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The map label for this gene is deoR [H]

Identifier: 16764226

GI number: 16764226

Start: 936744

End: 937502

Strand: Reverse

Name: deoR [H]

Synonym: STM0864

Alternate gene names: 16764226

Gene position: 937502-936744 (Counterclockwise)

Preceding gene: 16764227

Following gene: 16764224

Centisome position: 19.3

GC content: 51.91

Gene sequence:

>759_bases
ATGGAAACGCGACGCGACGAGCGTATTGGTCAATTGCTGCAGGCCTTAAAACGCAGCGATAAACTTCATCTTAAAGAAGC
CGCGACCCTGTTGGGCGTCTCTGAAATGACCATTCGTCGCGACCTGAACCATAAAAGCGCGCCTGTCGTGTTGCTAGGCG
GCTATATCGTACTGGAGCCCCGCAGCGCCAGTCATTATCTGTTAAGCGATCAAAAATCTCGTCTGGTGGAAGAAAAACGC
CGAGCCGCTCAGCTGGCTGCGGGCCTGGTACAAGCGCATCAGACGGTATTTATTGACTGCGGCACCACCACGCCGTGGAT
CATTGAAGCCATTGATAATGACCTTCCCTTTACGGCGGTGTGCTATTCACTTAATACCTTCCTGGCGCTGCAGGACAAAC
CCCATTGCCGCGCCATCCTCAGCGGCGGGGAGTTTCACGCCAGCAACGCCATTTTCAAACCGCTTGATTTCCATGAAACG
TTAAACAATATTTGTCCGGATATCGCGTTTTATTCCGCCGCTGGCGTTCATACCAGTAAAGGCGCTACCTGCTTTAATCT
GGAAGAGCTGCCGGTAAAACATTGGGCAATGACAATGGCACAGTGCCATGTACTGGTGGTGGATCACAGTAAATTCGGCA
AGGTACGTCCGGCGCGGATGGGGGAATTATCACGCTTTGATACGATTATCAGCGACCGCCGTCCCGATGAGGCCTTTGTG
GCCTACGCTAAAGCGCAACAAATTACTCTGATGTATTAA

Upstream 100 bases:

>100_bases
CCATTCGAAAAGGCTGGGTACGTGACTAAATAGCGAAAAAAAGAGTAATATTAAGCGCTCTGTATGGTGCGGAGCGCTTA
TTTAACTCTCCAGGGGAACT

Downstream 100 bases:

>100_bases
CCGCCCGTAGCCGGATGCGACGCGCACCCGGCTACGGAGTTATTTTACGAGAACCAACTGCCAAACCACTGATGGAGTTT
CATCAGCACAAAATCCCACA

Product: DNA-binding transcriptional repressor DeoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
METRRDERIGQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNHKSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAQLAAGLVQAHQTVFIDCGTTTPWIIEAIDNDLPFTAVCYSLNTFLALQDKPHCRAILSGGEFHASNAIFKPLDFHET
LNNICPDIAFYSAAGVHTSKGATCFNLEELPVKHWAMTMAQCHVLVVDHSKFGKVRPARMGELSRFDTIISDRRPDEAFV
AYAKAQQITLMY

Sequences:

>Translated_252_residues
METRRDERIGQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNHKSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAQLAAGLVQAHQTVFIDCGTTTPWIIEAIDNDLPFTAVCYSLNTFLALQDKPHCRAILSGGEFHASNAIFKPLDFHET
LNNICPDIAFYSAAGVHTSKGATCFNLEELPVKHWAMTMAQCHVLVVDHSKFGKVRPARMGELSRFDTIISDRRPDEAFV
AYAKAQQITLMY
>Mature_252_residues
METRRDERIGQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNHKSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKR
RAAQLAAGLVQAHQTVFIDCGTTTPWIIEAIDNDLPFTAVCYSLNTFLALQDKPHCRAILSGGEFHASNAIFKPLDFHET
LNNICPDIAFYSAAGVHTSKGATCFNLEELPVKHWAMTMAQCHVLVVDHSKFGKVRPARMGELSRFDTIISDRRPDEAFV
AYAKAQQITLMY

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=252, Percent_Identity=83.3333333333333, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1789829, Length=238, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789519, Length=230, Percent_Identity=25.6521739130435, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787540, Length=241, Percent_Identity=27.3858921161826, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790753, Length=243, Percent_Identity=26.7489711934156, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI226510968, Length=249, Percent_Identity=29.3172690763052, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788069, Length=249, Percent_Identity=22.8915662650602, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789059, Length=241, Percent_Identity=24.4813278008299, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI87082344, Length=247, Percent_Identity=22.6720647773279, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28205; Mature: 28205

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRRDERIGQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNHKSAPVVLLGGYIVLEP
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECC
RSASHYLLSDQKSRLVEEKRRAAQLAAGLVQAHQTVFIDCGTTTPWIIEAIDNDLPFTAV
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHEECCCCCCHHHH
CYSLNTFLALQDKPHCRAILSGGEFHASNAIFKPLDFHETLNNICPDIAFYSAAGVHTSK
HHHHHHEEEECCCCCCCEEECCCCEECCCCCCCCCCHHHHHHHHCCHHHHHHCCCCCCCC
GATCFNLEELPVKHWAMTMAQCHVLVVDHSKFGKVRPARMGELSRFDTIISDRRPDEAFV
CCEEECHHHCCHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
AYAKAQQITLMY
EEHHHCEEEEEC
>Mature Secondary Structure
METRRDERIGQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNHKSAPVVLLGGYIVLEP
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECC
RSASHYLLSDQKSRLVEEKRRAAQLAAGLVQAHQTVFIDCGTTTPWIIEAIDNDLPFTAV
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHEECCCCCCHHHH
CYSLNTFLALQDKPHCRAILSGGEFHASNAIFKPLDFHETLNNICPDIAFYSAAGVHTSK
HHHHHHEEEECCCCCCCEEECCCCEECCCCCCCCCCHHHHHHHHCCHHHHHHCCCCCCCC
GATCFNLEELPVKHWAMTMAQCHVLVVDHSKFGKVRPARMGELSRFDTIISDRRPDEAFV
CCEEECHHHCCHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
AYAKAQQITLMY
EEHHHCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]