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The map label for this gene is kefC [H]

Identifier: 16763476

GI number: 16763476

Start: 98778

End: 100640

Strand: Direct

Name: kefC [H]

Synonym: STM0086

Alternate gene names: 16763476

Gene position: 98778-100640 (Clockwise)

Preceding gene: 16763475

Following gene: 16763477

Centisome position: 2.03

GC content: 58.19

Gene sequence:

>1863_bases
ATGGATAGCCATACTCTACTGCAGGCGCTGATCTATCTTGGTTCGGCGGCGTTGATTGTGCCGATTGCGGTACGTTTGGG
CTTAGGATCGGTGCTGGGGTATCTGATTGCGGGTTGCATTATCGGTCCCTGGGGGCTACGGCTGGTGACGGACGCCGAAT
CTATTCTGCATTTTGCGGAAATCGGCGTCGTGCTGATGTTGTTTGTTATTGGACTTGAGCTGGACCCGCAACGGTTATGG
AAGCTGCGCGCCTCGGTATTTGGCGGCGGCGCGTTACAGATGGGGGTCTGCGGCGGACTGATTGGTCTGTTCTGTATGTT
TCTTGGCCTGCGTTGGCAGGTGGCGGAACTGATTGGCATGACGCTGGCGCTTTCGTCCACGGCTATCGCCATGCAGGCAA
TGAATGAGCGTAACCTGACCGTTTCGCAAGTAGGGCGTAGCGCATTTGCAGTGCTCTTGTTCCAGGATATCGCGGCGATC
CCGCTGGTGGCGATGATTCCGCTGCTGGCCGCCAGCGGCGCATCCACCACGCTTGGCGCGTTTGCGCTATCGGCGTTGAA
AGTCGCAGGCGCGTTGGCGCTGGTGGTGTTGCTGGGACGCTACGTTACGCGCCCGGCGCTGCGCTTTGTCGCGCGTTCTG
GTTTGCGGGAAGTGTTCAGCGCCGTGGCGCTATTTCTGGTGTTTGGTTTCGGCCTGTTGCTGGAAGAGGTTGGGCTGTCA
ATGGCGATGGGCGCGTTCCTGGCGGGCGTTCTGCTGGCGAGTTCGGAATACCGTCATGCGCTGGAAAGCGATATTGAACC
CTTTAAGGGGTTGCTGCTGGGGCTGTTCTTTATTGGCGTCGGCATGTCGATTGATTTCGGCACGCTGGTGGAGAATCCGC
TGCGCATTCTGCTGTTGTTGGCCGGTTTTCTGGCAATCAAAATCGTCATGCTGTGGCTGGTCGCGAGGCCGCTGGGCGTA
CCGGCAAAACAGCGTCGCTGGTTTGCCGTCTTATTAGGCCAGGGAAGTGAGTTTGCGTTTGTGGTTTTTGGCGCGGCGCA
AATGGCGGATGTACTTGAGCCGGAATGGGCAAAAGCGCTGACGCTGGCGGTCGCGCTGTCGATGGCGGCTACGCCGATTT
TTCTGGTGCTGCTGACGCGCATGGAGAAGACCGCGACGGGTGAAGCGCGCGAGGCGGATGAAATCGACGAAGAGCAACCG
CGGGTTATTGTGGCCGGGTTTGGACGATTTGGTCAGATAGCCGGGCGTTTGCTGCTGTCGAGCGGGGTGAAGATGGTGGT
GCTCGATCACGACCCCGATCATATCGAAACGCTGCGTAAATTCGGCATGAAGGTTTTTTATGGCGACGCGACGCGTATGG
ATTTACTGGAATCTGCCGGAGCGGCGAAGGCGGAGGTATTGATTAACGCCATTGACGATCCGCAAACCAATTTGCAACTG
AGTGAACTGGTGAAGTCGCATTTCCCGCATCTGCAGATTATCGCCCGCGCCCGTGATGTCGATCATTACATTCGCCTGCG
CCAGGCTGGTGTGGCGATGCCCGAACGTGAAACCTTCGAAGGCGCGCTCAAAAGCGGGCGACAGGCGCTGGAGGCGCTGG
GGCTGGGGCGTTATGAAGCCCGCGAGCGCGCGGATCTGTTCCGTCATTTTAATACCCGGATGGTGGAAGAGATGGCGAAA
GGGGAAAACGATCCGTTATCTCGCGCCGCCGCCTATAAACGTACCAGCGCGATGTTGAGCGAAATTATTACCGAGGACCG
GGAGCATCTGTCGTTGATTCAGCGCCACGGCTGGCAGGGAACGGCTGAGGGCAAACATTCCGGGGAGGTCGCCGATGAAC
CCGAGGTCAAACCGTCAATCTAA

