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The map label for this gene is fixC [H]

Identifier: 16763467

GI number: 16763467

Start: 90461

End: 91747

Strand: Direct

Name: fixC [H]

Synonym: STM0077

Alternate gene names: 16763467

Gene position: 90461-91747 (Clockwise)

Preceding gene: 16763466

Following gene: 16763468

Centisome position: 1.86

GC content: 55.48

Gene sequence:

>1287_bases
ATGTCCGAAGATATCTTTGATGCCATCATCGTGGGTGCAGGTCTGGCCGGTTCGGTTGCGGCGCTGGTGCTTGCTCGCGA
AGGTGCACAGGTGCTGGTTATCGAGCGCGGCAATTCTGCTGGCGCGAAGAATGTCACCGGTGGGCGCTTGTATGCACATA
GCCTGGAACGCATCATTCCCGGCTTTGCGGATCAGGCCCCCATTGAACGCATGATCACCCACGAAAAACTCGCCTTTATG
ACCGACAACGGGGCGATGACTATCGACTACTGCAATGGTGAAGATGCTTCAGCGTCGCAGGTTTCCTATTCCGTCTTACG
CAGTAAATTTGACGCCTGGCTGATGGAGCAGGCCGAAGAGGCGGGGGCGCAACTGATCACCGGTATTCGCGTGGATAACG
TTGTTCAGCGTGATGGCAAAGTCGTGGGCGTGGAAGCCGATGGCGATATTCTGGAAGCCAAAGTCGTGATCCTCGCTGAC
GGGGTGAATTCTCTGCTGGCTGAAAAGCTGGGCATGACCAAGCGTGTTGAGGCATCGCATGTTGCTGTCGGCGTGAAGGA
ACTGATCGAATTGCCGAAGTTGGTCATTGAAGATCGTTTCCAGTTACAGGGCAACGAAGGTGCCGCCTGTCTGTTTGCCG
GAGCGCCGACCGATGGTCTGATGGGCGGTGGCTTCCTGTATACGAATGAAACAACCCTTTCCCTGGGGCTGGTCTGCGGT
CTTCATCATCTGAAAGACGCGAAAAAATCGGTCCCGCAAATGCTGGAAGATTTCAAACAGCATCCGGCAGTTGCGCCGCT
GATCGCCGGTGGCAAGCTGGTGGAATATGCCGCGCACGTTGTACCCGAGGCGGGAATGAATATGCAGCCTGAACTGGTGG
GCGATGGCGTACTGATTGCCGGGGATGCTGCCGGCATGTGTATGAACCTCGGCTTTACCATCCGGGGTATGGATCTCGCC
ATATCCGCAGGCGAAGCGGCGGCGAAGACGGTGCTTTCGGCGATGAAGCGCGACGATTTTAGCAAGCAGTCGCTGGGTGA
ATACCGTCAGCATCTGGACGAAGGTCCGATGCGCGATATGCGCATGTATCAGAAACTACCGGCTTTTCTTGATAATCCCC
GCATGTTTACCGCTTATCCCGAAATGGCGGTCAATATCGCGCGCGACCTGTTCACCGTGGATGGCTCCGCTCCGGTGCCC
ATGCGTAAAAAAATCCTGCGCCATGCGAAGAAAGTGGGCTTCATTAATCTGATGAAAGATGGCCTGAAAGGAGTGACCGT
ATTATGA

Upstream 100 bases:

>100_bases
GGCGATGCGCTGAAGATCCTGCCTGCGCTGACGGCTGCCTTAGCGCGATAAACCATTTCGGGCAGGATGCGAAGGTATCC
TGCCGCTGACAGGAGTACGT

Downstream 100 bases:

>100_bases
CATCTCCCGTTAATGTGGACGTCAAACTGGGCGTCAATAAGTTCAATGTGGATGAAGACAGCCCGCACATCATTCTCAAA
ACCGATCCTGATAAACAGGC

Product: oxidoreductase FixC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIPGFADQAPIERMITHEKLAFM
TDNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILAD
GVNSLLAEKLGMTKRVEASHVAVGVKELIELPKLVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCG
LHHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIAGDAAGMCMNLGFTIRGMDLA
ISAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDMRMYQKLPAFLDNPRMFTAYPEMAVNIARDLFTVDGSAPVP
MRKKILRHAKKVGFINLMKDGLKGVTVL

Sequences:

>Translated_428_residues
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIPGFADQAPIERMITHEKLAFM
TDNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILAD
GVNSLLAEKLGMTKRVEASHVAVGVKELIELPKLVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCG
LHHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIAGDAAGMCMNLGFTIRGMDLA
ISAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDMRMYQKLPAFLDNPRMFTAYPEMAVNIARDLFTVDGSAPVP
MRKKILRHAKKVGFINLMKDGLKGVTVL
>Mature_427_residues
SEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIPGFADQAPIERMITHEKLAFMT
DNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILADG
VNSLLAEKLGMTKRVEASHVAVGVKELIELPKLVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCGL
HHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIAGDAAGMCMNLGFTIRGMDLAI
SAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDMRMYQKLPAFLDNPRMFTAYPEMAVNIARDLFTVDGSAPVPM
RKKILRHAKKVGFINLMKDGLKGVTVL

Specific function: Could be part of an electron transfer system required for anaerobic carnitine reduction [H]

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF-QO/fixC family [H]

Homologues:

Organism=Homo sapiens, GI119703746, Length=382, Percent_Identity=26.9633507853403, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786227, Length=428, Percent_Identity=88.5514018691589, Blast_Score=767, Evalue=0.0,
Organism=Escherichia coli, GI1787991, Length=429, Percent_Identity=60.6060606060606, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI87082155, Length=431, Percent_Identity=41.2993039443155, Blast_Score=323, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI25144720, Length=444, Percent_Identity=25.9009009009009, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324932, Length=376, Percent_Identity=26.3297872340426, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24652256, Length=365, Percent_Identity=29.041095890411, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: NA

Molecular weight: Translated: 45771; Mature: 45639

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIP
CCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFADQAPIERMITHEKLAFMTDNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEE
CCCCCCHHHHHHHHHHEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILADGVNSLLAEKLGMTKRVEASH
HHHHHHHCCCHHHHHHCCCEEEEEECCCCEEEEEEEEEECCHHHHHHHHHCCCCCCCHHH
VAVGVKELIELPKLVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCG
HHHHHHHHHHHHHHHHCCHHEECCCCCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHH
LHHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
GDAAGMCMNLGFTIRGMDLAISAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDM
CCCCCHHEECCEEEECCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
RMYQKLPAFLDNPRMFTAYPEMAVNIARDLFTVDGSAPVPMRKKILRHAKKVGFINLMKD
HHHHHHHHHHCCCEEEEECHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHHHHHH
GLKGVTVL
CCCCCCCC
>Mature Secondary Structure 
SEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLERIIP
CHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFADQAPIERMITHEKLAFMTDNGAMTIDYCNGEDASASQVSYSVLRSKFDAWLMEQAEE
CCCCCCHHHHHHHHHHEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGAQLITGIRVDNVVQRDGKVVGVEADGDILEAKVVILADGVNSLLAEKLGMTKRVEASH
HHHHHHHCCCHHHHHHCCCEEEEEECCCCEEEEEEEEEECCHHHHHHHHHCCCCCCCHHH
VAVGVKELIELPKLVIEDRFQLQGNEGAACLFAGAPTDGLMGGGFLYTNETTLSLGLVCG
HHHHHHHHHHHHHHHHCCHHEECCCCCCEEEEECCCCCCCCCCCEEEECCCHHHHHHHHH
LHHLKDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYAAHVVPEAGMNMQPELVGDGVLIA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
GDAAGMCMNLGFTIRGMDLAISAGEAAAKTVLSAMKRDDFSKQSLGEYRQHLDEGPMRDM
CCCCCHHEECCEEEECCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
RMYQKLPAFLDNPRMFTAYPEMAVNIARDLFTVDGSAPVPMRKKILRHAKKVGFINLMKD
HHHHHHHHHHCCCEEEEECHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHHHHHH
GLKGVTVL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a quinone or similar compound as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]