTCGCGGTGGAGCCGAAGATGAGAATAACCTTCGCAGCAACACCGAAAGCTTTGACAAAAAA
TATATTATGCCGCGCGTATTACAGGGCATTGAGTTAAAAGAGATCGATTTATCAACGCAGCTACTGGGTATTCCGCTTAA
AACGCCTATAATCCAGGCACCGATGGCGGCGCAGGGCCTGGCCCACGCCTCCGGAGAGTTGGCGACGGCGAAAGGCATGG
CGCAGGTCGGTTCGATTTTCTCGTTGAGCACCTATGGCAACAAGACCATCGAAGAGGTGGCTAACGTTTCCGGGAAAAAT
CCGTTCTTCTTCCAGCTTTATATGAGTAAGAATAATCAATTTAACGAATTTATTCTTGCACAAGCGGTAAAGCATGGCGC
TAAAGCGATTATTCTGACCGTAGATTCGCCTGTCGGTGGTTATCGGGAAGAAGATATTAAAAATAACTTCCAGTTCCCGT
TGGGCTTTGCAAACCTGGAAATGTTCGCCAGAAAAAATGACGATGGTTCAAAAACTGGCAAAGGAGCAGGGATAAGTGAA
ATTTACGCGCAGGCTAAACAAGCCTTTACGCCGGAGGATATTGCCTATGTACATCGTATTTCCGGTCTGCCGGTTATCGT
AAAAGGCATTCAGTCGCCGGAGGATGCTGAAATTGCTATCCAGGCCGGGGCCGCAGGAATATGGGTTTCTAACCATGGTG
GCCGTCAATTAGACAGCGGGCCGTCCTCATTCGATATGCTTCCTGCGATTGCAAAAGTCGTCAACAAGCGAGTGCCTGTT
ATTTTTGACAGTGGAGTACGCCGTGGTTCGCACATATTCAAAGCGTTAGCCAGCGGGGCGGATATTGTGGCGGTTGGCCG
GCCTGTATTATACGGTCTTAATCTTGGCGGCGCTCAGGGTGTGGCATCAGTGATTGAACAGCTAAACAAAGAGCTGACAA
TTAACATGATGTTGGGTGGCGCCAGAAATATTGAACAAGTGAAAACGACACGCTTGTTAACTGAAAAAGATCTGCCCCAG
TAA

Upstream 100 bases:

>100_bases
GCACCCAGTGGGGGATAGATTATCTGGTCGATATGGGGATGACGAAAGTTGTCGATATAAAAATCCAGGCAGAAGCGGTT
AAGCAATAAAGGGAATAATG

Downstream 100 bases:

>100_bases
TATAAAGGTCGGGTACTATACCCGACCTTTTCCTGTATGATTTCCCTCAACAACGCTTTCGGTAGAAAATGACGCGCTCT
GTTTCCTCAAATCCTAACGC

Product: oxidase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQAKMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKRVPV
IFDSGVRRGSHIFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ

Sequences:

>Translated_400_residues
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQAKMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKRVPV
IFDSGVRRGSHIFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ
>Mature_400_residues
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQAKMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKRVPV
IFDSGVRRGSHIFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=357, Percent_Identity=36.4145658263305, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI54234014, Length=355, Percent_Identity=31.2676056338028, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI7705393, Length=355, Percent_Identity=31.2676056338028, Blast_Score=200, Evalue=2e-51,
Organism=Escherichia coli, GI1790033, Length=366, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI193208036, Length=349, Percent_Identity=36.1031518624642, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI32566217, Length=257, Percent_Identity=35.0194552529183, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=372, Percent_Identity=30.1075268817204, Blast_Score=160, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281363140, Length=364, Percent_Identity=35.7142857142857, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI78707190, Length=364, Percent_Identity=35.7142857142857, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI78707188, Length=363, Percent_Identity=35.5371900826446, Blast_Score=224, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 43025; Mature: 43025

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQAKMEKGAFGYI
CCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHCCCCEEE
RGGAEDENNLRSNTESFDKKYIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGL
ECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHEECCCCCCCHHCCCHHHHHH
AHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKNPFFFQLYMSKNNQFNEFILA
HHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHH
QAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
HHHHCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCHHH
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSG
HHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCCC
PSSFDMLPAIAKVVNKRVPVIFDSGVRRGSHIFKALASGADIVAVGRPVLYGLNLGGAQG
CCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCHHH
VASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQAKMEKGAFGYI
CCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHCCCCEEE
RGGAEDENNLRSNTESFDKKYIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGL
ECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHEECCCCCCCHHCCCHHHHHH
AHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKNPFFFQLYMSKNNQFNEFILA
HHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHH
QAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
HHHHCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCHHH
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSG
HHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCCC
PSSFDMLPAIAKVVNKRVPVIFDSGVRRGSHIFKALASGADIVAVGRPVLYGLNLGGAQG
CCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCHHH
VASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]