Upstream 100 bases:

>100_bases
CCGTTTGCCATGCACTGCACGTTCATTTGCGATGACGACACCTTACAGGCGCAGGCGCGTCAGTATAAACAGCGTTTACT
GGCATGGCAGGAGGTGAATC

Downstream 100 bases:

>100_bases
AGTAAAAAATGTGATGTTCTGCAAACTTTACTGCTAATTGGCTGTTTTTGAACTACTGTAATGCTGGCGCTCCACATCAA
ATGAGTGGCGTCGCCAGCAG

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 620; Mature: 620

Protein sequence:

>620_residues
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMGVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAI
PLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLAIKIVMLWLVARPLGV
PAKQRRWFAVLLGQGSEFAFVVFGAAQMADVLEPEWAKALTLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEARERADLFRHFNTRMVEEMAK
GENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQGTAEGKHSGEVADEPEVKPSI

Sequences:

>Translated_620_residues
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMGVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAI
PLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLAIKIVMLWLVARPLGV
PAKQRRWFAVLLGQGSEFAFVVFGAAQMADVLEPEWAKALTLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEARERADLFRHFNTRMVEEMAK
GENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQGTAEGKHSGEVADEPEVKPSI
>Mature_620_residues
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLW
KLRASVFGGGALQMGVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAI
PLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLAIKIVMLWLVARPLGV
PAKQRRWFAVLLGQGSEFAFVVFGAAQMADVLEPEWAKALTLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQP
RVIVAGFGRFGQIAGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEARERADLFRHFNTRMVEEMAK
GENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQGTAEGKHSGEVADEPEVKPSI

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=390, Percent_Identity=25.1282051282051, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1786232, Length=619, Percent_Identity=90.3069466882068, Blast_Score=1126, Evalue=0.0,
Organism=Escherichia coli, GI1789749, Length=605, Percent_Identity=44.6280991735537, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1786685, Length=517, Percent_Identity=30.3675048355899, Blast_Score=163, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67055; Mature: 67055

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAE
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
IGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMGVCGGLIGLFCMFLGLRWQVAELIGM
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAIPLVAMIPLLAASGASTTLGA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AGFLAIKIVMLWLVARPLGVPAKQRRWFAVLLGQGSEFAFVVFGAAQMADVLEPEWAKAL
HHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEECCCCCEEEEEECHHHHHHHCCHHHHHHH
TLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQPRVIVAGFGRFGQIAGRLLLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEEECCCHHHHHHHHHHHH
SGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
CCCEEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCHH
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
RERADLFRHFNTRMVEEMAKGENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
TAEGKHSGEVADEPEVKPSI
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAE
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHH
IGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMGVCGGLIGLFCMFLGLRWQVAELIGM
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAIPLVAMIPLLAASGASTTLGA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AGFLAIKIVMLWLVARPLGVPAKQRRWFAVLLGQGSEFAFVVFGAAQMADVLEPEWAKAL
HHHHHHHHHHHHHHHHCCCCCHHHCCEEEEEECCCCCEEEEEECHHHHHHHCCHHHHHHH
TLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQPRVIVAGFGRFGQIAGRLLLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCEEEEECCCHHHHHHHHHHHH
SGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
CCCEEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCHH
SELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
RERADLFRHFNTRMVEEMAKGENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
TAEGKHSGEVADEPEVKPSI
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA