Click here to switch to the map view.

The map label for this gene is tppB [H]

Identifier: 16764800

GI number: 16764800

Start: 1526450

End: 1527955

Strand: Reverse

Name: tppB [H]

Synonym: STM1452

Alternate gene names: 16764800

Gene position: 1527955-1526450 (Counterclockwise)

Preceding gene: 16764801

Following gene: 16764799

Centisome position: 31.46

GC content: 53.05

Gene sequence:

>1506_bases
GTGTCTACTGCAAACAAAAAACCAACTGAAAGCGTCAGTTTGAACGCTTTCAAACAACCGAAGGCGTTCTATCTCATCTT
CTCGATAGAGTTATGGGAGCGTTTTGGTTATTACGGCCTGCAAGGCATTATGGCCGTCTACCTGGTAAAACAACTGGGTA
TGTCAGAAGCGGATTCCATCACCCTTTTCTCTTCCTTCAGTGCACTGGTGTACGGCCTGGTCGCCATTGGCGGTTGGTTA
GGTGATAAAATTCTGGGCACCAAACGCGTTATTATGCTGGGTGCCGTGGTGCTGGCTATCGGTTATGCGCTGGTCGCATG
GTCTGGTCATGACGCTGGCATCGTCTATATGGGCATGGCGGCTATCGCTGTGGGTAACGGTCTGTTTAAAGCTAACCCGT
CTTCCCTGCTGTCTACCTGTTACGCGAAGGACGATCCGCGTCTCGACGGCGCATTTACGATGTATTATATGTCCGTCAAC
ATCGGCTCCTTCTTCTCTATGCTGGCGACGCCGTGGCTGGCGGCGCGTTATGGCTGGAGCACCGCGTTTGCGCTTAGCGT
CGTCGGTATGCTGATAACCGTCGTTAACTTTGCTTTCTGCCAGCGCTGGGTGAAAAGCTACGGTTCCAAACCCGACTTTG
AACCGATCAACTTCCGTAATCTGCTGCTGACCATCGTGGGTATTGTCGTTCTGATTGCGGTCGCCACCTGGCTGCTGCAC
AACCAGGATATCGCACGTATGGTGCTGGGCGTAATCGCTCTTGGCATCGTCATTATCTTCGGTAAAGAAGCGTTTTCCAT
GCACGGCGCGGCTCGCCGTAAAATGATCGTCGCCTTTATTTTGATGCTGCAGGCGATTATCTTCTTCGTACTGTACAGCC
AGATGCCGACGTCGCTGAACTTCTTTGCCATTCGTAACGTCGAGCACTCTATTCTCGGTATCGCGTTCGAACCGGAACAG
TATCAGGCGCTGAACCCATTCTGGATCATTATCGGCAGCCCGATTCTGGCCGCTATCTATAACAGGATGGGCGATACGCT
GCCGATGCCGATGAAATTCGCCATTGGTATGGTGCTGTGTTCCGGCGCGTTCCTGATTCTGCCGCTGGGTGCCAAATTTG
CGAACGATGCCGGCATCGTATCCGTAAACTGGCTGATCGCAAGCTACGGCCTGCAAAGTATCGGTGAGCTGATGATCTCC
GGTCTGGGACTGGCAATGGTCGCACAGTTGGTTCCGCAGCGTCTGATGGGTTTCATCATGGGTAGCTGGTTCCTGACAAC
GGCAGGCGCTAACATCATCGGCGGTTATGTCGCCAACCTGATGGCTGTGCCGAGCGACGTGACTGACCCACTGATGTCCC
TGGAAGTCTATGGTCGCGTATTTATGCAGATTGGCATAGCAACCGCCGTTATCGCCGTCCTGATGCTGCTGACAGCGCCT
AAGCTGAACCGTATGACCCAGGACGATGATACCGCTGAAAAAGGCTCTAAAGCCGCTACAGTTTAA

Upstream 100 bases:

>100_bases
ACCTGCCGTTTCCCCTCCAATATAACAATCGGACGGATGAGTCTGACTCATCACGCGCCAGACAATCCCTGTTAATACGG
GGCGTAAAAAAGAGGTAAAA

Downstream 100 bases:

>100_bases
TTTTCCGGGAAACAACATTCAGGCCGCTAACTGTGCGTTAGCGGCTTTTTTTTTGCTCGTCCCCGCACTACCATACTTTA
AACCTCAGCAAAAAGGAGTT

Product: tripeptide transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSTANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL
GDKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVN
IGSFFSMLATPWLAARYGWSTAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLH
NQDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAFEPEQ
YQALNPFWIIIGSPILAAIYNRMGDTLPMPMKFAIGMVLCSGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAP
KLNRMTQDDDTAEKGSKAATV

Sequences:

>Translated_501_residues
MSTANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL
GDKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVN
IGSFFSMLATPWLAARYGWSTAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLH
NQDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAFEPEQ
YQALNPFWIIIGSPILAAIYNRMGDTLPMPMKFAIGMVLCSGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAP
KLNRMTQDDDTAEKGSKAATV
>Mature_500_residues
STANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLG
DKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVNI
GSFFSMLATPWLAARYGWSTAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLHN
QDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAFEPEQY
QALNPFWIIIGSPILAAIYNRMGDTLPMPMKFAIGMVLCSGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMISG
LGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAPK
LNRMTQDDDTAEKGSKAATV

Specific function: Proton-dependent permease that transports di- and tripeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4827008, Length=387, Percent_Identity=22.7390180878553, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787922, Length=487, Percent_Identity=91.5811088295688, Blast_Score=923, Evalue=0.0,
Organism=Escherichia coli, GI1789911, Length=487, Percent_Identity=50.9240246406571, Blast_Score=512, Evalue=1e-146,
Organism=Escherichia coli, GI1790572, Length=471, Percent_Identity=30.3609341825902, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786927, Length=460, Percent_Identity=28.0434782608696, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17541704, Length=395, Percent_Identity=23.2911392405063, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71987453, Length=368, Percent_Identity=23.3695652173913, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17569141, Length=375, Percent_Identity=24.8, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639585, Length=345, Percent_Identity=26.3768115942029, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639581, Length=354, Percent_Identity=25.4237288135593, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24639583, Length=336, Percent_Identity=26.1904761904762, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571102, Length=367, Percent_Identity=25.3405994550409, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571100, Length=367, Percent_Identity=25.3405994550409, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571098, Length=367, Percent_Identity=25.6130790190736, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 54340; Mature: 54209

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00778 HIS_ACID_PHOSPHAT_2 ; PS50850 MFS ; PS01022 PTR2_1 ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
CCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
TLFSSFSALVYGLVAIGGWLGDKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHH
AIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVNIGSFFSMLATPWLAARYGWS
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHCCCH
TAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NQDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLN
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FFAIRNVEHSILGIAFEPEQYQALNPFWIIIGSPILAAIYNRMGDTLPMPMKFAIGMVLC
EEEEECCCHHHEEEEECCHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHH
SGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM
CCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAP
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLNRMTQDDDTAEKGSKAATV
HHCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
STANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
CCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
TLFSSFSALVYGLVAIGGWLGDKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHH
AIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVNIGSFFSMLATPWLAARYGWS
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHCCCH
TAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NQDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLN
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FFAIRNVEHSILGIAFEPEQYQALNPFWIIIGSPILAAIYNRMGDTLPMPMKFAIGMVLC
EEEEECCCHHHEEEEECCHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHH
SGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM
CCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAP
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLNRMTQDDDTAEKGSKAATV
HHCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]