Click here to switch to the map view.

The map label for this gene is dcp

Identifier: 16764857

GI number: 16764857

Start: 1589687

End: 1591729

Strand: Direct

Name: dcp

Synonym: STM1512

Alternate gene names: 16764857

Gene position: 1589687-1591729 (Clockwise)

Preceding gene: 16764853

Following gene: 16764858

Centisome position: 32.73

GC content: 53.74

Gene sequence:

>2043_bases
ATGTCGACGAATCCTTTGTTAGACCAGAGTATGTTGCCTTATCAGGCACCGCGTTTTGATCGGATCAAAGATTGCCATTA
TCGTCCTGCTTTTGATGAGGGCGTGCGGCAAAAACGCGTGGAAATCGAGGCCATCGTCAATCATCCGGCGGCCCCTGACT
TTACGAATACGCTTCTGGCGCTGGAGCAAAGTGGGGCGCTTCTGTCACGCGTCACCAGCGTTTTTTTCGCGATGACGGCC
GCGCACACTAACGATGAACTCCAGCGGTTGGATGAGGCCTTTTCTGCCGAGCTGGCGGCGCTCTCCAACGATATTTATCT
GAATAGCGCGTTATTCGCTCGCGTGGATGCCGTCTGGCAACAGCGTCACTCACTGGGGCTGGATGATGAGTCGCTACGGT
TGGTCGATGTGATCCATCAGCGTTTTGTGTTGGCAGGCGCGCAGCTTGCCGAAGAGGATAAAGCGCGACTGAAGGTATTG
AATACTGAATCCGCGACCTTAATGAGTCAGTTTAATCAGCGTCTGCTGGCGGCAAGTAAAGCGGGCGGGCTGGCGGTAGA
TGACGCGCATTGCCTGGCAGGATTAAGCCCGGAAGAAATGACCGTCGCTGCTGAAGCGGCGCGTGAAAAAGGCCTGGAGG
AGCGCTGGTTCATTCCGCTCCTTAATACGACGCAACAGCCTGCGCTTGCTACGCTGCGCGATCGCCAGACCCGCGAAAAT
TTATTCGCAGCGTCATGGACTCGGGCGGAAAAAGGAGATGCCCACGATACCCGCGCTATCGTTCAGCGTCTGGTAGAGAT
TCGTCGCTGTCAGGCAAAACTACTGGGTTTCCCCAATTATGCCGCATGGAAAATGGCCGATCAGATGGCGAAAACGCCGC
AAGCCGCACTGAGCTTTATGCGTGGCATTGTGCCGCCAGCGCGTCAGCGGGTACTCAATGAACAGGCGGAAATTCAGAAC
GTCATTGATGGTGAGCAGGGCGGCTACACCGTTCAGGCCTGGGACTGGATGTTCTATGCCGAACAGGTACGGCGGGAAAA
ATATGCGTTAGATGAAGCGCAACTGAAGCCCTATTTTGCCTTAAATACGGTGTTGCAAGAGGGGGTTTTCTGGACCGCCA
ACCAGCTATTCGGCATCACCTTCGTCGAGCGTTTTGACATTCCGGTGTATCACCCTGATGTTCGGGTGTGGGAGATTTTC
GATTCCGATGGTGTCGGCATGGCGTTATTTTATGGCGACTTCTTCGCGCGGGACTCGAAAAGCGGCGGCGCGTGGATGGG
GAATTTTGTCGAGCAATCCACACTCAATGAAACCCGGCCCGTTATATACAACGTATGTAACTATCAGAAACCTGTTGATG
GGCAGCCTGCATTACTGCTTTGGGACGACGTTATTACACTCTTCCATGAGTTTGGTCATACGTTGCATGGTTTGTTTGCC
GTCCAGCGTTATGCCACGCTTTCAGGTACCAATACGCCCCGCGACTTTGTCGAGTTTCCCTCCCAGATTAATGAGCATTG
GGCGAGCCATCCACGTGTGTTCGAACGCTACGCGCGTCATGTCGACAGCGGTGAAAAAATGCCTGCTGATTTACAGGAAA
GAATGCGCAAGGCGAGTTTATTTAATAAAGGTTACGATATGACTGAATTGCTCGGCGCCGCATTGCTGGATATGCGCTGG
CATATGCTGGAGGAGAGCGTAGCAGAGCAGTCTGTCGCTGAGTTCGAGCAGCAGGCGCTGGCCGCCGAGCATCTTGATTT
ACCGGCAGTGCCGCCCCGCTATCGCAGCAGTTATTTTGCCCATATCTTCGGCGGCGGCTATGCAGCGGGATACTACGCCT
ATCTGTGGACGCAAATGTTAGCGGATGACGGTTATCAATGGTTTGTAGAGCAGGGCGGCCTGACGCGTGAAAACGGGCAG
CGTTTTCGTGATGCTATCCTTGCCCGGGGGAATAGTACTGATTTAGAAACGCTTTATTCAGCCTGGCGTGGACATGAACC
GCATATTGACCCCATGTTGCAATATCGTGGGCTCGATCGCTAA

