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The map label for this gene is sppA [H]

Identifier: 16764646

GI number: 16764646

Start: 1372910

End: 1374766

Strand: Reverse

Name: sppA [H]

Synonym: STM1295

Alternate gene names: 16764646

Gene position: 1374766-1372910 (Counterclockwise)

Preceding gene: 16764650

Following gene: 16764645

Centisome position: 28.3

GC content: 55.79

Gene sequence:

>1857_bases
ATGCGAACCCTGTGGCGATTTATTGCCGGATTTTTTAAATGGACGTGGCGAGTGTTGAACTTCGTCCGTGAAATGGTACT
CAACCTGTTCTTTATTTTTCTGGTCCTGGTGGGCGTTGGGATCTGGATGCAGATCGGTAACGGCAGCAACAGTGAGCAAA
CCGCGCGCGGCGCTCTGCTGCTGGATATTTCCGGCGTCATTGTGGATAAACCCTCCACCAATCATCGTCTGGGCGCGCTG
GGTCGCCAGTTATTTGGCGCCAGCTCCGACCGTCTGCAGGAAAACTCCCTGTTTGACATCGTCAACGCTATTCGTCAGGC
GAAAGATGACCGTAATATCACGGGTATCGTTCTGGATCTGAAAAACTTCACCGGCGCCGATCAGCCATCAATGCGCTATA
TCGGTAAAGCGCTGCGCGAATTCCGCGACAGCGGCAAACCGGTTTTCGCCGTGGGTGAAAACTACAGCCAGGGTCAGTAT
TATCTCGCCAGTTTCGCTAATAAAATTTGGCTTTCCCCACAGGGTCAGGTAGATCTTCACGGCTTCGCTACGAATGGCCT
GTACTACAAAACGCTGCTGGATAAACTGAAAGTCTCTACCCACGTTTTCCGGGTCGGCACCTATAAATCCGCCGTCGAGC
CGTTTATCCGCGACGATATGTCGCCCGCCGCCCGCGAGGCCGACAGCCGCTGGATAGGCGAACTGTGGCAGAACTACCTG
CATACCGTTTCCGCCAATCGCCAGATTTCGCCGCAACAACTCTTCCCCGGCGCGCAGGCTATTATCGACGGGTTAACCAG
CGTGGGCGGCGACACCGCCAAATATGCGCTCGACCATAAACTGGTGGACGCCCTCGCCTCCAGCGCAGATGTTGAAAAAG
CGCTGACGAAGCAGTTTGGCTGGAGCAAAACCGAAAATAACTATCGCGCGATCAGCTATTACGATTATTCGCTGAAAACG
CCTGCGGATACCGGCGGTACTATTGCGGTTATTTTCGCCAATGGCGCGATTATGGATGGCGAAGAAACGCCAGGGAATGT
CGGCGGCGACACTACGGCATCGCAGATCCGCGACGCACGCCTTGATCCTAAAGTGAAAGCGATTGTGCTGCGCGTCAATA
GCCCAGGCGGTAGCGTCAACGCCTCCGAAGTTATCCGCGCCGAACTGGCGGCGGCAAGAGCGGCTGGCAAACCGGTGGTG
GTCTCAATGGGCGGTATGGCGGCCTCCGGCGGTTACTGGATCTCTACGCCGGCAAACTATATCGTGGCCAGCCCCAGCAC
GCTGACGGGTTCAATTGGCATCTTCGGCGTCATCAATACGGTAGAAAACAGCCTGTCGTCGATTGGCGTACACAGCGACG
GCGTTTCCACCTCGCCGCTGGCGGATATTTCGATGACCAAAGCGCTGTCACCGGAAGTGCAGCAGATGATGCAACTCAGT
ATTGAGTACGGCTACAAACGCTTTATCACGCTGGTGGCAGACGCGCGTAAGCGTACGCCGGAGCAAATTGATAAAATCGC
ACAAGGCCATGTCTGGACCGGAGAAGACGCGAAAGCCAATGGTCTGGTGGACAGTCTCGGCGACTTTGACGACGCCGTCG
CCAAAGCGGCGGAGCTGGCGAAACTGAAACAGTGGCATCTTGATTACTATCAGGACGAACCGACGGTCCTTGATATGGTC
ATGGACAGTATGACCGGATCAGTACGCGCCATGCTGCCGGAGACCATTCAGGCGATGCTCCCGGCGCCGCTCGTTTCCGC
CGCCAACACGGTGAAGGCCGAGGGGGATAAACTGGCGGCATTTAACGATCCGCAAAACCGTTATGCGTTCTGTTTGACTT
GCGCGAACGTTCGCTAA

Upstream 100 bases:

>100_bases
ATTCCTGCTGACAACTGCCTGATGGGTCATTACGATAGCCACATCTTAATGCTTTATCCTCACCAAGGTACAAGCGTTGT
TACTCAGATAGGGAGAATAC

Downstream 100 bases:

