BacMap

Definition	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome.
Accession	NC_003197
Length	4,857,432

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The map label for this gene is hpaE [H]

Identifier: 16764460

GI number: 16764460

Start: 1189507

End: 1190973

Strand: Direct

Name: hpaE [H]

Synonym: STM1102

Alternate gene names: 16764460

Gene position: 1189507-1190973 (Clockwise)

Preceding gene: 16764459

Following gene: 16764461

Centisome position: 24.49

GC content: 59.71

Gene sequence:

>1467_bases
ATGAAGAAAATAAATCATTGGATTAACGGCAAAAATGTTGCAGGTAACGACTACTTCCAGACCACTAACCCGGCGACCGG
TGACGTGCTGGCGGAAGTGGCCTCCGGCGGTGAAGCAGAGGTGAACCAAGCTGTCGCGGCGGCAAAAGAGGCGTTCCCGA
AATGGGCCAACCTGCCGATGAAAGAGCGCGCGCGCCTGATGCGCCGCCTTGGCGACCTGATTGACCAGCATGTGCCGGAA
ATCGCGGCGATGGAAACCGCCGACACCGGCCTGCCTATTCACCAGACTAAAAACGTGCTGATCCCGCGCGCCTCGCATAA
CTTCGAATTCTTCGCCGAAGTGTGCCAGCAGATGAACGGCAAGACCTATCCTGTTGACGATAAAATGCTCAATTATACGC
TGGTGCAGCCCGTCGGCGTCTGCGCGCTGGTGTCGCCGTGGAACGTGCCGTTTATGACCGCGACCTGGAAAGTCGCGCCG
TGCCTGGCGCTGGGCAACACCGCGGTGCTCAAAATGTCCGAGCTGTCGCCGCTGACTGCCGACAGGCTGGGCGAGCTGGC
GCTGGAGGCAGGAATTCCGGCAGGCGTGCTGAACGTGGTGCAGGGCTATGGCGCGACGGCGGGCGATGCGCTGGTACGCC
ACCATGACGTGCGTGCGGTGTCGTTTACCGGCGGTACCGCCACCGGTCGCAATATCATGAAAAATGCCGGGCTGAAAAAA
TACTCGATGGAGCTGGGCGGCAAATCGCCGGTGCTGATTTTTGAAGATGCCGACATTGAGCGCGCGCTGGACGCCGCGCT
GTTCACCATCTTCTCGATCAACGGCGAACGCTGCACCGCCGGGTCGCGCATCTTTATCCAGCAGAGCATTTACCCTGAGT
TCGTGAAGCGCTTTGCCGAACGCGCGAATCGCCTGCGTGTCGGCGATCCGACCGACCCGAACACCCAGGTCGGCGCGCTG
ATTAGCCAACAGCACTGGGAAAAAGTCTCCGGTTATATTCGCCTCGGCATTGAAGAGGGCGCAACGCTGCTGGCGGGCGG
TGCGGAAAAACCCACTGACCTGCCTGCGCATCTGAAAGGCGGTAACTTCCTGCGCCCAACCGTGCTGGCCGATGTCGACA
ACCGTATGCGCGTCGCGCAGGAAGAGATCTTTGGGCCAGTCGCCTGTCTGCTGCCATTCAAAGACGAAGCGGAAGGGTTA
CGTTTGGCGAACGACGTGGAATACGGTCTGGCCTCTTATATCTGGACCCAGGACGTGAGCAAAGTGTTGCGCCTGGCGCG
TGGGATTGAAGCCGGCATGGTCTTCGTCAACACCCAGAACGTCCGCGACCTGCGCCAGCCGTTCGGCGGCGTGAAAGCCT
CCGGTACCGGGCGCGAAGGCGGCGAATATAGCTTCGAAGTGTTTGCGGAAATGAAAAACGTCTGCATCTCAATGGGCGAC
CATCCTATCCCAAAATGGGGAGTTTGA

Upstream 100 bases:

>100_bases
CGAAAGGGCTGTCCGATGTGGTGCCGGGGGATGAAGTTGTCGTGGAAGTAGAAGGCGTGGGCCGCCTGGTTAACCGAATC
GTCAGTGAGGAGAGCGCAAA

Downstream 100 bases:

>100_bases
TATGGGCAAGTTAGCGTTAGCAGCAAAAATTACCCACGTGCCGTCGATGTATCTTTCTGAACTGCCGGGAAAAAATCACG
GTTGTCGTCAGGCAGCCATT

Product: 4-hydroxyphenylacetate catabolism

Products: 5-carboxymethyl-2-hydroxymuconate; NADH; H+

Alternate protein names: CHMS dehydrogenase [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MKKINHWINGKNVAGNDYFQTTNPATGDVLAEVASGGEAEVNQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQHVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPTDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGAEKPTDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV

Sequences:

>Translated_488_residues
MKKINHWINGKNVAGNDYFQTTNPATGDVLAEVASGGEAEVNQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQHVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPTDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGAEKPTDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV
>Mature_488_residues
MKKINHWINGKNVAGNDYFQTTNPATGDVLAEVASGGEAEVNQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQHVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPTDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGAEKPTDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV

Specific function: Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM) [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI12007648, Length=476, Percent_Identity=40.9663865546218, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI25777730, Length=480, Percent_Identity=41.4583333333333, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI25777732, Length=480, Percent_Identity=41.25, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI153266822, Length=482, Percent_Identity=39.6265560165975, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI25777724, Length=480, Percent_Identity=39.5833333333333, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI238814322, Length=485, Percent_Identity=39.5876288659794, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI115387104, Length=459, Percent_Identity=40.0871459694989, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI21614513, Length=466, Percent_Identity=40.5579399141631, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI21361176, Length=480, Percent_Identity=38.5416666666667, Blast_Score=344, Evalue=9e-95,
Organism=Homo sapiens, GI25777728, Length=420, Percent_Identity=40.7142857142857, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI25952152, Length=476, Percent_Identity=35.0840336134454, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI25777726, Length=477, Percent_Identity=36.2683438155136, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI301500698, Length=481, Percent_Identity=34.7193347193347, Blast_Score=291, Evalue=9e-79,
Organism=Homo sapiens, GI4507229, Length=483, Percent_Identity=35.6107660455487, Blast_Score=273, Evalue=4e-73,
Organism=Homo sapiens, GI25777721, Length=496, Percent_Identity=34.4758064516129, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI188035924, Length=495, Percent_Identity=26.8686868686869, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI310128093, Length=477, Percent_Identity=27.4633123689727, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI310128103, Length=477, Percent_Identity=27.2536687631027, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI11095441, Length=485, Percent_Identity=29.2783505154639, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI310128091, Length=470, Percent_Identity=27.2340425531915, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI223972651, Length=464, Percent_Identity=27.801724137931, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI310128089, Length=339, Percent_Identity=30.9734513274336, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI238859541, Length=466, Percent_Identity=26.1802575107296, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI25777736, Length=466, Percent_Identity=26.1802575107296, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI25777734, Length=466, Percent_Identity=26.1802575107296, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI310128097, Length=263, Percent_Identity=32.6996197718631, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI310128095, Length=318, Percent_Identity=29.874213836478, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557303, Length=345, Percent_Identity=28.9855072463768, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI73466520, Length=345, Percent_Identity=28.9855072463768, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI206597441, Length=452, Percent_Identity=26.3274336283186, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI206597439, Length=452, Percent_Identity=26.3274336283186, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI22907049, Length=452, Percent_Identity=26.3274336283186, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI223972653, Length=462, Percent_Identity=24.8917748917749, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI73695881, Length=347, Percent_Identity=25.9365994236311, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI73695879, Length=347, Percent_Identity=25.9365994236311, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4502043, Length=342, Percent_Identity=26.9005847953216, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI238814371, Length=342, Percent_Identity=26.9005847953216, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI71773324, Length=342, Percent_Identity=26.9005847953216, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI310128087, Length=294, Percent_Identity=23.469387755102, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI310128101, Length=236, Percent_Identity=21.6101694915254, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI310128099, Length=236, Percent_Identity=21.6101694915254, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787558, Length=480, Percent_Identity=39.375, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI1789015, Length=478, Percent_Identity=38.4937238493724, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1786504, Length=463, Percent_Identity=39.3088552915767, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI87082295, Length=492, Percent_Identity=38.2113821138211, Blast_Score=331, Evalue=6e-92,
Organism=Escherichia coli, GI87081896, Length=464, Percent_Identity=37.9310344827586, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1787715, Length=476, Percent_Identity=38.0252100840336, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1787684, Length=476, Percent_Identity=31.3025210084034, Blast_Score=245, Evalue=6e-66,
Organism=Escherichia coli, GI87081926, Length=461, Percent_Identity=29.9349240780911, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788042, Length=474, Percent_Identity=29.535864978903, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1787250, Length=466, Percent_Identity=26.8240343347639, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1787653, Length=301, Percent_Identity=26.2458471760797, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25144435, Length=466, Percent_Identity=41.4163090128755, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562198, Length=480, Percent_Identity=40.2083333333333, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133930964, Length=485, Percent_Identity=38.5567010309278, Blast_Score=347, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI25143876, Length=486, Percent_Identity=37.4485596707819, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI25143874, Length=486, Percent_Identity=37.4485596707819, Blast_Score=334, Evalue=6e-92,
Organism=Caenorhabditis elegans, GI32564736, Length=420, Percent_Identity=40.9523809523809, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17551164, Length=481, Percent_Identity=38.2536382536383, Blast_Score=328, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI71995606, Length=485, Percent_Identity=34.2268041237113, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71995613, Length=421, Percent_Identity=34.4418052256532, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17534119, Length=473, Percent_Identity=32.1353065539112, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI71986308, Length=442, Percent_Identity=31.447963800905, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI115534176, Length=488, Percent_Identity=26.0245901639344, Blast_Score=175, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI25146391, Length=342, Percent_Identity=31.8713450292398, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32566756, Length=342, Percent_Identity=31.8713450292398, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25146394, Length=342, Percent_Identity=31.8713450292398, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17534447, Length=483, Percent_Identity=26.2939958592132, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17564084, Length=357, Percent_Identity=30.812324929972, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32564151, Length=443, Percent_Identity=26.1851015801354, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI115532534, Length=341, Percent_Identity=27.2727272727273, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71990744, Length=323, Percent_Identity=25.077399380805, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320917, Length=484, Percent_Identity=38.6363636363636, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6324950, Length=474, Percent_Identity=38.1856540084388, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6325196, Length=481, Percent_Identity=38.045738045738, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323822, Length=468, Percent_Identity=37.1794871794872, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6323821, Length=468, Percent_Identity=36.1111111111111, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6319478, Length=482, Percent_Identity=35.2697095435685, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6321828, Length=503, Percent_Identity=26.6401590457256, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321826, Length=504, Percent_Identity=25.9920634920635, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323757, Length=359, Percent_Identity=27.0194986072423, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI20129399, Length=480, Percent_Identity=43.3333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24585660, Length=482, Percent_Identity=37.7593360995851, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI281362580, Length=476, Percent_Identity=36.7647058823529, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI62472918, Length=476, Percent_Identity=36.7647058823529, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI62472926, Length=476, Percent_Identity=36.7647058823529, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI62472936, Length=476, Percent_Identity=36.7647058823529, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI21356737, Length=476, Percent_Identity=36.7647058823529, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24650465, Length=471, Percent_Identity=39.7027600849257, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24666674, Length=474, Percent_Identity=26.7932489451477, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24638878, Length=439, Percent_Identity=31.4350797266515, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24638876, Length=439, Percent_Identity=31.4350797266515, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24668425, Length=454, Percent_Identity=25.7709251101322, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24668417, Length=454, Percent_Identity=25.7709251101322, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24668413, Length=454, Percent_Identity=25.7709251101322, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281360301, Length=355, Percent_Identity=26.1971830985915, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI281360299, Length=355, Percent_Identity=26.1971830985915, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI281360297, Length=355, Percent_Identity=26.1971830985915, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI281360295, Length=355, Percent_Identity=26.1971830985915, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24586250, Length=355, Percent_Identity=26.1971830985915, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI45552499, Length=356, Percent_Identity=25.561797752809, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360303, Length=356, Percent_Identity=25.561797752809, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28571806, Length=492, Percent_Identity=22.3577235772358, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571798, Length=492, Percent_Identity=22.3577235772358, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571796, Length=492, Percent_Identity=22.3577235772358, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571794, Length=492, Percent_Identity=22.3577235772358, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571802, Length=492, Percent_Identity=22.3577235772358, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28571800, Length=492, Percent_Identity=22.3577235772358, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28574525, Length=466, Percent_Identity=22.3175965665236, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR011985 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: 1.2.1.60