Upstream 100 bases:

>100_bases
AGCACGCGGCGTTTATGAAAGGGTAATCCTGGTTAACACGGTTGCGGTCAGCATAGGGGGAAGCTTACTCTTATGATCAA
CCTATTTTCAGGAGTGAAAA

Downstream 100 bases:

>100_bases
GCTGATACGGTTGTTCGGCACTGTCGAACAACCGCCTGAAAATGAATCCTGAACTTCTGATGACAGCCAGTTAAATTTAT
GGGGTTAAGTTGTCTGAATA

Product: dipeptidyl carboxypeptidase II

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MSTNPLLDQSMLPYQAPRFDRIKDCHYRPAFDEGVRQKRVEIEAIVNHPAAPDFTNTLLALEQSGALLSRVTSVFFAMTA
AHTNDELQRLDEAFSAELAALSNDIYLNSALFARVDAVWQQRHSLGLDDESLRLVDVIHQRFVLAGAQLAEEDKARLKVL
NTESATLMSQFNQRLLAASKAGGLAVDDAHCLAGLSPEEMTVAAEAAREKGLEERWFIPLLNTTQQPALATLRDRQTREN
LFAASWTRAEKGDAHDTRAIVQRLVEIRRCQAKLLGFPNYAAWKMADQMAKTPQAALSFMRGIVPPARQRVLNEQAEIQN
VIDGEQGGYTVQAWDWMFYAEQVRREKYALDEAQLKPYFALNTVLQEGVFWTANQLFGITFVERFDIPVYHPDVRVWEIF
DSDGVGMALFYGDFFARDSKSGGAWMGNFVEQSTLNETRPVIYNVCNYQKPVDGQPALLLWDDVITLFHEFGHTLHGLFA
VQRYATLSGTNTPRDFVEFPSQINEHWASHPRVFERYARHVDSGEKMPADLQERMRKASLFNKGYDMTELLGAALLDMRW
HMLEESVAEQSVAEFEQQALAAEHLDLPAVPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQ
RFRDAILARGNSTDLETLYSAWRGHEPHIDPMLQYRGLDR

Sequences:

>Translated_680_residues
MSTNPLLDQSMLPYQAPRFDRIKDCHYRPAFDEGVRQKRVEIEAIVNHPAAPDFTNTLLALEQSGALLSRVTSVFFAMTA
AHTNDELQRLDEAFSAELAALSNDIYLNSALFARVDAVWQQRHSLGLDDESLRLVDVIHQRFVLAGAQLAEEDKARLKVL
NTESATLMSQFNQRLLAASKAGGLAVDDAHCLAGLSPEEMTVAAEAAREKGLEERWFIPLLNTTQQPALATLRDRQTREN
LFAASWTRAEKGDAHDTRAIVQRLVEIRRCQAKLLGFPNYAAWKMADQMAKTPQAALSFMRGIVPPARQRVLNEQAEIQN
VIDGEQGGYTVQAWDWMFYAEQVRREKYALDEAQLKPYFALNTVLQEGVFWTANQLFGITFVERFDIPVYHPDVRVWEIF
DSDGVGMALFYGDFFARDSKSGGAWMGNFVEQSTLNETRPVIYNVCNYQKPVDGQPALLLWDDVITLFHEFGHTLHGLFA
VQRYATLSGTNTPRDFVEFPSQINEHWASHPRVFERYARHVDSGEKMPADLQERMRKASLFNKGYDMTELLGAALLDMRW
HMLEESVAEQSVAEFEQQALAAEHLDLPAVPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQ
RFRDAILARGNSTDLETLYSAWRGHEPHIDPMLQYRGLDR
>Mature_679_residues
STNPLLDQSMLPYQAPRFDRIKDCHYRPAFDEGVRQKRVEIEAIVNHPAAPDFTNTLLALEQSGALLSRVTSVFFAMTAA
HTNDELQRLDEAFSAELAALSNDIYLNSALFARVDAVWQQRHSLGLDDESLRLVDVIHQRFVLAGAQLAEEDKARLKVLN
TESATLMSQFNQRLLAASKAGGLAVDDAHCLAGLSPEEMTVAAEAAREKGLEERWFIPLLNTTQQPALATLRDRQTRENL
FAASWTRAEKGDAHDTRAIVQRLVEIRRCQAKLLGFPNYAAWKMADQMAKTPQAALSFMRGIVPPARQRVLNEQAEIQNV
IDGEQGGYTVQAWDWMFYAEQVRREKYALDEAQLKPYFALNTVLQEGVFWTANQLFGITFVERFDIPVYHPDVRVWEIFD
SDGVGMALFYGDFFARDSKSGGAWMGNFVEQSTLNETRPVIYNVCNYQKPVDGQPALLLWDDVITLFHEFGHTLHGLFAV
QRYATLSGTNTPRDFVEFPSQINEHWASHPRVFERYARHVDSGEKMPADLQERMRKASLFNKGYDMTELLGAALLDMRWH
MLEESVAEQSVAEFEQQALAAEHLDLPAVPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQR
FRDAILARGNSTDLETLYSAWRGHEPHIDPMLQYRGLDR

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family

Homologues:

Organism=Homo sapiens, GI4507491, Length=603, Percent_Identity=26.6998341625207, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI14149738, Length=554, Percent_Identity=27.7978339350181, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI156105687, Length=650, Percent_Identity=22.7692307692308, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1787819, Length=678, Percent_Identity=78.9085545722714, Blast_Score=1089, Evalue=0.0,
Organism=Escherichia coli, GI1789913, Length=685, Percent_Identity=32.4087591240876, Blast_Score=337, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319793, Length=660, Percent_Identity=24.8484848484848, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322715, Length=447, Percent_Identity=23.0425055928412, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21356111, Length=571, Percent_Identity=24.1681260945709, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI20129717, Length=397, Percent_Identity=25.9445843828715, Blast_Score=120, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCP_SALTY (P27236)

Other databases:

- EMBL:   M84575
- EMBL:   AE006468
- PIR:   A42297
- RefSeq:   NP_460472.1
- ProteinModelPortal:   P27236
- SMR:   P27236
- MEROPS:   M03.005
- PRIDE:   P27236
- GeneID:   1253030
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1512
- NMPDR:   fig|99287.1.peg.1462
- HOGENOM:   HBG678447
- OMA:   GYSASYY
- ProtClustDB:   PRK10280
- BioCyc:   STYP99287:STM1512-MONOMER
- BRENDA:   3.4.15.5
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR001567

