Click here to switch to the map view.

The map label for this gene is dmsA [H]

Identifier: 16764325

GI number: 16764325

Start: 1045321

End: 1047765

Strand: Direct

Name: dmsA [H]

Synonym: STM0964

Alternate gene names: 16764325

Gene position: 1045321-1047765 (Clockwise)

Preceding gene: 16764324

Following gene: 16764326

Centisome position: 21.52

GC content: 53.54

Gene sequence:

>2445_bases
ATGAAAACTAAGATCCCTGATGCCGTGCTGGCAGCCGAGGTGAGCCGTCGTGGTTTAGTCAAAACCACCGCGATAGGCGG
CCTGGCGATGGCCAGTAGCGCATTTACCCTGCCATTTACCCGCATCGCTAACGCCGCAGAGGCAATAAGCCCGGCGAAAA
CCGGCGAGAAAGTCGTCTGGAGCGCCTGTACGGTAAACTGTGGCAGCCGTTGTCCGCTACGTATGCATGTTGTGGATGGC
GAAATCAAATATGTAGAAACGGATAATACCGGAAACGATGATTACGATGGCCTGCACCAGGTTCGCGCCTGCCTGCGCGG
TCGTTCTATGCGCCGTCGCGTCTATAACCCGGATCGGCTCAAGTATCCGATGAAGCGCGTCGGCGCGCGCGGCGAAGGTA
AATTTGAGCGTATTAGCTGGGACGAAGCCTACGATATCATTGCCACCAATATGCAGCGTCTTATCAAAGAGTATGGCAAC
GAGTCCATTTATCTGAACTATGGCACGGGAACGCTGGGCGGCACTTTGACACGTTCATGGCCGCCAGGAAAAACGCTGGT
CGCTCGTCTGATGAACTGCTGCGGCGGTTATCTTAATCACTACGGTGATTACTCTTCCGCGCAAATCGCAGCGGGTCTGA
ACTACACCTATGGCGGCTGGGCGGATGGCAATAGTCCGTCCGACATTGAAAACAGTAAGCTGGTGGTATTGTTTGGCAAT
AACCCTGGCGAAACCCGCATGAGCGGGGGCGGTGTAACGTATTATCTTGAACAGGCGCGGCAGAAATCAAACGCGCGGAT
GATCATTATCGACCCTCGTTACACCGACACTGGCGCTGGTCGCGAAGATGAGTGGATTCCGATTCGTCCAGGTACCGATG
CGGCGCTGGTCAATGGTCTGGCATATGTCTTAATCACCGAGAACATGGTCGATCAGCCGTTCCTGGATAAATATTGCGTT
GGTTATGACGAAAAAACCTTGCCTGCCAGCGCGCCGAAAAACGGTCACTACAAAGCCTATATTCTGGGCCAGGGTAAAGA
CGGTATCGCGAAGACGCCGGAGTGGGCGGCGCAAATTACCGGTATCCCGGCGGATCGCATTATTAAGCTGGCGCGAGAAA
TCGGCAGCGCTAAACCCGCCTATATTTGCCAGGGATGGGGACCACAACGTCATGCTAATGGAGAAATCGCCACGCGCGCC
ATCTCGATGCTGGCGATCCTGACGGGTAATGTTGGGATTAACGGAGGTAATAGCGGCGCGCGCGAAGGGTCTTATGCCCT
GCCATTTGAACGTATGCCCACGTTAGAAAACCCGGTTGAAACCAGCATCTCCATGTTTATGTGGACCGATGCCATTGAAC
GCGGCCCGGAAATGACGGCGCTGCGTGATGGCGTGCGGGGGAAAGATAAGCTGGACGTGCCGATCAAAATGATCTGGAAC
TATGCTGGCAACTGTTTGATTAACCAGCACTCTGAGATTAACCGCACCCACGAAATCCTGCAGGATGACAAGAAATGCGA
AATGATCGTCGTTATCGACTGTCATATGACCTCGTCGGCAAAATACGCCGATATTCTGTTGCCTGATTGCACTGCTTCTG
AGCAGATGGACTTTGCGCTGGATGCCTCCTGCGGGAACATGTCTTACGTTATCTTCACTGACCAGGCGATTAAACCGCGC
TTCGAGTGTAAGACGATTTATGAGATGACCAGCGAACTGGCGAAACGTCTTGGCGTGGAACAACAGTTTACCGAAGGACG
GACGCAAGAAGAGTGGATGCGTCATCTGTACGAACAGTCGCGTAAATCCATTCCGAATCTGCCCACCTTTGAGGAGTTCC
GTAAGCAAGGCATCTTCAAACAGCGTGACCCCGAAGGCCACCATGTCGCCTATAAAGACTTCCGCGAAGATCCGCAAGCG
AATCCACTTACAACGCCATCGGGCAAGATTGAAATCTATTCACAGGCGTTGGCGGATATCGCCGCCACCTGGGAGCTGCC
GGAAGGCGACGTGATCGATCCATTACCGATCTACACGCCAGGTTTTGAAAACTATAACGATCCGCTAACGGATAAATTCC
CGCTGCAGTTGACGGGTTTCCACTATAAAGCGCGTGTACATTCCACTTATGGCAACGTAGACGTACTGAAAGCCGCCTGT
CGCCAGGAAATGTGGATTAACCCAATGGATGCGCAGAAACGCGGTATCAACAATGGCGACAAAGTCCGCATCTTCAACGA
TCGCGGCGAAGTACATATCGAGGCTAAAGTGACGCCGCGCATGATGCCGGGCGTGGTCGCCCTGGGAGAAGGCGCATGGT
ATGACCCGGATGCAAAACGCGTGGATCAGGGCGGATGTATTAACGTACTGACGACCCAACGTCCTTCTCCGCTGGCGAAG
GGGAACCCGTCACATACGAACCTCGTTCAGGTTGAAAAGGCGTAA

Upstream 100 bases:

>100_bases
TTTTTCGATATATATCAGACTTTATAGCGATGCTATCGCTATATAAAATTCTATACATCGTTTTATTGTTTTTTTATTGT
GAGCAGCAGAGTGAGCCCTT

Downstream 100 bases:

>100_bases
GGAGTAACCGATGACAACCCAGTATGGATTTTTTATTGATTCCAGCCGTTGCACCGGTTGCAAAACCTGCGAACTGGCCT
GCAAGGACTACAAAGATTTG

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 814; Mature: 814

Protein sequence:

>814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPAKTGEKVVWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGN
ESIYLNYGTGTLGGTLTRSWPPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVLITENMVDQPFLDKYCV
GYDEKTLPASAPKNGHYKAYILGQGKDGIAKTPEWAAQITGIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFTDQAIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQSRKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDQGGCINVLTTQRPSPLAK
GNPSHTNLVQVEKA

Sequences:

>Translated_814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPAKTGEKVVWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGN
ESIYLNYGTGTLGGTLTRSWPPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVLITENMVDQPFLDKYCV
GYDEKTLPASAPKNGHYKAYILGQGKDGIAKTPEWAAQITGIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFTDQAIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQSRKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDQGGCINVLTTQRPSPLAK
GNPSHTNLVQVEKA
>Mature_814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPAKTGEKVVWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGN
ESIYLNYGTGTLGGTLTRSWPPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVLITENMVDQPFLDKYCV
GYDEKTLPASAPKNGHYKAYILGQGKDGIAKTPEWAAQITGIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFTDQAIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQSRKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDQGGCINVLTTQRPSPLAK
GNPSHTNLVQVEKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=814, Percent_Identity=93.2432432432432, Blast_Score=1589, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=804, Percent_Identity=68.6567164179104, Blast_Score=1171, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=817, Percent_Identity=66.8298653610771, Blast_Score=1144, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=759, Percent_Identity=32.0158102766798, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=31.6688567674113, Blast_Score=301, Evalue=1e-82,
Organism=Escherichia coli, GI87081994, Length=752, Percent_Identity=31.781914893617, Blast_Score=287, Evalue=2e-78,
Organism=Escherichia coli, GI3868721, Length=782, Percent_Identity=25.0639386189258, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI3868720, Length=468, Percent_Identity=26.0683760683761, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1788534, Length=839, Percent_Identity=22.8843861740167, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI3868719, Length=462, Percent_Identity=25.3246753246753, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1787477, Length=348, Percent_Identity=25.2873563218391, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1787741, Length=309, Percent_Identity=25.2427184466019, Blast_Score=83, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 90348; Mature: 90348

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPAKTGEKVVW
CCCCCCHHHHHHHHHHCCCEEEHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEE
SACTVNCGSRCPLRMHVVDGEIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRL
EEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHH
KYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTLTRSW
CCCHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
PPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGL
CCCCCEECCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHCCE
AYVLITENMVDQPFLDKYCVGYDEKTLPASAPKNGHYKAYILGQGKDGIAKTPEWAAQIT
EEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHCC
GIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGA
CCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
REGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHC
YAGNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFAL
CCCCEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCEEE
DASCGNMSYVIFTDQAIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQS
ECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHH
RKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQANPLTTPSGKIEIYSQALADI
HHCCCCCCCHHHHHHCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCEEEHHHHHHHH
AATWELPEGDVIDPLPIYTPGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECEEEEEEEECCCCCHHHHHHHH
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKR
HHHHCCCCCCHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCHHH
VDQGGCINVLTTQRPSPLAKGNPSHTNLVQVEKA
CCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSAFTLPFTRIANAAEAISPAKTGEKVVW
CCCCCCHHHHHHHHHHCCCEEEHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEE
SACTVNCGSRCPLRMHVVDGEIKYVETDNTGNDDYDGLHQVRACLRGRSMRRRVYNPDRL
EEEEECCCCCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHH
KYPMKRVGARGEGKFERISWDEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTLTRSW
CCCHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
PPGKTLVARLMNCCGGYLNHYGDYSSAQIAAGLNYTYGGWADGNSPSDIENSKLVVLFGN
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGL
CCCCCEECCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHCCE
AYVLITENMVDQPFLDKYCVGYDEKTLPASAPKNGHYKAYILGQGKDGIAKTPEWAAQIT
EEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHCC
GIPADRIIKLAREIGSAKPAYICQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGA
CCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
REGSYALPFERMPTLENPVETSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHC
YAGNCLINQHSEINRTHEILQDDKKCEMIVVIDCHMTSSAKYADILLPDCTASEQMDFAL
CCCCEEEECCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCEEE
DASCGNMSYVIFTDQAIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYEQS
ECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHH
RKSIPNLPTFEEFRKQGIFKQRDPEGHHVAYKDFREDPQANPLTTPSGKIEIYSQALADI
HHCCCCCCCHHHHHHCCCCCCCCCCCCEEEHHHHHCCCCCCCCCCCCCCEEEHHHHHHHH
AATWELPEGDVIDPLPIYTPGFENYNDPLTDKFPLQLTGFHYKARVHSTYGNVDVLKAAC
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECEEEEEEEECCCCCHHHHHHHH
RQEMWINPMDAQKRGINNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKR
HHHHCCCCCCHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCHHH
VDQGGCINVLTTQRPSPLAKGNPSHTNLVQVEKA
CCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]