>100_bases
TGCTTCATCAATAGCCATACCGGATGGCGGCGTCTGCTCATAGCCGCCATCCGATAATCATTAATACGTCCTTCGCGACA
CGACTGAACATTATCATGCA

Product: protease 4

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALLLDISGVIVDKPSTNHRLGAL
GRQLFGASSDRLQENSLFDIVNAIRQAKDDRNITGIVLDLKNFTGADQPSMRYIGKALREFRDSGKPVFAVGENYSQGQY
YLASFANKIWLSPQGQVDLHGFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSRWIGELWQNYL
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFGWSKTENNYRAISYYDYSLKT
PADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDARLDPKVKAIVLRVNSPGGSVNASEVIRAELAAARAAGKPVV
VSMGGMAASGGYWISTPANYIVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWHLDYYQDEPTVLDMV
MDSMTGSVRAMLPETIQAMLPAPLVSAANTVKAEGDKLAAFNDPQNRYAFCLTCANVR

Sequences:

>Translated_618_residues
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALLLDISGVIVDKPSTNHRLGAL
GRQLFGASSDRLQENSLFDIVNAIRQAKDDRNITGIVLDLKNFTGADQPSMRYIGKALREFRDSGKPVFAVGENYSQGQY
YLASFANKIWLSPQGQVDLHGFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSRWIGELWQNYL
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFGWSKTENNYRAISYYDYSLKT
PADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDARLDPKVKAIVLRVNSPGGSVNASEVIRAELAAARAAGKPVV
VSMGGMAASGGYWISTPANYIVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWHLDYYQDEPTVLDMV
MDSMTGSVRAMLPETIQAMLPAPLVSAANTVKAEGDKLAAFNDPQNRYAFCLTCANVR
>Mature_618_residues
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALLLDISGVIVDKPSTNHRLGAL
GRQLFGASSDRLQENSLFDIVNAIRQAKDDRNITGIVLDLKNFTGADQPSMRYIGKALREFRDSGKPVFAVGENYSQGQY
YLASFANKIWLSPQGQVDLHGFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSRWIGELWQNYL
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFGWSKTENNYRAISYYDYSLKT
PADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDARLDPKVKAIVLRVNSPGGSVNASEVIRAELAAARAAGKPVV
VSMGGMAASGGYWISTPANYIVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWHLDYYQDEPTVLDMV
MDSMTGSVRAMLPETIQAMLPAPLVSAANTVKAEGDKLAAFNDPQNRYAFCLTCANVR

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=618, Percent_Identity=86.084142394822, Blast_Score=1096, Evalue=0.0,
Organism=Escherichia coli, GI1787527, Length=180, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 67220; Mature: 67220

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCEEE
LDISGVIVDKPSTNHRLGALGRQLFGASSDRLQENSLFDIVNAIRQAKDDRNITGIVLDL
EEECCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
KNFTGADQPSMRYIGKALREFRDSGKPVFAVGENYSQGQYYLASFANKIWLSPQGQVDLH
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHEECCCCCCEEEE
GFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSRWIGELWQNYL
EEEECCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFG
HHHCCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WSKTENNYRAISYYDYSLKTPADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDAR
CCCCCCCEEEEEEEEEEECCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHCC
LDPKVKAIVLRVNSPGGSVNASEVIRAELAAARAAGKPVVVSMGGMAASGGYWISTPANY
CCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCEEEECCCCE
IVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
EEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELA
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEECCCCCCCCCCHHHHCCHHHHHHHHHHHH
KLKQWHLDYYQDEPTVLDMVMDSMTGSVRAMLPETIQAMLPAPLVSAANTVKAEGDKLAA
HHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCHHHHCCCCEEEE
FNDPQNRYAFCLTCANVR
CCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCEEE
LDISGVIVDKPSTNHRLGALGRQLFGASSDRLQENSLFDIVNAIRQAKDDRNITGIVLDL
EEECCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
KNFTGADQPSMRYIGKALREFRDSGKPVFAVGENYSQGQYYLASFANKIWLSPQGQVDLH
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHEECCCCCCEEEE
GFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSRWIGELWQNYL
EEEECCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFG
HHHCCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WSKTENNYRAISYYDYSLKTPADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDAR
CCCCCCCEEEEEEEEEEECCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHCC
LDPKVKAIVLRVNSPGGSVNASEVIRAELAAARAAGKPVVVSMGGMAASGGYWISTPANY
CCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCEEEECCCCE
IVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
EEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELA
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEECCCCCCCCCCHHHHCCHHHHHHHHHHHH
KLKQWHLDYYQDEPTVLDMVMDSMTGSVRAMLPETIQAMLPAPLVSAANTVKAEGDKLAA
HHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCHHHHCCCCEEEE
FNDPQNRYAFCLTCANVR
CCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]