Molecular weight: Translated: 53040; Mature: 53040

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKINHWINGKNVAGNDYFQTTNPATGDVLAEVASGGEAEVNQAVAAAKEAFPKWANLPM
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHCCCCH
KERARLMRRLGDLIDQHVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNG
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSELSPLTA
CCCCCCCHHHCEEEECCCCEEEEECCCCCCEEEECCCHHHHHEECCCEEEEECCCCCCCH
DRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCCE
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAE
EHHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCEEEEEHHHHHHHHHHHHH
RANRLRVGDPTDPNTQVGALISQQHWEKVSGYIRLGIEEGATLLAGGAEKPTDLPAHLKG
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCCCCCCCCCC
GNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGLRLANDVEYGLASYIWTQDVS
CCEECCHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHH
KVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
HPIPKWGV
CCCCCCCC
>Mature Secondary Structure
MKKINHWINGKNVAGNDYFQTTNPATGDVLAEVASGGEAEVNQAVAAAKEAFPKWANLPM
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHCCCCH
KERARLMRRLGDLIDQHVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNG
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSELSPLTA
CCCCCCCHHHCEEEECCCCEEEEECCCCCCEEEECCCHHHHHEECCCEEEEECCCCCCCH
DRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCCE
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAE
EHHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCEEEEEHHHHHHHHHHHHH
RANRLRVGDPTDPNTQVGALISQQHWEKVSGYIRLGIEEGATLLAGGAEKPTDLPAHLKG
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCCCCCCCCCC
GNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGLRLANDVEYGLASYIWTQDVS
CCEECCHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHH
KVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
HPIPKWGV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-carboxymethyl-2-hydroxymuconate semialdehyde; H2O; NAD+

Specific reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737515 [H]