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The map label for this gene is mlc [H]

Identifier: 16764833

GI number: 16764833

Start: 1565101

End: 1566321

Strand: Direct

Name: mlc [H]

Synonym: STM1488

Alternate gene names: 16764833

Gene position: 1565101-1566321 (Clockwise)

Preceding gene: 16764832

Following gene: 16764834

Centisome position: 32.22

GC content: 51.92

Gene sequence:

>1221_bases
GTGGTTGCTGATAGTCAGCCTGGGCATATCGATCAAATTAAGCAGACCAATGCTGGCGCAGTGTATCGCCTGATTGATCA
GCTCGGACCGGTATCGCGAATTGACCTGTCTCGTCTGGCGCAGTTGGCGCCTGCCAGTATTACGAAAATTGTTCGCGAAA
TGCTGGAAGCGCATTTGGTTCAGGAACTTGAAATTAAAGAGGCGGGCAGTCGTGGACGTCCCGCCGTCGGGCTGATGGTG
GAAACGGAAGCCTGGCACTATTTATCTATTCGTATTAGCCGTGGCGAAATTTTCCTTGCACTGCGCGATCTTAGCAGCAA
ACTGGTGGTAGAAGAGTGTCTGCCGCTGCCGTTAACCGAAGCCACGCCGTTGCTTGAGCGAATTATTACGCACGTTGATC
GGTTTTTTACCCGCCATCAGCAGAAACTGGAGCGTCTGACATCCATTGCCATTACGTTACCGGGCATTATCGATACCGAA
AACGGCGTTGTGCACCGGATGCCGTATTACGAAGATGTCAAAGAGATGCCTTTGGGAGATTCGCTGGAGCGGCACACTGG
CGTACCGGTTTACATTCAGCATGATATTAGCGCCTGGACGATGGCAGAGGCGCTTTTTGGCGCTTCACGCGGCGCGCGCG
ACGTTATCCAGGTGGTGATTGATCATAATGTGGGGGCGGGCGTTATCACCGACGGTCATTTGCTTCATGCGGGTAGTAGC
AGTCTGGTAGAGATTGGGCATACCCAGGTCGATCCTTATGGTAAGCGCTGTTATTGCGGTAATCATGGCTGTCTGGAGAC
CATCGCCAGCGTCGATAGCGTGCTGGAACTTACGCAGCTTCGGCTTAATCAGTCGATGAGTTCAATGTTGCACGGCCAGC
CGTTAACGGTAGATTCACTGTGTCAGGCGGCGATGCAGGGAGATCTATTAGCAAAAGATATTATTAGCGGCGTTGGCGCG
CATGTCGGACGCATTCTGGCTATCATGGTGAATTTATTTAATCCGCAAAAAATTCTTATTGGTTCGCCGCTAAGTAAAGC
GGCTGATATCCTTTTTCCGGCCATTGCTGACAGTATCCGTCAACAGGCGCTGCCCGCCTACAGCAGGAATACGGTTGTGG
AAAGCACGCAGTTTACCAACCAGGGCACGATGGCCGGGGCGGCGTTGGTAAAAGACGCGATGTATAACGGCTCTTTGTTG
ATTCGTCTATTACAGGGTTAA

Upstream 100 bases:

>100_bases
AGTTAATCACACGGCTAAGCAAAAAGTTGACGGCGAGTATTGAAGTGTTTCACCATAGCACACAGATTATTTCGGAGCGC
GAAAATAAAGGGAGTGAGCG

Downstream 100 bases:

>100_bases
CATTTTTTAACTGTTGTACAAAAATTTGCGCTAACTCAAGCTGATTGCCCTTGCCATATCTTAGACTTTCTCCACTGTAT
TATTTTCCTGGCTTATATTT

Product: pts operon transcriptional repressor

Products: NA

Alternate protein names: Making large colonies protein [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLVQELEIKEAGSRGRPAVGLMV
ETEAWHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTEATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTE
NGVVHRMPYYEDVKEMPLGDSLERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGA
HVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAALVKDAMYNGSLL
IRLLQG

Sequences:

>Translated_406_residues
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLVQELEIKEAGSRGRPAVGLMV
ETEAWHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTEATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTE
NGVVHRMPYYEDVKEMPLGDSLERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGA
HVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAALVKDAMYNGSLL
IRLLQG
>Mature_406_residues
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLVQELEIKEAGSRGRPAVGLMV
ETEAWHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTEATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTE
NGVVHRMPYYEDVKEMPLGDSLERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGA
HVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAALVKDAMYNGSLL
IRLLQG

Specific function: Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=227, Percent_Identity=26.431718061674, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI298566315, Length=227, Percent_Identity=26.431718061674, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI190014632, Length=227, Percent_Identity=26.431718061674, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4885285, Length=227, Percent_Identity=26.431718061674, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787878, Length=406, Percent_Identity=91.1330049261084, Blast_Score=766, Evalue=0.0,
Organism=Escherichia coli, GI1786891, Length=401, Percent_Identity=39.9002493765586, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI87082127, Length=372, Percent_Identity=22.8494623655914, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1787363, Length=327, Percent_Identity=24.7706422018349, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081733, Length=301, Percent_Identity=24.2524916943522, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 44236; Mature: 44236

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLV
CCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
QELEIKEAGSRGRPAVGLMVETEAWHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTE
HHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEECCEEEEEEEHHHHHHHHHHHCCCCCCH
ATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTENGVVHRMPYYEDVKEMPLGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCEEECCCHHHHHHCCCCC
SLERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
CHHHHCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCEEEECCCC
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHGQPLTVDSL
CCEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
CQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHH
QQALPAYSRNTVVESTQFTNQGTMAGAALVKDAMYNGSLLIRLLQG
HHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCHHHHEEECC
>Mature Secondary Structure
MVADSQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLV
CCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
QELEIKEAGSRGRPAVGLMVETEAWHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTE
HHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEECCEEEEEEEHHHHHHHHHHHCCCCCCH
ATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTENGVVHRMPYYEDVKEMPLGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCEEECCCHHHHHHCCCCC
SLERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
CHHHHCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCEEEECCCC
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHGQPLTVDSL
CCEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
CQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHH
QQALPAYSRNTVVESTQFTNQGTMAGAALVKDAMYNGSLLIRLLQG
HHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7766024; 9097039; 9278503 [H]