Pfam domain/function: PF01432 Peptidase_M3

EC number: =3.4.15.5

Molecular weight: Translated: 77262; Mature: 77131

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 470-470

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNPLLDQSMLPYQAPRFDRIKDCHYRPAFDEGVRQKRVEIEAIVNHPAAPDFTNTLLA
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LEQSGALLSRVTSVFFAMTAAHTNDELQRLDEAFSAELAALSNDIYLNSALFARVDAVWQ
HHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHH
QRHSLGLDDESLRLVDVIHQRFVLAGAQLAEEDKARLKVLNTESATLMSQFNQRLLAASK
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHHHHHC
AGGLAVDDAHCLAGLSPEEMTVAAEAAREKGLEERWFIPLLNTTQQPALATLRDRQTREN
CCCCEECCHHHHCCCCHHHHHHHHHHHHHCCCCHHEEEECCCCCCCCHHHHHHHHHHHHH
LFAASWTRAEKGDAHDTRAIVQRLVEIRRCQAKLLGFPNYAAWKMADQMAKTPQAALSFM
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
RGIVPPARQRVLNEQAEIQNVIDGEQGGYTVQAWDWMFYAEQVRREKYALDEAQLKPYFA
HHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHCCHHHH
LNTVLQEGVFWTANQLFGITFVERFDIPVYHPDVRVWEIFDSDGVGMALFYGDFFARDSK
HHHHHHCCCEEEHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCEEEEEHHHHHHCCCC
SGGAWMGNFVEQSTLNETRPVIYNVCNYQKPVDGQPALLLWDDVITLFHEFGHTLHGLFA
CCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
VQRYATLSGTNTPRDFVEFPSQINEHWASHPRVFERYARHVDSGEKMPADLQERMRKASL
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FNKGYDMTELLGAALLDMRWHMLEESVAEQSVAEFEQQALAAEHLDLPAVPPRYRSSYFA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEE
HIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQRFRDAILARGNSTDLETLYS
HHHCCCHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
AWRGHEPHIDPMLQYRGLDR
HHCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure 
STNPLLDQSMLPYQAPRFDRIKDCHYRPAFDEGVRQKRVEIEAIVNHPAAPDFTNTLLA
CCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LEQSGALLSRVTSVFFAMTAAHTNDELQRLDEAFSAELAALSNDIYLNSALFARVDAVWQ
HHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHH
QRHSLGLDDESLRLVDVIHQRFVLAGAQLAEEDKARLKVLNTESATLMSQFNQRLLAASK
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHHHHHC
AGGLAVDDAHCLAGLSPEEMTVAAEAAREKGLEERWFIPLLNTTQQPALATLRDRQTREN
CCCCEECCHHHHCCCCHHHHHHHHHHHHHCCCCHHEEEECCCCCCCCHHHHHHHHHHHHH
LFAASWTRAEKGDAHDTRAIVQRLVEIRRCQAKLLGFPNYAAWKMADQMAKTPQAALSFM
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
RGIVPPARQRVLNEQAEIQNVIDGEQGGYTVQAWDWMFYAEQVRREKYALDEAQLKPYFA
HHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHCCHHHH
LNTVLQEGVFWTANQLFGITFVERFDIPVYHPDVRVWEIFDSDGVGMALFYGDFFARDSK
HHHHHHCCCEEEHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCEEEEEHHHHHHCCCC
SGGAWMGNFVEQSTLNETRPVIYNVCNYQKPVDGQPALLLWDDVITLFHEFGHTLHGLFA
CCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
VQRYATLSGTNTPRDFVEFPSQINEHWASHPRVFERYARHVDSGEKMPADLQERMRKASL
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FNKGYDMTELLGAALLDMRWHMLEESVAEQSVAEFEQQALAAEHLDLPAVPPRYRSSYFA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEE
HIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGQRFRDAILARGNSTDLETLYS
HHHCCCHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
AWRGHEPHIDPMLQYRGLDR
HHCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537804; 11677609