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The map label for this gene is dxs [H]

Identifier: 16763802

GI number: 16763802

Start: 474630

End: 476492

Strand: Reverse

Name: dxs [H]

Synonym: STM0422

Alternate gene names: 16763802

Gene position: 476492-474630 (Counterclockwise)

Preceding gene: 16763803

Following gene: 16763801

Centisome position: 9.81

GC content: 55.56

Gene sequence:

>1863_bases
ATGAGTTTTGATATAGCCAAATACCCTACCCTGGCATTGGTCGACTCCACCCAGGAGTTACGACTGTTACCGAAAGAGAG
TCTGCCGAAACTCTGCGACGAGCTACGCCGCTACTTACTCGACAGCGTAAGCCGTTCCAGCGGGCATTTCGCTTCCGGGC
TGGGCACGGTAGAACTTACCGTGGCGCTGCATTATGTCTACAACACCCCGTTTGACCAGCTAATCTGGGATGTTGGACAC
CAGGCTTATCCACATAAAATCCTTACCGGTCGTCGCGACAAAATCGGCACCATTCGCCAGAAAGGCGGTCTGCACCCGTT
CCCGTGGCGCGGAGAAAGCGAATACGATGTGCTGAGCGTTGGGCATTCCTCCACCTCCATCAGCGCCGGTATCGGTATTG
CCGTGGCGGCGGAGAAAGAAGGCAAAGATCGCCGCACCGTCTGTGTGATTGGCGACGGCGCCATCACCGCCGGTATGGCG
TTTGAAGCAATGAATCACGCAGGCGATATCCGGCCCGACATGCTGGTCATTCTGAACGACAATGAAATGTCGATTTCGGA
AAACGTCGGCGCGCTCAACAACCATCTGGCGCAGCTACTTTCCGGTAAGCTTTACTCTTCTCTGCGCGAAGGCGGAAAAA
AGGTCTTCTCCGGCGTACCGCCAATTAAAGAACTGCTCAAGCGTACCGAAGAACATATTAAAGGCATGGTTGTGCCGGGC
ACACTGTTCGAAGAGCTGGGCTTTAACTACATCGGGCCGGTCGATGGTCACGATGTCATGGGGCTTATCAGCACATTGAA
GAACATGCGCGACCTGAAAGGGCCGCAGTTCCTGCATATCATGACCAAGAAAGGCCGCGGCTATGAGCCCGCGGAAAAAG
ATCCGATCACTTTCCATGCGGTGCCTAAATTTGATCCCTCCAGCGGATGTTTGCCGAAAAGCAGCGGCGGTCTGCCCGGT
TATTCAAAAATCTTCGGTGACTGGCTGTGTGAAACCGCCGCCAAAGACAGCAAGCTGATGGCGATCACCCCGGCAATGCG
CGAAGGTTCCGGCATGGTGGAATTTTCACGTAAATTCCCGGATCGCTATTTTGACGTCGCCATCGCCGAGCAGCATGCCG
TCACCTTCGCCGCAGGTCTGGCGATTGGCGGCTATAAGCCCGTCGTGGCGATCTACTCTACTTTCCTGCAACGCGCCTAC
GATCAGGTCATCCATGACGTCGCTATCCAGAAACTGCCGGTCATGTTCGCCATCGATCGCGCCGGTATCGTTGGCGCGGA
TGGACAAACACACCAGGGCGCGTTCGATCTCTCCTATCTGCGCTGCATCCCGGATATGGTGATCATGACGCCAAGCGACG
AAAACGAATGTCGCCAGATGTTATTTACCGGGTATCACTATAACGACGGCCCGACGGCAGTACGTTATCCACGCGGTAAT
GCGCAGGGCGTGGCGCTAACCCCGCTGGAAAAACTGCCTATTGGTAAAGGCCTTGTGAAGCGTCATGGCGAAAAACTGGC
GATTCTGAACTTTGGCACCTTAATGCCTGAGGCGGCGAAAGTCGCCGAAGCGCTGAACGCCACGCTGGTCGACATGCGCT
TTGTTAAGCCGCTGGACGACACGTTAATTCTGGAGATGGCCGCGCAGCATGACGCGCTGGTGACGCTGGAAGAAAACGCC
ATTATGGGCGGCGCTGGCAGCGGCGTAAACGAAGTGCTAATGGCCCATCGTAAACCTGTACCTGTGCTGAATATCGGTCT
TCCGGATTTCTTTATCCCGCAAGGAACGCAGGAAGAAGCCCGCGCGGAACTGGGGCTTGACGCCGCAGGCATTGAAGCCA
AAATCAAGGCCTGGCTGGCATAA

Upstream 100 bases:

>100_bases
ATCAGCTGGCCGCGCAATCACTGGACACCTCGGCACTGGAAGCGCTAGCGAACTACATAATCCAGCGTGATAAATAAACC
CCATATCCAATGAGCTTGCG

Downstream 100 bases:

>100_bases
TCCCCTCTTTGCTCCTGCTATGCTTGAAGAGTGACGGGTATAACAGGAGCGGAGTCATGCAATACAACACGTTAGGAAAT
ACAGATCTTCGGGTATCCCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPG
YSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN
AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA

Sequences:

>Translated_620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPG
YSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN
AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA
>Mature_619_residues
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQ
AYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAF
EAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGT
LFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPGY
SKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYD
QVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGNA
QGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAI
MGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=499, Percent_Identity=23.6472945891784, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4507521, Length=499, Percent_Identity=23.6472945891784, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=23.5412474849095, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637463, Length=540, Percent_Identity=23.5185185185185, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI225637461, Length=540, Percent_Identity=23.5185185185185, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI225637459, Length=540, Percent_Identity=23.5185185185185, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=96.2903225806452, Blast_Score=1241, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=504, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24645119, Length=529, Percent_Identity=24.5746691871456, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551847, Length=529, Percent_Identity=24.7637051039698, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550715, Length=529, Percent_Identity=24.7637051039698, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666278, Length=488, Percent_Identity=24.3852459016393, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67469; Mature: 67337

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCEEECCCCCEEECCCCC
AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDD
CCCEEECCHHHCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
TLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEA
HHHHHHHHCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELGLDAAGIEAKIKAWLA
HHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCEEECCCCCEEECCCCC
AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDD
CCCEEECCHHHCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
TLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEA
HHHHHHHHCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELGLDAAGIEAKIKAWLA
HHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA